Psychopatholgy, fundamental assumptions and CD-4 T lymphocyte counts in HIV-positive patients

Objective:  Key words: Fundamental Assumptions; HIV; PsychopathologyWe investigated whether psychopathology in HIV-positive patients was associated with more negative fundamental assumptions than in healthy controls. In addition, we explored whether psychopathology and negative fundamental assumptions in HIV-positive patients were associated with lower CD4 T-lymphocyte counts. Method: Self-rating questionnaires to assess depressive symptoms, posttraumatic stress symptoms, alcohol abuse, general psychopathology and fundamental assumptions, were completed by 123 HIV-positive patients and 84 uninfected clinic attendees at three primary health care clinics in the Western Cape, South Africa. CD4 T-lymphocyte counts were obtained from chart records. Results: HIV-positive patients reported more depressive and posttraumatic symptoms than uninfected individuals. However when controlling for socio-economic status, the number of traumatic events experienced and other potential confounds, no differences remained. Fundamental assumptions (FA) were mainly positive in both HIV-positive patients and controls and no correlations were found between fundamental assumptions, psychiatric symptoms and CD4 levels. However, in infected patients FA and psychopathology were negatively associated with all participants scoring in the positive range of the FA scale. Conclusion: The positive scores on the FA scale indicate that positive assumptions are related to less psychopathology. Longitudinal studies investigating the association between the valence of fundamental assumptions and HIV morbidity are needed

The orthopantomograph as an indicator of vertical jaw relations

INTRODUCTION : Lateral cephalometry is important in the orthodontic diagnosis of jaw relationships, in treatment planning, and prediction of growth but also in the evaluation of different facial forms. Little research has evaluated the orthopantomograph for these purposes. AIM : To compare the data taken from orthopantomographs and lateral cephalograms in the investigation of vertical jaw relationships and to assess correlation between measurements. MATERIALS AND METHODS : The gonial angle, ramus height and condyle angle were measured for each patient on the two radiographs and these data compared for the three different facial growth types, dolichofacial, mesofacial and brachyfacial. RESULTS : In subjects with normal (meso-) or horizontal (brachy-) growth patterns, there were no significant differences between the mean and median values for the gonial and condyle angles, but the ramus heights showed significant differences. The data of the vertical (dolicho-) growth pattern patients recorded significant differences only between the data for the gonial angles and the ramus heights. Significant correlations were found between the gonial angles and the condyle angles for all three growth patterns, but not for ramus heights. CONCLUSION : in comparing the data from the two radiographs, the angular measurements showed high correlation and predictability whilst linear measurements showed inconsistency.https://www.sada.co.za/the-sadjam2019Orthodontic

Logic Design for Linear Regression Model Using ASIC in Engine Oil Degradation Monitoring System

A degradation analysis in automotive engine oil is concerned with the unrespectable cost of equipment for data storage. System-on-Chip gives possible cost effective in reducing the bulky equipment and reliance on labor. This article discusses a new technique of degradation monitoring where an engine oil degradation model is used and translated into the logic gate based on the Least Square Method of statistical analysis. The degradation model is based on the optical properties where the percentage transmittance of light is varied due to the increase of contaminates contents in the engine oil at a certain period. A linear regression model is chosen in register-transfer level (RTL) development of the digital circuit design. In the algorithm development, the data set are collected at every one hour up to 300 hours and stored in a temporary register. Linear regression is implemented at every 5 data to obtain the degraded condition based on the variation of the slope

g factors of coexisting isomeric states in Pb-188

The $g$ factors of the ${12}^{+}$, {11}^{\ensuremath{-}}, and {8}^{\ensuremath{-}} isomeric states in $^{188}\mathrm{Pb}$ were measured using the time-differential perturbed angular distribution method as g({12}^{+})=\ensuremath{-}0.179(6), g({11}^{\ensuremath{-}})=+1.03(3), and g({8}^{\ensuremath{-}})=\ensuremath{-}0.037(7). The $g$ factor of the ${12}^{+}$ state follows the observed slight down-sloping evolution of the $g$ factors of the ${i}_{13/2}^{2}$ neutron spherical states with decreasing $N$. The $g$ factors of the {11}^{\ensuremath{-}} and {8}^{\ensuremath{-}} isomers proposed as oblate and prolate deformed states, respectively, were interpreted within the rotational model, using calculated and empirical $g$ factor values for the involved single-particle orbitals

Notch signaling during human T cell development

Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species. Here, we review our current understanding of how Notch signaling is activated and used during human T cell development. First, we set the stage by describing the developmental steps that make up human T cell development before describing the expression profiles of Notch receptors, ligands, and target genes during this process. To delineate stage-specific roles for Notch signaling during human T cell development, we subsequently try to interpret the functional Notch studies that have been performed in light of these expression profiles and compare this to its suggested role in the mouse

Preliminary Validation of the Digital Ulcer Clinical Assessment Score in Systemic Sclerosis

