1,001 research outputs found
Inferential NMR/X-ray-based structure determination of a dibenzo[a,d]cycloheptenone inhibitor-p38a MAP kinase complex in solution.
Complex problem: The crystal structure of p38α mitogen-activated protein kinase in complex with a dibenzo[a,d]cycloheptenone inhibitor was found to be incompatible with NMR data of the same complex in solution. By using inferential structure determination (ISD) with restraints from X-ray crystallography and NMR spectra, a structure that is compatible with both data sets and very close to the X-ray crystal structure was generated (see picture)
The Geometry and Moduli of K3 Surfaces
These notes will give an introduction to the theory of K3 surfaces. We begin
with some general results on K3 surfaces, including the construction of their
moduli space and some of its properties. We then move on to focus on the theory
of polarized K3 surfaces, studying their moduli, degenerations and the
compactification problem. This theory is then further enhanced to a discussion
of lattice polarized K3 surfaces, which provide a rich source of explicit
examples, including a large class of lattice polarizations coming from elliptic
fibrations. Finally, we conclude by discussing the ample and Kahler cones of K3
surfaces, and give some of their applications.Comment: 34 pages, 2 figures. (R. Laza, M. Schutt and N. Yui, eds.
A simply connected surface of general type with p_g=0 and K^2=2
In this paper we construct a simply connected, minimal, complex surface of
general type with p_g=0 and K^2=2 using a rational blow-down surgery and
Q-Gorenstein smoothing theory.Comment: 19 pages, 6 figures. To appear in Inventiones Mathematica
K\"{a}hler-Einstein metrics on strictly pseudoconvex domains
The metrics of S. Y. Cheng and S.-T. Yau are considered on a strictly
pseudoconvex domains in a complex manifold. Such a manifold carries a complete
K\"{a}hler-Einstein metric if and only if its canonical bundle is positive. We
consider the restricted case in which the CR structure on is
normal. In this case M must be a domain in a resolution of the Sasaki cone over
. We give a condition on a normal CR manifold which it cannot
satisfy if it is a CR infinity of a K\"{a}hler-Einstein manifold. We are able
to mostly determine those normal CR 3-manifolds which can be CR infinities.
Many examples are given of K\"{a}hler-Einstein strictly pseudoconvex manifolds
on bundles and resolutions.Comment: 30 pages, 1 figure, couple corrections, improved a couple example
Continuous- and dispersed-phase structure of dense nonevaporating pressure-atomized sprays
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77144/1/AIAA-23475-448.pd
Temporal and structural genetic variation in reindeer (Rangifer tarandus) associated with the pastoral transition in Northwestern Siberia
Funding Information NordForsk. Grant Number: 76915 ERC Advanced Grant. Grant Numbers: 295458, ESRC ES/, M011054/1 JPI HUMANOR ERC Starting GrantPeer reviewedPublisher PD
Classification of singular Q-homology planes. I. Structure and singularities
A Q-homology plane is a normal complex algebraic surface having trivial
rational homology. We obtain a structure theorem for Q-homology planes with
smooth locus of non-general type. We show that if a Q-homology plane contains a
non-quotient singularity then it is a quotient of an affine cone over a
projective curve by an action of a finite group respecting the set of lines
through the vertex. In particular, it is contractible, has negative Kodaira
dimension and only one singular point. We describe minimal normal completions
of such planes.Comment: improved results from Ph.D. thesis (University of Warsaw, 2009), 25
pages, to appear in Israel J. Mat
Advanced EFL learners' beliefs about language learning and teaching: a comparison between grammar, pronunciation, and vocabulary
This paper reports on the results of a study exploring learnersâ beliefs on the learning and teaching of English grammar, pronunciation and vocabulary at tertiary level. While the importance of learnersâ beliefs on the acquisition process is generally recognized, few studies have focussed on and compared learnersâ views on different components of the language system. A questionnaire containing semantic scale and Likert scale items probing learnersâ views on grammar, pronunciation and vocabulary was designed and completed by 117 native speakers of Dutch in Flanders, who were studying English at university. The analysis of the responses revealed that (i) vocabulary was considered to be different from grammar and pronunciation, both in the extent to which an incorrect use could lead to communication breakdown and with respect to the learnersâ language learning strategies, (ii) learners believed in the feasibility of achieving a native-like proficiency in all three components, and (iii) in-class grammar, pronunciation and vocabulary exercises were considered to be useful, even at tertiary level. The results are discussed in light of pedagogical approaches to language teaching
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