Factors associated with adverse outcome among hospitalized patients with moderate to severe COVID-19

Aims. To consider factors associated with adverse outcome among hospitalized patients with moderate and severe COVID-19.Materials and methods. Data from 345 case histories of adult patients hospitalized with moderate to severe COVID-19 were analyzed in a single-center retrospective study. Characteristics by sex, age, number of days from disease onset to admission to hospital, duration of hospitalization, duration of disease, population characteristics by medical history of comorbidities and self-medication, outcome of hospitalization and medical technologies used in hospital conditions were given for the whole cohort of patients. All parameters were analyzed using descriptive statistics methods. Qualitative variables are given in absolute (n) and relative (%) values with 95% confidence interval. Continuous variables were presented as median and quartiles. Risk factors for mortality were determined across groups using the χ2  criterion and odds ratio.Results. There was no demonstrated effect of gender, degree of pulmonary tissue lesions on computed tomography data, or time of initiation of respiratory support on disease outcome. At the same time, the age older than 65 years as well as neoplasms, type 2 diabetes mellitus, dementia, Stage 3 arterial hypertension, chronic heart failure, coronary heart disease, myocardial infarction and stroke history, chronic obstructive pulmonary disease, bronchiectatic disease, urogenital diseases were the predictors of unfavorable outcome in patients with moderate and severe COVID-19 form. Prehospital use of antiplatelet agents, direct and indirect oral anticoagulants, drugs affecting the renin-angiotensin system, systemic glucocorticosteroids, antibiotics, antiviral drugs, and analgesics was associated with a decrease in the mortality rate in patients with moderate-to-severe COVID-19, as well as timely use of pronposition and transfer to intensive care unit.Conclusions. Our findings are partially consistent with previous reports on the effect of risk factors on COVID-19 outcomes

Новый исходный материал для создания перспективных сортов дыни

Relevance. The creation of varieties with a complex of economically valuable traits, resistant to biotic and abiotic environmental factors, is the main direction in melon breeding. The market for vegetables and melons and gourds is very dynamic, the demands for varieties are constantly changing, therefore, it is necessary to introduce new varieties with high taste and commercial qualities, as well as capable of producing high yields in a changing climate. The aim of the work is to produce a new melon starting material for use in the breeding process.Materials and methods. At the Bikovskaya cucurbits breeding experimental station – branch of the Federal state budgetary scientific institution "Federal scientific vegetable center", research was carried out from 2018 to 2020. The object of research is samples from the collection of VIR, foreign and domestic selection, hybrid combinations obtained as a result of intervarietal hybridization. Collection samples of melon were studied in the nursery of the source material: 84 samples from the VIR collection, 26 samples of domestic and foreign selection were studied.Results. As a result of the research, samples of melon with economically valuable traits were identified that meet the requirements of selection. Paired crosses with zoned varieties of local selection were carried out with them. As a result of hybridization, hybrid combinations F1 were obtained, from which the best ones were selected for further breeding work. The obtained collection samples and hybrid combinations were evaluated in terms of taste, yield, resistance to environmental abiofactors, dry matter content, large-fruited, attractive color of the fruit and pulp As a result received a new source material for the selection of new varieties and hybrids of melons with valuable economic traits. The resulting hybrid combinations of F1 melon were tested against an infectious background. Hybrid combinations with the best performance will be further studied in a breeding nursery.Актуальность. Создание сортов, обладающих комплексом хозяйственно ценных признаков, устойчивых к биотическим и абиотическим факторам среды, является главным направлением в селекционной работе по дыне. Рынок овощной и бахчевой продукции очень динамичен, запросы на сорта постоянно меняются, поэтому требуется внедрение новых сортов, обладающих высокими вкусовыми и товарными качествами, а также способных давать высокие урожаи в условиях изменяющегося климата. Цель работы – создать новый исходный материал дыни, обладающий параметрами, необходимыми селекционеру согласно разработанной модели сорта.Материалы и методы. Объект исследования – образцы из коллекции ВИР, зарубежной и отечественной селекции, гибридные комбинации, полученные в результате межсортовой гибридизации. Исследования проводили на Быковской селекционной опытной станции – филиале ФГБНУ ФНЦО в 2018-2020 годах. В питомнике исходного материала изучали коллекционные образцы дыни: 84 образца из коллекции ВИР, 26 образцов отечественной и иностранной селекции. Оценивали полученные коллекционные образцы и гибридные комбинации по вкусовым качествам, содержанию сухого вещества, урожайности, устойчивости к абиофакторам среды, крупноплодности, привлекательной окраске плода и мякоти.Результаты. Выделены образцы дыни с хозяйственно ценными признаками, которые отвечают требованиям селекции. Провели парные скрещивания с районированными сортами местной селекции. В результате гибридизации получены гибридные комбинации F1, из которых отобраны лучшие для дальнейшей селекционной работы. В итоге исследований получен новый исходный материал для селекции новых сортов и гибридов дыни с ценными хозяйственными признаками. Полученные гибридные комбинации F1 дыни были испытаны на инфекционном фоне. Гибридные комбинации с лучшими показателями в дальнейшем будут изучены в селекционном питомнике

