10,991 research outputs found
Effect of hyperthermia on prognosis after acute ischemic stroke
<p><b>Background and Purpose:</b> Experimental studies have shown that hyperthermia is a determinant of poor outcome after ischemic stroke. Clinical studies evaluating the effect of temperature on poststroke outcome have, however, been limited by small sample sizes. We sought to evaluate the effect of temperature and timing of hyperthermia on outcome after ischemic stroke.</p>
<p><b>Methods:</b> Data of 5305 patients in acute stroke trials from the Virtual International Stroke Trials Archive (VISTA) data set were analyzed. Data for temperatures at baseline, eighth, 24th, 48th, and 72nd hours, and seventh day were assessed in relation to outcome (poor versus good) based on the modified Rankin Scale at 3 months. Hyperthermia was defined as temperature >37.2°C and poor outcome as 90-day modified Rankin Scale >2. Hazard ratios with 95% CIs were reported for hyperthermia in relation to the outcome. Logistic regression models, in relation to hyperthermia, were fitted for a set of preselected covariates at different time points to identify predictors/determinants of hyperthermia.</p>
<p><b>Results:</b> The average age of patients was 68.0±11.9 years, 2380 (44.9%) were females, and 42.3% (2233) received thrombolysis using recombinant tissue plasminogen activator. After adjustment, hyperthermia was a statistically significant predictor of poor outcome. The hazard ratios (95% CI) for poor outcome in relation to hyperthermia at different time points were: baseline 1.2 (1.0 to 1.4), eighth hour 1.7 (1.2 to 2.2), 24th hour 1.5 (1.2 to 1.9), 48th hour 2.0 (1.5 to 2.6), 72nd hour 2.2 (1.7 to 2.9), and seventh day 2.7 (2.0 to 3.8). Gender, stroke severity (National Institutes of Health Stroke Scale score >16), white blood cell count, and antibiotic use were significantly associated with hyperthermia (P≤0.01).</p>
<p><b>Conclusions:</b> Hyperthermia, in acute ischemic stroke, is associated with a poor clinical outcome. The later the hyperthermia occurs within the first week, the worse the prognosis. Severity of stroke and inflammation are important determinants of hyperthermia after ischemic stroke. In patients with acute ischemic stroke, aggressive measures to prevent and treat hyperthermia could improve the clinical outcomes.</p>
Hot Spots on the Fermi Surface of Bi2212: Stripes versus Superstructure
In a recent paper Saini et al. have reported evidence for a pseudogap around
(pi,0) at room temperature in the optimally doped superconductor Bi2212. This
result is in contradiction with previous ARPES measurements. Furthermore they
observed at certain points on the Fermi surface hot spots of high spectral
intensity which they relate to the existence of stripes in the CuO planes. They
also claim to have identified a new electronic band along Gamma-M1 whose one
dimensional character provides further evidence for stripes. We demonstrate in
this Comment that all the measured features can be simply understood by
correctly considering the superstructure (umklapp) and shadow bands which occur
in Bi2212.Comment: 1 page, revtex, 1 encapsulated postscript figure (color
Large-amplitude electron-acoustic solitons in a dusty plasma with kappa-distributed electrons
The Sagdeev pseudopotential method is used to investigate the occurrence and
the dynamics of fully nonlinear electrostatic solitary structures in a plasma
containing suprathermal hot electrons, in the presence of massive charged dust
particles in the background. The soliton existence domain is delineated, and
its parametric dependence on different physical parameters is clarified.Comment: 3 pages, 1 figure, presented as a poster at the 6th International
Conference on the Physics of Dusty Plasmas (ICPDP6), Garmisch-Partenkirchen,
Germany, 201
Dark energy FRW cosmology - dynamical system reconstruction
We develop a simple method of dark energy reconstruction using a geometrical
form of the luminosity-distance relation. In this method the FRW dynamical
system with dark energy is reconstructed instead of the equation of state
parameter. We give several examples which illustrate the usefulness of our
method in fitting the redshift transition from the decelerating to accelerating
phase as the value of the Hubble function at the transition.Comment: Talk presented at Spanish Relativity Meeting 2007, Puerto de la Cruz,
Tenerife, Spain, 10-14 September 200
The 2022 Conservative leadership campaign and post-racial gatekeeping
The Conservative party leadership contest that took place in the summer of 2022 was unprecedented for, amongst other things, its level of ethnic diversity. This paper argues that this doesn’t indicate a sharp, contemporary liberal turn within the party. It argues the opposite, in fact, that recent senior ethnic minority cabinet members and leadership contenders represent some of the party’s most right-wing ideologues in years. Through critical discourse analysis of narrative related to race, borders, immigration and the ‘nation’ in selected media appearances made by ethnic minority leadership contenders Rishi Sunak, Sajid Javid, Nadhim Zahawi, Suella Braverman and Kemi Badenoch as part of their campaigns, this paper positions these individuals – in distinct yet interrelated ways – as ethnic minority post-racial gatekeepers, continuing yet intensifying a long trend within the Conservative party of the reproduction of the racial status quo legitimised through nominal ethnic minority representation
Structure and electronic properties of transition-metal/Mg bimetallic clusters at realistic temperatures and oxygen partial pressures
Composition, atomic structure, and electronic properties of TMMgO
clusters (TM = Cr, Ni, Fe, Co, ) at realistic temperature and
partial oxygen pressure conditions are explored using the
{\em ab initio} atomistic thermodynamics approach. The low-energy isomers of
the different clusters are identified using a massively parallel cascade
genetic algorithm at the hybrid density-functional level of theory. On
analyzing a large set of data, we find that the fundamental gap E
of the thermodynamically stable clusters are strongly affected by the presence
of Mg-coordinated O moieties. In contrast, the nature of the transition
metal does not play a significant role in determining E. Using
E of a cluster as a descriptor of its redox properties, our
finding is against the conventional belief that the transition metal plays the
key role in determining the electronic and therefore chemical properties of the
clusters. High reactivity may be correlated more strongly with oxygen content
in the cluster than with any specific TM type.Comment: 7 pages, 5 figure
Local structure of REFeAsO (RE=La, Pr, Nd, Sm) oxypnictides studied by Fe K-edge EXAFS
Local structure of REOFeAs (RE=La, Pr, Nd, Sm) system has been studied as a
function of chemical pressure varied due to different rare-earth size. Fe
K-edge extended X-ray absorption fine structure (EXAFS) measurements in the
fluorescence mode has permitted to compare systematically the inter-atomic
distances and their mean square relative displacements (MSRD). We find that the
Fe-As bond length and the corresponding MSRD hardly show any change, suggesting
the strongly covalent nature of this bond, while the Fe-Fe and Fe-RE bond
lengths decrease with decreasing rare earth size. The results provide important
information on the atomic correlations that could have direct implication on
the superconductivity and magnetism of REOFeAs system, with the chemical
pressure being a key ingredient
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