Novel electroanalysis of hydroxyurea at glassy carbon and gold electrode surfaces

A simple and a novel electroanalysis of hydroxyurea (HU) drug at glassy carbon and gold electrode was investigated for the first time using cyclic, linear sweep and differential pulse voltammetric techniques. The oxidation of HU was irreversible and exhibited a diffusion controlled process on both electrodes. The oxidation mechanism was proposed. The dependence of the current on pH, the concentration, nature of buffer, and scan rate was investigated to optimize the experimental conditions for the determination of HU. It was found that the optimum buffer pH was 7.0, a physiological pH. In the range of 0.01 to 1.0 mM, the current measured by differential pulse voltammetry showed a linear relationship with HU concentration with limit of detection of 0.46 µM for glassy carbon electrode and 0.92 µM for gold electrode. In addition, reproducibility, precision and accuracy of the method were checked as well. The developed method was successfully applied to HU determination in pharmaceutical formulation and human biological fluids. The method finds its applications in quality control laboratories and pharmacokinetics

Fast Transition between High-soft and Low-soft States in GRS 1915+105: Evidence for a Critically Viscous Accretion Flow

We present the results of a detailed analysis of RXTE observations of class $\omega$ which show an unusual state transition between high-soft and low-soft states in the microquasar GRS 1915+105. Out of about 600 pointed RXTE observations, the source was found to exhibit such state transition only on 16 occasions. An examination of the RXTE/ASM data in conjunction with the pointed observations reveals that these events appeared as a series of quasi-regular dips in two stretches of long duration (about 20 days during each occasions) when hard X-ray and radio flux were very low. The X-ray light curve and color-color diagram of the source during these observations are found to be different from any reported so far. The duration of these dips is found to be of the order of a few tens of seconds with a repetition time of a few hundred seconds. The transition between these dips and non-dips which differ in intensity by a factor of ~ 3.5, is observed to be very fast (~ a few seconds). It is observed that the low-frequency narrow QPOs are absent in the power density spectrum (PDS) of the dip and non-dip regions of class $\omega$ and the PDS is a power law in 0.1 - 10 Hz frequency range. There is a remarkable similarity in the spectral and timing properties of the source during the dip and non-dip regions in these set of observations. These properties of the source are distinctly different from those seen in the observations of other classes. This indicates that the basic accretion disk structure during both dip and non-dip regions of class $\omega$ is similar, but differ only in intensity. To explain these observations, we invoke a model in which the viscosity is very close to critical viscosity and the shock wave is weak or absent.Comment: Replaced with correct figures, Jour. of Astrophysics and Astronomy (accepted

Feshbach resonances in the 6Li-40K Fermi-Fermi mixture: Elastic versus inelastic interactions

We present a detailed theoretical and experimental study of Feshbach resonances in the 6Li-40K mixture. Particular attention is given to the inelastic scattering properties, which have not been considered before. As an important example, we thoroughly investigate both elastic and inelastic scattering properties of a resonance that occurs near 155 G. Our theoretical predictions based on a coupled channels calculation are found in excellent agreement with the experimental results. We also present theoretical results on the molecular state that underlies the 155G resonance, in particular concerning its lifetime against spontaneous dissociation. We then present a survey of resonances in the system, fully characterizing the corresponding elastic and inelastic scattering properties. This provides the essential information to identify optimum resonances for applications relying on interaction control in this Fermi-Fermi mixture.Comment: Submitted to EPJD, EuroQUAM special issues "Cold Quantum Matter - Achievements and Prospects", v2 with updated calibration of magnetic field (+4mG correction) and updated figures 4 and

Broad band X-ray spectroscopy of A0535+262 with SUZAKU

The transient X-ray binary pulsar A0535+262 was observed with Suzaku on 2005 September 14 when the source was in the declining phase of the August-September minor outburst. The ~103 s X-ray pulse profile was strongly energy dependent, a double peaked profile at soft X-ray energy band (<3 keV) and a single peaked smooth profile at hard X-rays. The width of the primary dip is found to be increasing with energy. The broad-band energy spectrum of the pulsar is well described with a Negative and Positive power-law with EXponential (NPEX) continuum model along with a blackbody component for soft excess. A weak iron K_alpha emission line with an equivalent width ~25 eV was detected in the source spectrum. The blackbody component is found to be pulsating over the pulse phase implying the accretion column and/or the inner edge of the accretion disk may be the possible emission site of the soft excess in A0535+262. The higher value of the column density is believed to be the cause of the secondary dip at the soft X-ray energy band. The iron line equivalent width is found to be constant (within errors) over the pulse phase. However, a sinusoidal type of flux variation of iron emission line, in phase with the hard X-ray flux suggests that the inner accretion disk is the possible emission region of the iron fluorescence line.Comment: 21 pages, 6 figures. Accepted for publication in the Astrophysical Journal, 2008 January issu

Modeling of EDM electrodes for development of LPOT turbine rotor and optimization of parameters for attenuate portioned electrode by Taguchi based Grey Relational Analysis

