Medios y submedios en el sector intermareal de la ensenada de San Simón. Ría de Vigo (Pontevedra): secuencias sedimentarias características

La ensenada de San Simón, forma la parte más interna de la ría de Vigo. Su sector intermareal está constituido por dos medios sedimentarios bien diferenciados: un estuario y una llanura intermareal. El paso de uno a otro es de forma gradual e irregular. Los submedios que en ellos se desarrollan son: marisma salobre, llanura de Zostera, llanura interna de Arenicola, llanura arenosa y canales de drenaje, para la zona intermareal. Para la zona estuarina, los submedios quedan diferenciados en función de su dinámica: la mitad más interna con desarrollo de barras arenosas transversas y la más externa con barras arenosas linguoides y oblicuas. Se describen las secuencias teóricas en tres unidades características; borde del canal estuarino, rampa de flujo y llanura interm

Medios y submedios en el sector intermareal de la ensenada de San Simón. Ría de Vigo (Pontevedra): secuencias sedimentarias características

La ensenada de San Simón, forma la parte más interna de la ría de Vigo. Su sector intermareal está constituido por dos medios sedimentarios bien diferenciados: un estuario y una llanura intermareal. El paso de uno a otro es de forma gradual e irregular. Los submedios que en ellos se desarrollan son: marisma salobre, llanura de Zostera, llanura interna de Arenicola, llanura arenosa y canales de drenaje, para la zona intermareal. Para la zona estuarina, los submedios quedan diferenciados en función de su dinámica: la mitad más interna con desarrollo de barras arenosas transversas y la más externa con barras arenosas linguoides y oblicuas. Se describen las secuencias teóricas en tres unidades características; borde del canal estuarino, rampa de flujo y llanura interm

Sedimentological study of Galicia coast: JI. Relation-ship between the distribution of grain size and the biogenic carbonate content in Pontevedra and Arousa beaches.

[Resumen] Dentro del estudio de los diferentes medios de depósitos sedimentarios de las Rías Gallegas, se presenta una distribución del contenido en carbonatos biogénicos así como las variaciones granulométricas del sector intermareal de las playas de Pontevedra y Arosa. Los puntos de muestreo fueron seleccionados en función del grado de exposición y condiciones de alta energía (zonas abiertas), y de baja energía (zonas interiores). Se levantaron perfiles topográficos en un total de 15 playas; en cada perfil se tomaron, como promedio, 3 muestras comprendidas entre los niveles de pleamar y bajamar, considerando puntos equivalentes para cada una de las playas. Los resultados obtenidos muestran en general una homogeneidad en cuanto a tamaño de grano, del orden de 2 a 0.25 mm, es decir, fracción media-gruesa. Es constante la presencia de los valores más finos hacia la parte alta de cada perfil. El contenido en carbonatos oscila entre un 20 y un 40 O/o para aquellas estaciones de muestreo situadas en zonas abiertas, mientras que en aquellas otras situadas hacia el interior su contenido no sobrepasa, en general, el 5 o/o. Estos valores pueden ser interpretados como resultado de la ubicación geográfica y su dinámica, actuando como indicador que puede ser extensible al resto del litoral gallego.[Abstract] A distribution of the biogenic carbonatic content and grain size for the intertidal zone of the beaches of the Ria de Pontevedra and Ria de Arosa is presented in this papero Sampling stations were chosen to reflect the different exposures and energy: high energy (open zones) and low energy (inner zones). Morphology of 15 beaches was determined by topographic profiling, with an average of 3 samples between high-water mark and low-water mark in each profile. This way, equivalent points in the different beaches can be compared. The results show a general grain-size homogneity with a predominance of the medium-coarse fraction, about 2-0.25 mm. A finer grain size is usually found in the upper part of each profile. The carbonatic content range is 20-40 O/o in open zones, whereas the content is less than 5 O/o in beaches towards the inner zones. This values are significant with respect to the geographical position of the beaches in each ria and the different dynamics. They are, then, an index that could be applied to the study of the whole Galician coast

Climate fluctuations during the Holocene in NW Iberia: high and low latitude linkages

International audienceHigh resolution benthic foraminiferal oxygen and carbon stable isotopes (?18O, ?13C) from core EUGC-3B are used here to infer rapid climatic changes for the last 8500 yr in the Ría de Muros (NW Iberian Margin). Benthic foraminiferal ?18O and ?13C potentially register migrations in the position of the hydrographic front formed between two different intermediate water masses: Eastern North Atlantic Central Water of subpolar origin (ENACWsp), and subtropical origin (ENACWsp). The isotopic records have been compared with two well established North Atlantic marine Holocene paleoceanographic records from low (Sea Surface Temperatures anomalies off Cape Blanc, NW Africa) and high latitudes (Hematite Stained Grains percentage, subpolar North Atlantic). This comparison clearly demonstrates that there is a strong link between high- and low-latitude climatic perturbations at centennial-millennial time scales during the Holocene. Spectral analyses also points at a pole-to-equator propagation of the so-called 1500 yr cycles. Our results demonstrate that during the Holocene, the NW Iberian Margin has undergone a series of cold episodes which are likely triggered at high latitudes in the North Atlantic and are rapidly propagated towards lower latitudes. Conceivably, the propagation of these rapid climatic changes involves a shift of atmospheric and oceanic circulatory systems and so a migration of the hydrographical fronts and water masses all along the North Atlantic area

