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Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108083/1/hep26952.pd

Introduction to HOBIT, a b-Jet Identification Tagger at the CDF Experiment Optimized for Light Higgs Boson Searches

We present the development and validation of the Higgs Optimized b Identification Tagger (HOBIT), a multivariate b-jet identification algorithm optimized for Higgs boson searches at the CDF experiment at the Fermilab Tevatron. At collider experiments, b taggers allow one to distinguish particle jets containing B hadrons from other jets; these algorithms have been used for many years with great success at CDF. HOBIT has been designed specifically for use in searches for light Higgs bosons decaying via H ! b\bar{b}. This fact combined with the extent to which HOBIT synthesizes and extends the best ideas of previous taggers makes HOBIT unique among CDF b-tagging algorithms. Employing feed-forward neural network architectures, HOBIT provides an output value ranging from approximately -1 ("light-jet like") to 1 ("b-jet like"); this continuous output value has been tuned to provide maximum sensitivity in light Higgs boson search analyses. When tuned to the equivalent light jet rejection rate, HOBIT tags 54% of b jets in simulated 120 GeV/c2 Higgs boson events compared to 39% for SecVtx, the most commonly used b tagger at CDF. We present features of the tagger as well as its characterization in the form of b-jet finding efficiencies and false (light-jet) tag rates.Comment: 40 pages, 16 figue

Chaotic memristor

We suggest and experimentally demonstrate a chaotic memory resistor (memristor). The core of our approach is to use a resistive system whose equations of motion for its internal state variables are similar to those describing a particle in a multi-well potential. Using a memristor emulator, the chaotic memristor is realized and its chaotic properties are measured. A Poincar\'{e} plot showing chaos is presented for a simple nonautonomous circuit involving only a voltage source directly connected in series to a memristor and a standard resistor. We also explore theoretically some details of this system, plotting the attractor and calculating Lyapunov exponents. The multi-well potential used resembles that of many nanoscale memristive devices, suggesting the possibility of chaotic dynamics in other existing memristive systems.Comment: Applied Physics A (in press

Coordinated induction of cell survival signaling in the inflamed microenvironment of the prostate

PURPOSE: Both prostate cancer and benign prostatic hyperplasia are associated with inflammatory microenvironments. Inflammation is damaging to tissues, but it is unclear how the inflammatory microenvironment protects specialized epithelial cells that function to proliferate and repair the tissue. The objective of this study is to characterize the cell death and cell survival response of the prostatic epithelium in response to inflammation. METHODS: We assessed induction of cell death (TNF, TRAIL, TWEAK, FasL) and cell survival factors (IGFs, hedgehogs, IL-6, FGFs, and TGFs) in inflamed and control mouse prostates by ELISA. Cell death mechanisms were determined by immunoblotting and immunofluorescence for cleavage of caspases and TUNEL. Survival pathway activation was assessed by immunoblotting and immunofluorescence for Mcl-1, Bcl-2, Bcl-XL, and survivin. Autophagy was determined by immunoblotting and immunofluorescence for free and membrane associated light chain 3 (LC-3). RESULTS: Cleavage of all four caspases was significantly increased during the first 2 days of inflammation, and survival protein expression was substantially increased subsequently, maximizing at 3 days. By 5 days of inflammation, 50% of prostatic epithelial cells expressed survivin. Autophagy was also evident during the recovery phase (3 days). Finally, immunofluorescent staining of human specimens indicates strong activation of survival proteins juxtaposed to inflammation in inflamed prostate specimens. CONCLUSIONS: The prostate responds to deleterious inflammation with induction of cell survival mechanisms, most notably survivin and autophagy, demonstrating a coordinated induction of survival factors that protects and expands a specialized set of prostatic epithelial cells as part of the repair and recovery process during inflammation

TSH-CHECK-1 test: diagnostic accuracy and potential application to initiating treatment for hypothyroidism in patients on anti-tuberculosis drugs.

