Hyper-complex four-manifolds from the Tzitz\'eica equation

It is shown how solutions to the Tzitz\'eica equation can be used to construct a family of (pseudo) hyper-complex metrics in four dimensions.Comment: To be published in J.Math.Phy

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder

Mammalian microRNAs are emerging as key regulators of the development and function of the immune system. Here, we report a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide (LPS) correlated with granulocyte/monocyte (GM) expansion. Demonstrating the sufficiency of miR-155 to drive GM expansion, enforced expression in mouse bone marrow cells caused GM proliferation in a manner reminiscent of LPS treatment. However, the miR-155–induced GM populations displayed pathological features characteristic of myeloid neoplasia. Of possible relevance to human disease, miR-155 was found to be overexpressed in the bone marrow of patients with certain subtypes of acute myeloid leukemia (AML). Furthermore, miR-155 repressed a subset of genes implicated in hematopoietic development and disease. These data implicate miR-155 as a contributor to physiological GM expansion during inflammation and to certain pathological features associated with AML, emphasizing the importance of proper miR-155 regulation in developing myeloid cells during times of inflammatory stress

The technologies of using generating gas in cogeneration installations

The paper discusses the experimental setup of gas generation from wood waste. The obtained experimental dependence of the composition of the generator gas temperature at the exit of the gasifier.В работе рассмотрена экспериментальная установка генерации газа из древесных отходов. Получены экспериментальные зависимости состава генераторного газа от температуры на выходе из газогенератора

Air ions induced aerosol sensing by eye-safe LIDAR

Low concentrations aerosols quantification is rather challenging for LIDAR instruments due to eye-safety restrictions so high energy pulses cannot be utilized to improve the sensitivity. Highly sensitive but eye-save LIDAR has been developed for the quantification of the water droplet aerosol which was induced by air ions. Few days sensing of aerosols in closed tunnel revealed a strong correlation between air optical transparency (LIDAR measurements) and concentrations of positive/negative ions (ion counter Sapphir 3-M). The correlation coefficient was observed to be almost unity for the air transparency signal and air ions unipolarity coefficient. High sensitivity of the water droplet aerosol quantification makes the developed eye-safe LIDAR a perspective instrument for space resolved measurements of the air ions distribution. Space and time resolved measurements of air ions exhalation can be a new instrument for tectonic activity study including new earthquake forecasting indicators search

Diagnosis and treatment of muscle pain according to Tipaldos (literature review)

This review contents the information on the theory of the structure and mechanisms of damage to the body fascial system, proposed by American osteopath S. Tipaldos and named by him the Fascial Distortion Model (FDM), as well as on the original method of diagnosis and treatment of muscle pain syndromes associated with fascial damage (distortion). The author describes classifications of connective tissue and fascial structures, created by S.  Tipaldos, which are based on anatomical and functional features that determine the role of each type of fascia in compensating for various types of external influences. The conditions, mechanisms of formation and characteristics of six types of fascial lesions identified by S. Tipaldos are considered in detail: triggerband, herniated triggerpoint, continuum distortion, folding distortion, cylinder distortion, tectonic fixation. All elements of the fascial distortions diagnosis are discussed in detail, including the specification of complaints (characteristics of pain syndrome), anamnesis (history of the pain onset and its development) and an objective examination (the actual diagnostic techniques). At the same time, the special role of the patient’s description of his own painful sensations with the help of specific gestures and movements, called «body language», is emphasized. The principles and some methods of therapeutic effects used in FDM-therapy, indications and contraindications for the use of the considered manual techniques, possible side reactions that may occur during manipulation or after a session of FDMtherapy are presented. Particular attention is paid to  the evidence base of FDM therapy effectiveness in comparison with traditional methods of myofascial pain syndromes manual treatment: the results of controlled studies by foreign authors, confirming the new technique effectiveness in the treatment of certain muscle algic phenomena types, are considered

Strominger--Yau--Zaslow geometry, Affine Spheres and Painlev\'e III

We give a gauge invariant characterisation of the elliptic affine sphere equation and the closely related Tzitz\'eica equation as reductions of real forms of SL(3, \C) anti--self--dual Yang--Mills equations by two translations, or equivalently as a special case of the Hitchin equation. We use the Loftin--Yau--Zaslow construction to give an explicit expression for a six--real dimensional semi--flat Calabi--Yau metric in terms of a solution to the affine-sphere equation and show how a subclass of such metrics arises from 3rd Painlev\'e transcendents.Comment: 38 pages. Final version. To appear in Communications in Mathematical Physic

Tungstate Based Ceramics Obtained By Spark Plasma Sintering Method – Possible Material for Consolidation of Radioactive Wastes’ Components

The Spark Plasma Sintering method was used to produce high-density ceramics from tungstates SrWO4 and NaNd(WO4)2 with scheelite structure. These compounds are proposed as possible matrices for the consolidation of radwaste components. Powder samples were obtained by coprecipitation method and studied by X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). After sintering, the samples retained their phase identity (scheelite structure). The total duration of sintering was ∼ 13-15 min, the relative density was reached ∼ 92, 99%. Keywords: Tungstates, RW, Spark Plasma Sintering, high density, microstructur

Investigation of the effect of the grain sizes on the dynamic strength of the fine-grained alumina ceramics obtained by Spark Plasma Sintering

The results of dynamic strength tests of the alumina ceramics with various grain sizes are presented. The ceramics were obtained by Spark Plasma Sintering (SPS) of industrial submicron and fine Al2O3 powders. The heating up was performed with the rate of 10 oC/min; the grain sizes in the ceramics was controlled by varying the SPS temperature and the heating rate as well as by varying the initial sizes of the Al2O3 particles in the powders. The ceramics had a high density (over 98%) and a uniform fine-grained microstructure (the mean grain sizes varied from 0.8 to 13.4 mkm). The dynamic compressing tests were carried out by modified Kolsky method with using split Hopkinson pressure bar. The tests were performed at room temperature using a 20-mm PG-20 gas gun with the strain rate of ~10^3 s-1. The dependence of the dynamic ultimate strength of alumina on the grain size was found for the first time to have a non-monotonous character (with a maximum). The maximum value of the dynamic ultimate compression strength (SY = 1060 MPa) was provided at the mean grain size of ~2.9-3 mkm. The reduction of SY for alumina in the range of submicron grain sizes was shown to originate from the reduction of the relative density of the ceramics sintered at lower SPS temperatures.Comment: 16 pages, 1 table, 6 figures, 28 reference

NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies

MicroRNA miR-146a has been implicated as a negative feedback regulator of NF-κB activation. Knockout of the miR-146a gene in C57BL/6 mice leads to histologically and immunophenotypically defined myeloid sarcomas and some lymphomas. The sarcomas are transplantable to immunologically compromised hosts, showing that they are true malignancies. The animals also exhibit chronic myeloproliferation in their bone marrow. Spleen and marrow cells show increased transcription of NF-κB–regulated genes and tumors have higher nuclear p65. Genetic ablation of NF-κB p50 suppresses the myeloproliferation, showing that dysregulation of NF-κB is responsible for the myeloproliferative disease