Launch vehicle requires high thrust during lift off. Semi-cryogenic engine using liquid oxygen (LOX) as the oxidiser and kerosene (earth storable) as the fuel, produces thrust around 2000kN. LOX is pumped by Low Pressure Oxidiser Turbo pump (LPOT) to level required for cavitation free operation of the Main Oxidiser Pump (MOP). Inconel 718, the material for LPOT turbine rotor has High strength thermal resistance (HSTS), ignition resistance and property of work hardening, which refers to strengthening of metal by plastic deformation (after the machining pass). The conventional machining processes cannot be adopted to produce complex shapes with high surface finish and accuracy. The non conventional machining technique like EDM is preferred. Due to the closed tip nature of the rotor die sinking EDM is preferred over wire EDM. The LPOT turbine has two rows of rotor blades; 100 symmetric blades and 105 asymmetric blades. The modeling of the EDM electrodes is done in CAD and the trial manufacturing of the electrodes for developing symmetric blade of turbine rotor is carried out. One of the electrode is having a section with 0.4mm thickness. The EDM parameters are optimized for attenuate/thin portioned electrode using Taguchi based Grey Relation Analysis. The most significant parameter using ANOVA is found out. Confirmation test are also performed with optimum parameter combination and an improvement of machining parameter is obtained

First determination of the CPCP content of D→π+π−π+π−D \to \pi^+\pi^-\pi^+\pi^- and updated determination of the CPCP contents of D→π+π−π0D \to \pi^+\pi^-\pi^0 and D→K+K−π0D \to K^+K^-\pi^0

Quantum-correlated $\psi(3770) \to D\bar{D}$ decays collected by the CLEO-c experiment are used to perform a first measurement of $F_+^{4\pi}$, the fractional $CP$-even content of the self-conjugate decay $D \to \pi^+\pi^-\pi^+\pi^-$, obtaining a value of $0.737 \pm 0.028$. An important input to the measurement comes from the use of $D \to K^0_{\rm S}\pi^+\pi^-$ and $D \to K^0_{\rm L}\pi^+\pi^-$ decays to tag the signal mode. This same technique is applied to the channels $D \to\pi^+\pi^-\pi^0$ and $D \to K^+K^-\pi^0$, yielding $F_+^{\pi\pi\pi^0} = 1.014 \pm 0.045 \pm 0.022$ and $F_+^{KK\pi^0} = 0.734 \pm 0.106 \pm 0.054$, where the first uncertainty is statistical and the second systematic. These measurements are consistent with those of an earlier analysis, based on $CP$-eigenstate tags, and can be combined to give values of $F_+^{\pi\pi\pi^0} = 0.973 \pm 0.017$ and $F_+^{KK\pi^0} = 0.732 \pm 0.055$. The results will enable the three modes to be included in a model-independent manner in measurements of the unitarity triangle angle $\gamma$ using $B^\mp \to DK^\mp$ decays, and in time-dependent studies of $CP$ violation and mixing in the $D\bar{D}$ system.Comment: Minor revisions following journal acceptanc

Quantum dynamics of impurities in a 1D Bose gas

Using a species-selective dipole potential, we create initially localized impurities and investigate their interactions with a majority species of bosonic atoms in a one-dimensional configuration during expansion. We find an interaction-dependent amplitude reduction of the oscillation of the impurities' size with no measurable frequency shift, and study it as a function of the interaction strength. We discuss possible theoretical interpretations of the data. We compare, in particular, with a polaronic mass shift model derived following Feynman variational approach.Comment: 7 pages, 6 figure

Sparsity and cosparsity for audio declipping: a flexible non-convex approach

This work investigates the empirical performance of the sparse synthesis versus sparse analysis regularization for the ill-posed inverse problem of audio declipping. We develop a versatile non-convex heuristics which can be readily used with both data models. Based on this algorithm, we report that, in most cases, the two models perform almost similarly in terms of signal enhancement. However, the analysis version is shown to be amenable for real time audio processing, when certain analysis operators are considered. Both versions outperform state-of-the-art methods in the field, especially for the severely saturated signals

Probing the Kinetic Stabilities of Friedreich’s Ataxia Clinical Variants Using a Solid Phase GroEL Chaperonin Capture Platform

Numerous human diseases are caused by protein folding defects where the protein may become more susceptible to degradation or aggregation. Aberrant protein folding can affect the kinetic stability of the proteins even if these proteins appear to be soluble in vivo. Experimental discrimination between functional properly folded and misfolded nonfunctional conformers is not always straightforward at near physiological conditions. The differences in the kinetic behavior of two initially folded frataxin clinical variants were examined using a high affinity chaperonin kinetic trap approach at 25 °C. The kinetically stable wild type frataxin (FXN) shows no visible partitioning onto the chaperonin. In contrast, the clinical variants FXN-p.Asp122Tyr and FXN-p.Ile154Phe kinetically populate partial folded forms that tightly bind the GroEL chaperonin platform. The initially soluble FXN-p.Ile154Phe variant partitions onto GroEL more rapidly and is more kinetically liable. These differences in kinetic stability were confirmed using differential scanning fluorimetry. The kinetic and aggregation stability differences of these variants may lead to the distinct functional impairments described in Friedreich’s ataxia, the neurodegenerative disease associated to frataxin functional deficiency. This chaperonin platform approach may be useful for identifying small molecule stabilizers since stabilizing ligands to frataxin variants should lead to a concomitant decrease in chaperonin binding

Variants of fattening and flavor symmetry restoration

We study the effects of different "fat link" actions for Kogut-Susskind quarks on flavor symmetry breaking. Our method is mostly empirical - we compute the pion spectrum with different valence quark actions on common sets of sample lattices. Different actions are compared, as best we can, at equivalent physical points. We find significant reductions in flavor symmetry breaking relative to the conventional or to the "link plus staple" actions, with a reasonable cost in computer time. We also develop and test a scheme for approximate unitarization of the fat links. While our tests have concentrated on the valence quark action, our results will be useful in designing simulations with dynamical quarks.Comment: 16 pages, LaTeX, PostScript figures include