Thyroid-stimulating hormone (TSH) promotes expression of thyroid hormones which are essential for metabolism, growth, and development. Second-line drugs to treat tuberculosis (TB) can cause hypothyroidism by suppressing thyroid hormone synthesis. Therefore, TSH levels are routinely measured in TB patients receiving second-line drugs, and thyroxin treatment is initiated where indicated. However, standard TSH tests are technically demanding for many low-resource settings where TB is prevalent; a simple and inexpensive test is urgently needed

Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis

BACKGROUND: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial peritonitis, we investigated whether serum ProCT levels are elevated and correlate with mortality and hypocalcemia. RESULTS: Incremental increases in doses of bacteria resulted in proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250, 380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml). Gel filtration studies revealed that ProCT was the predominant (> 90%) molecular form of serum iCT secreted. In the metabolic experiments, total iCT peaked at 12 h concurrent with the maximal decrease in serum calcium. CONCLUSIONS: In this animal model, hyper-procalcitoninemia was an early systemic marker of sepsis which correlated closely with mortality and had an inverse correlation with serum calcium levels

In Situ Resistance Measurements of Strained Carbon Nanotubes

We investigate the response of multi-walled carbon nanotubes to mechanical strain applied with an Atomic Force Microscope (AFM) probe. We find that in some samples, changes in the contact resistance dominate the measured resistance change. In others, strain large enough to fracture the tube can be applied without a significant change in the contact resistance. In this case we observe that enough force is applied to break the tube without any change in resistance until the tube fails. We have also manipulated the ends of the broken tube back in contact with each other, re-establishing a finite resistance. We observe that in this broken configuration the resistance of the sample is tunable to values 15-350 kW greater than prior to breaking.Comment: Submitted to Applied Physics Letter

Optical and Infrared Photometry of the Unusual Type Ia Supernova 2000cx

We present optical and infrared photometry of the unusual Type Ia supernova 2000cx. With the data of Li et al. (2001) and Jha (2002), this comprises the largest dataset ever assembled for a Type Ia SN, more than 600 points in UBVRIJHK. We confirm the finding of Li et al. regarding the unusually blue B-V colors as SN 2000cx entered the nebular phase. Its I-band secondary hump was extremely weak given its B-band decline rate. The V minus near infrared colors likewise do not match loci based on other slowly declining Type Ia SNe, though V-K is the least ``abnormal''. In several ways SN 2000cx resembles other slow decliners, given its B-band decline rate (Delta m_15(B) = 0.93), the appearance of Fe III lines and weakness of Si II in its pre-maximum spectrum, the V-K colors and post-maximum V-H colors. If the distance modulus derived from Surface Brightness Fluctuations of the host galaxy is correct, we find that the rate of light increase prior to maximum, the characteristics of the bolometric light curve, and the implied absolute magnitude at maximum are all consistent with a sub-luminous object with Delta m_15(B) ~ 1.6-1.7 having a higher than normal kinetic energy.Comment: 46 pages, 17 figures, to be published in Publications of the Astronomical Society of the Pacifi

Digital play and the actualisation of the consumer imagination

In this article, the authors consider emerging consumer practices in digital virtual spaces. Building on constructions of consumer behavior as both a sense-making activity and a resource for the construction of daydreams, as well as anthropological readings of performance, the authors speculate that many performances during digital play are products of consumer fantasy. The authors develop an interpretation of the relationship between the real and the virtual that is better equipped to understand the movement between consumer daydreams and those practices actualized in the material and now also in digital virtual reality. The authors argue that digital virtual performances present opportunities for liminoid transformations through inversions, speculations, and playfulness acted out in aesthetic dramas. To illustrate, the authors consider specific examples of the theatrical productions available to consumers in digital spaces, highlighting the consumer imagination that feeds them, the performances they produce, and the potential for transformation in consumer-players

Ethanol and Acetaminophen Synergistically Induce Hepatic Aggregation and TCH346-Insensitive Nuclear Translocation of GAPDH

The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) signals during cellular stress via several post-translational modifications that change its folding properties, protein-protein interactions and sub-cellular localization. We examined GAPDH properties in acute mouse liver injury due to ethanol and/or acetaminophen (APAP) treatment. Synergistic robust and time-dependent nuclear accumulation and aggregation of GAPDH were observed only in combined, but not individual, ethanol/APAP treatments. The small molecule GAPDH-targeting compound TCH346 partially attenuated liver damage possibly via mitochondrial mechanisms, and independent of nuclear accumulation and aggregation of GAPDH. These findings provide a novel potential mechanism for hepatotoxicity caused by combined alcohol and acetaminophen exposure