Innovation, generative relationships and scaffolding structures: implications of a complexity perspective to innovation for public and private interventions

The linear model of innovation has been superseded by a variety of theoretical models that view the innovation process as systemic, complex, multi-level, multi-temporal, involving a plurality of heterogeneous economic agents. Accordingly, the emphasis of the policy discourse has changed over time. The focus has shifted from the direct public funding of basic research as an engine of innovation, to the creation of markets for knowledge goods, to, eventually, the acknowledgement that knowledge transfer very often requires direct interactions among innovating actors. In most cases, policy interventions attempt to facilitate the match between “demand” and “supply” of the knowledge needed to innovate. A complexity perspective calls for a different framing, one focused on the fostering of processes characterized by multiple agency levels, multiple temporal scales, ontological uncertainty and emergent outcomes. This contribution explores what it means to design interventions in support of innovation processes inspired by a complex systems perspective. It does so by analyzing two examples of coordinated interventions: a public policy funding innovating networks (with SMEs, research centers and university), and a private initiative, promoted by a network of medium-sized mechanical engineering firms, that supports innovation by means of technology brokerage. Relying on two unique datasets recording the interactions of the organizations involved in these interventions, social network analysis and qualitative research are combined in order to investigate network dynamics and the roles of specific actors in fostering innovation processes. Then, some general implications for the design of coordinated interventions supporting innovation in a complexity perspective are drawn

Histological evaluation of the exposure to 3,4-dichloroaniline in the estuarine mysid Mesopodopsis slabberi, under experimental conditions

This work presents an experimental approach to test Mesopodopsis slabberi as a potential indicator of pollution. The toxic effects of 3,4-dichloroaniline (DCA) on the histology of this estuarine mysid were studied. After an acclimation period of two days, the mysids were exposed to different sublethal 3,4-DCA concentrations (0.10, 0.30, 0.50, 0.90, 1.00, 1.10, 1.20, 1.30 and 1.40 mg/L), for a period of 48 h. Each concentration had seven replicates, and one control. After the exposure period, organisms were sacrificed and submitted to a standard histological procedure with some modifications. Histological effects were analyzed in several tissues and damages were found in organisms exposed to concentrations higher then 0.30 mg/L. Muscular tissue, cuticular lens and gonads were clearly affected by 3,4-DCA, presenting accumulations of this toxic substance and lesions on the structures

Histological evaluation of the exposure to 3,4-dichloroaniline in the estuarine mysid mesopodopsis slabberi, under experimental conditions

This work presents an experimental approach to test Mesopodopsis slabberi as a potential indicator of pollution. The toxic effects of 3,4-dichloroaniline (DCA) on the histology of this estuarine mysid were studied. After an acclimation period of two days, the mysids were exposed to different sublethal 3,4-DCA concentrations (0.10, 0.30, 0.50, 0.90, 1.00, 1.10, 1.20, 1.30 and 1.40 mg/L), for a period of 48 h. Each concentration had seven replicates, and one control. After the exposure period, organisms were sacrificed and submitted to a standard histological proce- dure with some modifications. Histological effects were analyzed in several tissues and damages were found in organisms exposed to concentrations higher then 0.30 mg/L. Muscular tissue, cuticular lens and gonads were clearly affected by 3,4-DCA, presenting accumulations of this toxic substance and lesions on the structures

Considerando a questão da interoperabilidade

This article concerns the path taken during my scientific research related to the construction and management of digital assets for the design, development, and management of databases, within the scope of the INET-md in Portugal. Its general objective is to facilitate the interoperability, Web dissemination, search, and retrieval of the INET-md's digital collections. This investigation aims to reinforce the alliance between the areas of Information Science and Computer Science. From the Information Science, it brings the applications used for organization, management, and publication of digital assets collections on the Web; and from the Computer Science, it brings syntactic concepts (metadata and protocols) to communicate and exchange data and semantic concepts (ontologies and semantic annotations) to describe data. Both types of concepts can promote interoperability between distinct digital repositories and platforms, providing improvements in information search and retrieval activities.Este artigo diz respeito ao caminho percorrido durante a minha investigação científica relacionada à construção e gestão de ativos digitais para a conceção, desenvolvimento e gestão de bases de dados, no âmbito do INET-md em Portugal. Seu objetivo geral é facilitar a interoperabilidade, disseminação na Web, busca e recuperação das coleções digitais do INET-md. Esta investigação visa reforçar a aliança entre as áreas de Ciência da Informação e Ciência da Computação. Da Ciência da Informação, traz os aplicativos utilizados para organização, gestão e publicação de acervos de ativos digitais na Web; e da Ciência da Computação, traz conceitos sintáticos (metadados e protocolos) para comunicar e trocar dados e conceitos semânticos (ontologias e anotações semânticas) para descrever dados. Ambos os tipos de conceitos podem promover a interoperabilidade entre distintos repositórios e plataformas digitais, proporcionando melhorias nas atividades de busca e recuperação de informações.publishe

A case of severe dermatitis in a patient with Polycythemia Vera during cytoreductive therapy

Polycythemia Vera (PV) is a Philadelphia-negative chronic myeloproliferative neoplasm (MPN) mainly characterized by erythrocytosis. In this report we describe a case of severe cutaneous toxicity in patients with PV treated with hydroxyurea. A 72-year-old woman diagnosed with PV with V617F mutation of JAK2 performed more than 10 years before and treated with hydroxyurea plus phlebotomies and low-dose ASA for about 7 years addressed our center for the appearance of serious dermatitis at the face symptomatic for severe itch. The patient underwent a dermatology visit with diagnosis of desquamative dermatitis due to iatrogenic cause related to the use of hydroxyurea. HU was stopped for a month with no improvement after a month of wash-out. Ruxolitinib was prescribed at a dose of 20 mg per day, in order to control hypercytosis and considering the severe intolerance to hydroxyurea. Ruxolitinib allowed not only to reduce the haematocrit, reaching the target value of 45%, and control thrombocytosis, but also to switch off the severe itch and to completely resolve skin toxicity

Nurses’ behavior regarding pain treatment in an emergency department: A single-center observational study

Purpose: The aim of this prospective study was to assess the behavior of emergency department (ED) nurses with regard to pain and their role in pain management in a real-life clinical setting. Methods: A total of 509 consecutive patients were enrolled during a 6-week period. A case-report form was used to collect data on nurses’ approaches to pain, time to analgesia provision, and patient-perceived quality of analgesia. Results: Triage nurses actively inquired about pain in almost every case, but they did not estimate pain intensity in a third of patients. In the majority of cases, triage nurses did not report pain-related findings to the physician, who was the only professional that could prescribe analgesia to patients. The assignment of the color-coding of triage by nurses appears to be related to the perceived severity of the clinical case and a more comprehensive evaluation of pain. More than half of patients were at least fairly satisfied with analgesia. Conclusion: Pain is increasingly screened during triage, but its comprehensive assessment and management still lack systematic application. We believe that further education and implementation of analgesia protocols may empower nurses to manage ED patients’ pain more effectively and in a more timely manner