Early and Late Response and Glucocorticoid-Sparing Effect of Belimumab in Patients with Systemic Lupus Erythematosus with Joint and Skin Manifestations: Results from the Belimumab in Real Life Setting Study—Joint and Skin (BeRLiSS-JS)

Aim. To assess the efficacy of belimumab in joint and skin manifestations in a nationwide cohort of patients with SLE. Methods. All patients with skin and joint involvement enrolled in the BeRLiSS cohort were considered. Belimumab (intravenous, 10 mg/kg) effectiveness in joint and skin manifestations was assessed by DAS28 and CLASI, respectively. Attainment and predictors of DAS28 remission (<2.6) and LDA (≥2.6, ≤3.2), CLASI = 0, 1, and improvement in DAS28 and CLASI indices ≥20%, ≥50%, and ≥70% were evaluated at 6, 12, 24, and 36 months. Results. DAS28 < 2.6 was achieved by 46%, 57%, and 71% of patients at 6, 12, and 24 months, respectively. CLASI = 0 was achieved by 36%, 48%, and 62% of patients at 6, 12, and 24 months, respectively. Belimumab showed a glucocorticoid-sparing effect, being glucocorticoid-free at 8.5%, 15.4%, 25.6%, and 31.6% of patients at 6, 12, 24, and 36 months, respectively. Patients achieving DAS-LDA and CLASI-50 at 6 months had a higher probability of remission at 12 months compared with those who did not (p = 0.034 and p = 0.028, respectively). Conclusions. Belimumab led to clinical improvement in a significant proportion of patients with joint or skin involvement in a real-life setting and was associated with a glucocorticoid-sparing effect. A significant proportion of patients with a partial response at 6 months achieved remission later on during follow-up

Elementary Processes, Transport and Kinetics of Molecular Plasmas

Vibrationally resolved cross-sections have been obtained, in classical and semiclassical approximations, for electron impact induced dissociation, excitation, ionization of molecules and for dissociation and vibrational deactivation in atom–diatom collisions. The influence of atomic excited states on the transport properties of a hydrogen plasma in thermodynamic equilibrium has been investigated systematically. Finally, different approaches for the simulation of negative ion sources through the coupling of vibrational and electron kinetics are presented

Geotechnical aspects of the Mw6.2 2011 Christchurch New Zealand Earthquake

The 22 February 2011, Mw6.2 Christchurch earthquake is the most costly earthquake to affect New Zealand, causing an estimated 181 fatalities and severely damaging thousands of residential and commercial buildings. This paper presents a summary of some of the observations made by the NSF-sponsored GEER Team regarding the geotechnical/geologic aspects of this earthquake. The Team focused on documenting the occurrence and severity of liquefaction and lateral spreading, performance of building and bridge foundations, buried pipelines and levees, and significant rockfalls and landslides. Liquefaction was pervasive and caused extensive damage to residential properties, water and wastewater networks, high-rise buildings, and bridges. Entire neighborhoods subsided, resulting in flooding that caused further damage. Additionally, liquefaction and lateral spreading resulted in damage to bridges and to stretches of levees along the Waimakariri and Kaiapoi Rivers. Rockfalls and landslides in the Port Hills damaged several homes and caused several fatalities