『新撰万葉集』の風物表現に関する和漢比較研究——上巻の和歌と漢詩を中心に

《新撰万叶集》成立于“国风暗黑时代”向“和风复兴时代”转变的过程中，在日本古典文学史上占有极其重要的地位。该集由上下两卷组成，其中上卷的每一首和歌的左边都附有一首七言绝句，可以说包含着编撰者特殊的编撰意图。该集这种“和汉共存”的特点不断吸引着和汉比较文学学界的关注。 至今为止的研究主要是从“和汉共存”出发，围绕该集的和歌和汉诗的表达、抑或是和歌和汉诗的关系论而展开的。为了更加客观地把握该集在日本古典文学史上的地位，我们要对“和汉共存”这一点开展进一步的研究。本论文把该集的汉诗作者看成该集和歌的鉴赏者之一。并由此出发，摒弃一直以来对本集的汉诗所持的偏见，把《新撰万叶集》上卷的和歌和其相应的汉诗...「国風暗黒時代」から「和風復興時代」へと進行していった過程に成立された『新撰万葉集』（以下は「本集」とも）は、日本古典文学史上で極めて重要な地位を占めている。本集は上下二巻からなるが、上巻は和歌とともにその左に七言絶句が付されているもので、特別な編纂意図が含まれるに違いない。その「和漢共存」という点で和漢比較文学学界の注目を引き続く。 今日まで、「和漢共存」から主に本集における和漢詩歌の表現や和歌と漢詩との関係論をめぐって行われてきたが、本集の日本古典文学史における地位をより客観的に把握するために、更なる研究が期待される。本論は、本集の漢詩作者は本集の和歌の鑑賞者でもあることから出発し、従来の本集の漢詩に対する偏見に挑み、『新撰万葉集』上巻の和歌とそれに付される漢詩を、平安人の作詩を中心とする文学上の訓練とその成果の総決算の縮図の一つと見なす。その認識の上で、先学の研究成果を踏まえながら...学位：文学硕士院系专业：外文学院日本语言文学系_日语语言文学学号：1222007115181

RD39 Status Report 2009

RD39 Status Report 2009. CERN RD39 Collaboration is developing super-radiation hard cryogenic silicon detectors for applications of LHC experiments and their future upgrades. The activities of RD39 Collaboration were focused in 2009 on concept of charge injected detector (CID)

Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.Comment: 15 pages, 11 figures. Published in European Physical Journal

Project Method as a Way of the Formation of Student’ Professional and Language Competencies of Non-Linguistic High School

В статье раскрывается потенциал дисциплины «Иностранный язык» для формирования профессиональных и языковых компетенций студентов бакалавриата направления «Биология» Балтийского федерального университета имени И. Канта посредством применения проектного метода. Статья содержит описание проведенного совместного проекта Ресурсным центром иностранных языков и Ботаническим садом.The article reveals the potential of the discipline «Foreign language» to form professional and language competencies of Bachelor students with Biology major at I. Kant Baltic Federal university applying the project method. The article contains the description of the project organized by Resource centre of foreign languages and Botanical Garden

Progress in Diamond Detector Development

Detectors based on Chemical Vapor Deposition (CVD) diamond have been used successfully in Luminosity and Beam Condition Monitors (BCM) in the highest radiation areas of the LHC. Future experiments at CERN will accumulate an order of magnitude larger fluence. As a result, an enormous effort is underway to identify detector materials that can operate under fluences of 1 · 1016 n cm−2 and 1 · 1017 n cm−2. Diamond is one candidate due to its large displacement energy that enhances its radiation tolerance. Over the last 30 years the RD42 collaboration has constructed diamond detectors in CVD diamond with a planar geometry and with a 3D geometry to extend the material's radiation tolerance. The 3D cells in these detectors have a size of 50 µm×50 µm with columns of 2.6 µm in diameter and 100 µm×150 µm with columns of 4.6 µm in diameter. Here we present the latest beam test results from planar and 3D diamond pixel detectors