OBJECTIVE: To date, "healed/non-healed" and clinical judgment are the only available assessment tools for digital ulcers (DU) in patients with systemic sclerosis (SSc). The aim of our study is to examine a preliminary composite DU clinical assessment score (DUCAS) for SSc for face, content, and construct validity. METHODS: Patients with SSc presenting at least 1 finger DU were enrolled and assessed with the Health Assessment Questionnaire-Disability Index, Cochin scale, visual analog scale (VAS) for DU-related pain, patient global DU status, and global assessment as patient-reported outcomes (PRO), and physician VAS for DU status (phyGDU) as an SSc-DU expert physician/nurse measure. The DUCAS included 7 DU-related variables selected by a committee of SSc DU experts and weighted on a clinical basis. Face validity was examined by consensus and partial construct validity was tested through convergent correlation with other measures of hand function, using Spearman's correlations. A range of patients with SSc was examined. A linear regression model with backward stepwise analysis was used to determine the relationship of individual variables with the primary clinical parameter, phyGDU. RESULTS: Forty-four patients with SSc (9 males, mean age 55 ± 15 yrs, mean disease duration 9.9 ± 5.8 yrs) were enrolled in the study. Overall DUCAS showed significant positive correlations with all abovementioned PRO (r > 0.4, p < 0.01). When all scores and scales were modeled, only DUCAS significantly predicted phyGDU (r = 0.59, R² = 0.354, Akaike information criterion = 385.4). CONCLUSION: Preliminarily, we suggest that the DUCAS may be a new clinical score for SSc-related DU, having face and content validity and convergent/divergent correlations (construct validity). These early data suggest that this score deserves further evaluation

Readmission and death after an acute heart failure event: predictors and outcomes in sub-saharan africa: results from the thesus-hf registry

Aims: Contrary to elderly patients with ischaemic-related acute heart failure (AHF) typically enrolled in North American and European registries, patients enrolled in the sub-Saharan Africa Survey of Heart Failure (THESUS-HF) were middle-aged with AHF due primarily to non-ischaemic causes.We sought to describe factors prognostic of re-admission and death in this developing population. Methods and results: Prognostic models were developed from data collected on 1006 patients enrolled in THESUS-HF, a prospective registry of AHF patients in 12 hospitals in nine sub-Saharan African countries, mostly in Nigeria, Uganda, and South Africa. The main predictors of 60-day re-admission or death in a model excluding the geographic region were a history of malignancy and severe lung disease, admission systolic blood pressure, heart rate and signs of congestion (rales), kidney function (BUN), and echocardiographic ejection fraction. In a model including region, the Southern region had a higher risk. Age and admission sodium levels were not prognostic. Predictors of 180-day mortality included malignancy, severe lung disease, smoking history, systolic blood pressure, heart rate, and symptoms and signs of congestion (orthopnoea, peripheral oedema and rales) at admission, kidney dysfunction (BUN), anaemia, and HIV positivity. Discrimination was low for all models, similar to models for European and North American patients, suggesting that the main factors contributing to adverse outcomes are still unknown. Conclusion: Despite the differences in age and disease characteristics, the main predictors for 6 months mortality and combined 60 days re-admission and death are largely similar in sub-Saharan Africa as in the rest of the world, with some exceptions such as the association of the HIV status with mortality

Wearable textile patch antenna: challenges and future directions

Wearable antennas have grown in popularity in recent years as a result of their appealing features and prospects to actualize lightweight, compact, low-cost and adaptable wireless communications and surroundings. These antennas have to be conformal and made of lightweight materials in a low-profile arrangement when attached to various parts of the human body. Near-body operation of these antennas should be possible without degradation. When these characteristics are taken into account, the layout of wearable antennas become challenging, especially when textile substrates are investigated, high conductivity materials are used during manufacturing procedures and body binding scenarios have an impact on the design's performance. Several of these issues arise in the context of body-worn deployment, despite modest changes in magnitude between implementations. This paper examines the multiple issues and obstacles encountered in the construction of wearable antennas as well as the range of materials used, and the Specific Absorption Rate (SAR) effects employed as well as the bending scheme. An overview of the innovative features and their separate approaches to addressing the difficulties lately raised by work in this field conducted by the scientific community is provided as an appendix

Influence of tissue thermophysical characteristics and situ-cooling on the detection of breast cancer

This article presents a numerical simulation model using COMSOL software to study breast thermophysical properties. It analyzes tumor heat at different locations within the breast, records breast surface temperatures, investigates the effects of factors such as blood perfusion, size, depth, and thermal conductivity on breast size, and applies Pennes’ bioheat formula to illustrate thermal distribution on the breast skin surface. An analysis was conducted to examine how changes in tumor location depth, size, metabolism, blood flow, and heat conductivity affect breast skin surface temperature. The simulation model results showed that the highest variations in skin temperatures for breasts with tumors and without tumors can range from 2.58 °C to 0.274 °C. Further, large breast size with a large surface area consistently reduces the temperature variations on the skin and might have difficulty in yielding observable temperature contrast. For small breast sizes, however, heat from tumor sizes below 0.5 cm might be quite difficult to detect, while tumors located deep within the breast layers could not produce observable temperature variations. Motivated by the above interesting results, an emulation experiment was conducted to enhance the observable heat and temperature background contrast, using situ-cooling gel applied to silicon breasts, while the tumor source was emulated using LEDs. The experiment was used to evaluate the effectiveness of adding situ-cooling to the breast surface area, and to study the modulated effect of tumor size and depth. Experimental results showed that situ-cooling enhances thermal contrast in breast thermal images. For example, for a tumor location at a depth of 10 cm, a difference of 6 °C can still be achieved with situ-cooling gel applied, a feat that was not possible in the simulation model. Furthermore, changes in tumor size and location depth significantly impacted surface temperature distribution