Nuclear matrix protein 2 antibody-positive adult dermatomyositis: a case report and review of the literature

Dermatomyositis is a clinically heterogenous inflammatory myopathy with unique cutaneous features. Myositis-specific antibodies can aid in diagnosis and anticipation of patient prognosis. Herein, we report a 22-year-old man who presented with multifocal erythematous plaques with violaceous papules on his bilateral elbows, neck, and face. He was diagnosed with biopsy-proven dermatomyositis and determined to be seropositive for nuclear matrix protein 2 antibody (NXP-2). He was treated with systemic corticosteroids, then intravenous methylprednisolone and azathioprine, and ultimately achieved greatest treatment response with intravenous immune globulin therapy

Comprehension Strategy Lesson Plans for Third Grade Teachers Incorporating Informational Science Trade Books

The purpose of this project is to create a set of lesson plans for teachers useful in teaching comprehension strategies to monolingual third grade students. Research on comprehension strategies and the effects they have on children\u27s reading comprehension was explored. Effective comprehension strategies were defined. Lesson plans were created to aid educators as they teach comprehension of informational material to third grade students

Bioeconomics of the Philippine small pelagics fishery

Time series analysis of catch and effort data in the Philippines small pelagics fishery resulted in a level of biological and economic overexploitation. Open-access equilibrium has been reached at 410,000 hp representing a catch level of 465,000 tonnes. Present levels of effort would have to be reduced by 40% to attain maximum economic yield. An analysis of producer surplus showed that municipal aand commercial fishers were sustaining pure losses amounting to P9.4 billion indicating misallocation of labor and capital in an already overexploited fishery. Solutions to fisheries management problems are shown to emanate not just from the fishery, but more importantly, from the broader macroeconomic environment.Pelagic fisheries, Bioeconomics, Fishery economics, Fishery management, Philippines,

Multiple Sources toward the High-mass Young Star S140 IRS1

S140 IRS1 is a remarkable source where the radio source at the center of the main bipolar molecular outflow in the region is elongated perpendicular to the axis of the outflow, an orientation opposite to that expected if the radio source is a thermal jet exciting the outflow. We present results of 1.3 cm continuum and H2O maser emission observations made with the VLA in its A configuration toward this region. In addition, we also present results of continuum observations at 7 mm and re-analyse observations at 2, 3.5 and 6 cm (previously published). IRS 1A is detected at all wavelengths, showing an elongated structure. Three water maser spots are detected along the major axis of the radio source IRS 1A. We have also detected a new continuum source at 3.5 cm (IRS 1C) located ~0.6'' northeast of IRS 1A. The presence of these two YSOs (IRS 1A and 1C) could explain the existence of the two bipolar molecular outflows observed in the region. In addition, we have also detected three continuum clumps (IRS 1B, 1D and 1E) located along the major axis of IRS 1A. We discuss two possible models to explain the nature of IRS 1A: a thermal jet and an equatorial wind.Comment: 17 pages, 4 figures, to be published in A

Microbiome profile associated with malignant pleural effusion.

INTRODUCTION:There is ongoing research into the development of novel molecular markers that may complement fluid cytology malignant pleural effusion (MPE) diagnosis. In this exploratory pilot study, we hypothesized that there are distinct differences in the pleural fluid microbiome profile of malignant and non-malignant pleural diseases. METHOD:From a prospectively enrolled pleural fluid biorepository, samples of MPE were included. Non-MPE effusion were included as comparators. 16S rRNA gene V4 region amplicon sequencing was performed. Exact Sequence Variants (ESVs) were used for diversity analyses. The Shannon and Richness indices of alpha diversity and UniFrac beta diversity measures were tested for significance using permutational multivariate analysis of variance. Analyses of Composition of Microbiome was used to identify differentially abundant bacterial ESVs between the groups controlled for multiple hypothesis testing. RESULTS:38 patients with MPE and 9 with non-MPE were included. A subgroup of patients with metastatic adenocarcinoma histology were identified among MPE group (adenocarcinoma of lung origin (LA-MPE) = 11, breast origin (BA-MPE) = 11). MPE presented with significantly greater alpha diversity compared to non-MPE group. Within the MPE group, BA-MPE was more diverse compared to LA-MPE group. In multivariable analysis, ESVs belonging to family S24-7 and genera Allobaculum, Stenotrophomonas, and Epulopiscium were significantly enriched in the malignant group compared to the non-malignant group. CONCLUSION:Our results are the first to demonstrate a microbiome signature according to MPE and non-MPE. The role of microbiome in pleural effusion pathogenesis needs further exploration

Formation of S0 galaxies through mergers. Evolution in the Tully-Fisher relation since z∼1z\sim1

(Abridged version) We explore whether a scenario that combines an origin by mergers at $z\sim$1.8-1.5 with a subsequent passive evolution of the resulting S0 remnants since $z \sim$0.8-1 is compatible with observational data of S0s in the Tully-Fisher relation (TFR). We studied a set of major and minor merger experiments from the GalMer database that generate massive S0 remnants. We analysed the location of these remnants in the photometric and stellar TFRs assuming that they correspond to $z\sim0.8$ galaxies. We then estimated their evolution in these planes over the last 7 Gyr. The results were compared with data of real S0s and spirals at different redshifts. We also tested how the use of Vcirc or Vrot,max affects the results. We found that just after $\sim$1-2 Gyr of coalescence, major mergers generate S0 remnants that are outliers of the local photometric and stellar TFRs at $z\sim0.8$. After $\sim$4-7 Gyr of passive evolution in isolation, the S0 remnants move towards the local TFR, although the initial scatter among them persists. This scatter is sensitive to the indicator used for the rotation velocity: Vcirc values yield a lower scatter than when Vrot,max values are considered instead. In the planes involving Vrot,max, a clear segregation of the S0 remnants in terms of the spin-orbit coupling of the model is observed, in which the remnants of retrograde encounters overlap with local S0s hosting counter-rotating discs. The location of the S0 remnants at $z\sim 0$ agrees well with the observed distribution of local S0 galaxies in the $\sigma_0$-$M_K$, Vcirc-$\sigma_0$ and Vrot,max-$\sigma_0$ planes. Thus, massive S0 galaxies may have been formed through major mergers that occurred at high redshift and have later evolved towards the local TFR through passive evolution in relative isolation, a mechanism that would also contribute to the scatter observed in this relation.Comment: 19 pages, 15 figures. Accepted for publication in A&

Métodos de un paso para ecuaciones diferenciales ordinarias: recursos didácticos

El objeto de este trabajo es mostrar la utilidad, desde el punto de vista didáctico, de las hojas de cálculo Excel en la aplicación de diferentes métodos numéricos a la resolución de problemas de valor inicial de ecuaciones diferenciales ordinarias. Con el fin de verificar la convergencia de cada uno de los métodos aplicados se consideran diferentes longitudes de paso h, comenzando por un cierto valor y dividiendo sucesivamente h entre dos hasta conseguir una aproximación adecuada. Aplicando los distintos métodos numéricos a un mismo problema de valor inicial es posible comparar la velocidad de convergencia de los diferentes métodos aplicados. Analizando los resultados obtenidos a través de las hojas de Excel es posible conseguir directamente cotas del error cometido al aplicar cada uno de los diferentes métodos, sin un conocimiento previo de la solución exacta del problema