El complejo de playa-lagoon de Corrubedo y los submedios característicos. Galicia, NW. España

El complejo costero de Corrubedo (Provincia de La Coruña) es un sistema playa-barrera-lagoon, en avanzado estado de evolución. En el presente trabajo se distinguen 8 subambientes de sedimentación y se describen los procesos actuantes y los sedimentos característicos de cada uno de ellos. Se distinguen también las etapas de evolución en época reciente del sistema, y se proponen los posibles mecanismos que la causaron

El complejo de playa-lagoon de Corrubedo y los submedios característicos. Galicia, NW. España

El complejo costero de Corrubedo (Provincia de La Coruña) es un sistema playa-barrera-lagoon, en avanzado estado de evolución. En el presente trabajo se distinguen 8 subambientes de sedimentación y se describen los procesos actuantes y los sedimentos característicos de cada uno de ellos. Se distinguen también las etapas de evolución en época reciente del sistema, y se proponen los posibles mecanismos que la causaron

Value of Early Circulating Tumor Cells Dynamics to Estimate Docetaxel Benefit in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Patients

Biomarcadores; Células tumorales circulantes; DocetaxelBiomarkers; Circulating tumor cells; DocetaxelBiomarcadors; Cèl·lules tumorals circulants; DocetaxelCirculating tumor cell (CTC) enumeration and changes following treatment have been demonstrated to be superior to PSA response in determining mCRPC outcome in patients receiving AR signaling inhibitors but not taxanes. We carried out a pooled analysis of two prospective studies in mCRPC patients treated with docetaxel. CTCs were measured at baseline and 3–6 weeks post treatment initiation. Cox regression models were constructed to compare 6-month radiographical progression-free survival (rPFS), CTCs and PSA changes predicting outcome. Among the subjects, 80 and 52 patients had evaluable baseline and post-treatment CTC counts, respectively. A significant association of higher baseline CTC count with worse overall survival (OS), PFS and time to PSA progression (TTPP) was observed. While CTC response at 3–6 weeks (CTC conversion (from ≥5 to <5 CTCs), CTC30 (≥30% decline in CTC) or CTC0 (decline to 0 CTC)) and 6-month rPFS were significantly associated with OS (all p < 0.005), the association was not significant for PSA30 or PSA50 response. CTC and PSA response were discordant in over 50% of cases, with outcome driven by CTC response in these patients. The c-index values for OS were superior for early CTC changes compared to PSA response endpoints, and similar to 6-month rPFS. Early CTC declines were good predictors of improved outcomes in mCRPC patients treated with docetaxel in this small study, offering a superior and/or earlier estimation of docetaxel benefit in comparison to PSA or rPFS that merits further confirmation in larger studies.The results reported here were generated as part of two academic studies supported by various grants. The funding sources had no role in study design, data analysis, data interpretation or writing of the report. R.L., D.L. and D.O. had full access to all of the data and had final responsibility for the decision to submit for publication. This project represents independent research supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at The Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care

Modality Attention and Sampling Enables Deep Learning with Heterogeneous Marker Combinations in Fluorescence Microscopy

Fluorescence microscopy allows for a detailed inspection of cells, cellular networks, and anatomical landmarks by staining with a variety of carefully-selected markers visualized as color channels. Quantitative characterization of structures in acquired images often relies on automatic image analysis methods. Despite the success of deep learning methods in other vision applications, their potential for fluorescence image analysis remains underexploited. One reason lies in the considerable workload required to train accurate models, which are normally specific for a given combination of markers, and therefore applicable to a very restricted number of experimental settings. We herein propose Marker Sampling and Excite, a neural network approach with a modality sampling strategy and a novel attention module that together enable ($i$) flexible training with heterogeneous datasets with combinations of markers and ($ii$) successful utility of learned models on arbitrary subsets of markers prospectively. We show that our single neural network solution performs comparably to an upper bound scenario where an ensemble of many networks is na\"ively trained for each possible marker combination separately. In addition, we demonstrate the feasibility of our framework in high-throughput biological analysis by revising a recent quantitative characterization of bone marrow vasculature in 3D confocal microscopy datasets. Not only can our work substantially ameliorate the use of deep learning in fluorescence microscopy analysis, but it can also be utilized in other fields with incomplete data acquisitions and missing modalities.Comment: 17 pages, 5 figures, 3 pages supplement (3 figures

Publisher Correction: Sensory attenuation in Parkinson's disease is related to disease severity and dopamine dose.

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