Feasibility of an Incoherent-scatter Radar Aboard the Space Shuttle

The results of a preliminary study to investigate the feasibility of conducting an incoherent scatter radar experiment on board the space shuttle are presented. The results indicate that such an experiment is technically feasible. The more difficult questions to answer are whether the system can be made flexible enough to justify the problems and costs involved. The design parameters and the tradeoffs that are available in the consideration of these questions are evaluated. Some of the more serious limitations pertain to: (1) the presence of ground clutter and F region auroral clutter; (2) available average power; (3) weight and volume associated with required antenna size, transmitter, and energy storage devices; and (4) antenna breakdown associated with high power transmitter problems

Derivation of viscous Burgers equations from weakly asymmetric exclusion processes

We consider weakly asymmetric exclusion processes whose initial density profile is a small perturbation of a constant. We show that in the diffusive time-scale, in all dimensions, the density defect evolves as the solution of a viscous Burgers equation

Double-sided coaxial circuit QED with out-of-plane wiring

Superconducting circuits are well established as a strong candidate platform for the development of quantum computing. In order to advance to a practically useful level, architectures are needed which combine arrays of many qubits with selective qubit control and readout, without compromising on coherence. Here we present a coaxial circuit QED architecture in which qubit and resonator are fabricated on opposing sides of a single chip, and control and readout wiring are provided by coaxial wiring running perpendicular to the chip plane. We present characterisation measurements of a fabricated device in good agreement with simulated parameters and demonstrating energy relaxation and dephasing times of $T_1 = 4.1\,\mu$s and $T_2 = 5.7\,\mu$s respectively. The architecture allows for scaling to large arrays of selectively controlled and measured qubits with the advantage of all wiring being out of the plane.Comment: 4 pages, 3 figures, 1 tabl

Magnetotransport properties of lithographically defined lateral Co/Ni80Fe20 wires

In this article we have investigated the magnetization reversal process of laterally defined coupled magnetic structures consisting of micron-sized sputtered Co and Ni80Fe20 wires lying side by side at temperatures ranging from 3 to 300 K. We have used a microfabrication technique to create an array of planar, laterally coupled magnetic wires made of two ferromagnetic materials. We observed two distinct peaks in the magnetoresistance (MR) curves corresponding to the magnetization reversals of Co and Ni80Fe20 wires. Below a critical temperature of 20 K we observed an asymmetric shift in the Ni80Fe20 peak position for both forward and reverse field sweeps due to the exchange coupling between the ferromagnetic (Ni80Fe20) and antiferromagnetic (Co–oxide at the interface of Co and Ni80Fe20 formed during fabrication) parts. The Co peaks gradually disappeared as the temperature was reduced. At low temperature we also observed that the Ni80Fe20 peaks in the MR loops are considerably shifted to larger fields corresponding to the increase in coercivity

MoRFPred-plus: Computational Identification of MoRFs in Protein Sequence using physicochemical properties and HMM profiles

Intrinsically Disordered Proteins (IDPs) lack stable tertiary structure and they actively participate in performing various biological functions. These IDPs expose short binding regions called Molecular Recognition Features (MoRFs) that permit interaction with structured protein regions. Upon interaction they undergo a disorder-to-order transition as a result of which their functionality arises. Predicting these MoRFs in disordered protein sequences is a challenging task. In this study, we present MoRFpred-plus, an improved predictor over our previous proposed predictor to identify MoRFs in disordered protein sequences. Two separate independent propensity scores are computed via incorporating physicochemical properties and HMM profiles, these scores are combined to predict final MoRF propensity score for a given residue. The first score reflects the characteristics of a query residue to be part of MoRF region based on the composition and similarity of assumed MoRF and flank regions. The second score reflects the characteristics of a query residue to be part of MoRF region based on the properties of flanks associated around the given residue in the query protein sequence. The propensity scores are processed and common averaging is applied to generate the final prediction score of MoRFpred-plus. Performance of the proposed predictor is compared with available MoRF predictors, MoRFchibi, MoRFpred, and ANCHOR. Using previously collected training and test sets used to evaluate the mentioned predictors, the proposed predictor outperforms these predictors and generates lower false positive rate. In addition, MoRFpred-plus is a downloadable predictor, which makes it useful as it can be used as input to other computational tools

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study.

Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans. Intestinal microbes are important contributors to variability; however, such gut microbe-drug interactions and the clinical significance of these interactions are still being elucidated. Traditional PKs can be complemented by untargeted mass spectrometry coupled with molecular networking to study the intricacies of drug metabolism. To show the utility of molecular networking on metabolism we investigated the impact of a 7-day course of cefprozil on cytochrome P450 (CYP) activity using a modified Cooperstown cocktail and assessed plasma, urine, and fecal data by targeted and untargeted metabolomics and molecular networking in healthy volunteers. This prospective study revealed that cefprozil decreased the activities of CYP1A2, CYP2C19, and CYP3A, decreased alpha diversity and increased interindividual microbiome variability. We further demonstrate a relationship between the loss of microbiome alpha diversity caused by cefprozil and increased drug and metabolite formation in fecal samples. Untargeted metabolomics/molecular networking revealed several omeprazole metabolites that we hypothesize may be metabolized by both CYP2C19 and bacteria from the gut microbiome. Our observations are consistent with the hypothesis that factors that perturb the gut microbiome, such as antibiotics, alter drug metabolism and ultimately drug efficacy and toxicity but that these effects are most strongly revealed on a per individual basis