The impact of non-LTE effects and granulation inhomogeneities on the derived iron and oxygen abundances in metal-poor halo stars

This paper presents the results of a detailed theoretical investigation of the impact of non-LTE effects and of granulation inhomogeneities on the derived iron and oxygen abundances in the metal-poor halo subgiant HD140283. Our analysis is based on both the `classical' one-dimensional (1D) stellar atmosphere models and on the new generation of three-dimensional (3D) hydrodynamical models. We find that the non-LTE effects on the iron abundance derived from Fe {\sc i} lines are very important, amounting to ${\sim}0.9$ dex and to ${\sim}0.6$ dex in the 3D and 1D cases, respectively. On the other hand, we find that non-LTE and 3D effects have to be taken into account for a reliable determination of the iron abundance from weak Fe {\sc ii} lines, because the significant overexcitation of their upper levels in the granular regions tend to produce emission features. As a result such Fe {\sc ii} lines are weaker than in LTE and the abundance correction amounts to ${\sim}0.4$ dex for the 3D case. We derive also the oxygen-to-iron abundance ratio in the metal-poor star HD140283 by using the O {\sc i} triplet at 7772--5 \AA and the forbidden [O {\sc i}] line at 6300 \AA. Interestingly, when both non-LTE and 3D effects are taken into account there still remains significant discrepancies in the iron abundances derived from Fe {\sc i} and Fe {\sc ii} lines, as well as in the oxygen abundances inferred from the O {\sc i} and [O {\sc i}] lines. We conclude that the metalicity of this type of metal-poor stars could be significantly larger than previously thought, which may have far-reaching implications in stellar astrophysics.Comment: The Astrophysical Journal (in press). (35 pages, 5 figures and 4 tables

A Substantial Amount of Hidden Magnetic Energy in the Quiet Sun

Deciphering and understanding the small-scale magnetic activity of the quiet solar photosphere should help to solve many of the key problems of solar and stellar physics, such as the magnetic coupling to the outer atmosphere and the coronal heating. At present, we can see only ${\sim}1$ of the complex magnetism of the quiet Sun, which highlights the need to develop a reliable way to investigate the remaining 99%. Here we report three-dimensional radiative tranfer modelling of scattering polarization in atomic and molecular lines that indicates the presence of hidden, mixed-polarity fields on subresolution scales. Combining this modelling with recent observational data we find a ubiquitous tangled magnetic field with an average strength of ${\sim}130$ G, which is much stronger in the intergranular regions of solar surface convection than in the granular regions. So the average magnetic energy density in the quiet solar photosphere is at least two orders of magnitude greater than that derived from simplistic one-dimensional investigations, and sufficient to balance radiative energy losses from the solar chromosphere.Comment: 21 pages and 2 figures (letter published in Nature on July 15, 2004

BHLHE40 mediates cross-talk between pathogenic TH17 cells and myeloid cells during experimental autoimmune encephalomyelitis

TH17 cells are implicated in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). We previously reported that the transcription factor basic helix-loop-helix family member e40 (BHLHE40) marks cytokine-producing pathogenic TH cells during EAE, and that its expression in T cells is required for clinical disease. In this study, using dual reporter mice, we show BHLHE40 expression within TH1/17 and ex-TH17 cells following EAE induction. Il17a-Cre-mediated deletion of BHLHE40 in TH cells led to less severe EAE with reduced TH cell cytokine production. Characterization of the leukocytes in the CNS during EAE by single-cell RNA sequencing identified differences in the infiltrating myeloid cells when BHLHE40 was present or absent in TH17 cells. Our studies highlight the importance of BHLHE40 in promoting TH17 cell encephalitogenicity and instructing myeloid cell responses during active EAE

DYNAMICS OF BIOCHEMICAL INDICES OF BLOOD SERUM IN RABBITS UNDER THE INFLUENCE OF PHOTOTHERAPY AFTER LOCAL SKIN THERMAL BURN

The article presents data on the dynamics of some biochemical indices in blood serum of rabbits (total protein, alanine aminotransferase, ureal, creatinine, total cholesterol, glucose) during phototherapy of local skin thermal injury using "Bioprone", "Rikta", "Azor", OKN-11M, BOP-4 devices in 5-15 days after wounding. Obtained data testifies to the development of the response of an organism in the form of metabolic processes aimed at the maintenance of constant internal environment but expressed less that at vast burns. Course of phototherapy quite effectively but without distinct differentiation by the method of therapy has positive effect on the normalization of biochemical indices of blood serum

Oxygen abundances in planet-harbouring stars. Comparison of different abundance indicators

We present a detailed and uniform study of oxygen abundances in 155 solar type stars, 96 of which are planet hosts and 59 of which form part of a volume-limited comparison sample with no known planets. EW measurements were carried out for the [O I] 6300 \AA line and the O I triplet, and spectral synthesis was performed for several OH lines. NLTE corrections were calculated and applied to the LTE abundance results derived from the O I 7771-5 \AA\ triplet. Abundances from [O I], the O I triplet and near-UV OH were obtained in 103, 87 and 77 dwarfs, respectively. We present the first detailed and uniform comparison of these three oxygen indicators in a large sample of solar-type stars. There is good agreement between the [O/H] ratios from forbidden and OH lines, while the NLTE triplet shows a systematically lower abundance. We found that discrepancies between OH, [O I] and the O I triplet do not exceed 0.2 dex in most cases. We have studied abundance trends in planet host and comparison sample stars, and no obvious anomalies related to the presence of planets have been detected. All three indicators show that, on average, [O/Fe] decreases with [Fe/H] in the metallicity range -0.8<[Fe/H]<0.5. The planet host stars present an average oxygen overabundance of 0.1-0.2dex with respect to the comparison sample.Comment: 19 pages, 11 figures (low resolution), accepted for publication in A&

An overview of early investigational drugs for the treatment of human papilloma virus infection and associated dysplasia

Introduction: High-risk HPV (HR-HPV) related invasive cervical cancer (ICC) causes >270,000 deaths per annum world-wide with over 85% of these occurring in low-resource countries. Ablative and excisional treatment modalities are restricted for use with high-grade pre-cancerous cervical disease with HPV infection and low-grade dysplasia mostly managed by a watch-and-wait policy.Areas Covered: Various pharmacological approaches have been investigated as non-destructive alternatives for the treatment of HR-HPV infection and associated dysplasia. These are discussed dealing with efficacy, ease-of-use (physician or self-applied), systemic or locally applied, side-effects, cost and risks. The main focus is the perceived impact on current clinical practice of a self-applied, effective and safe pharmacological anti-HPV treatment.Expert opinion: Current prophylactic HPV vaccines are expensive, HPV type restricted and have little effect in already infected women. Therapeutic vaccines are under development but are also HPV type-restricted. At present, the developed nations use national cytology screening and surgical procedures to treat only women identified with HPV-related high-grade dysplastic disease. However, since HPV testing is rapidly replacing cytology as the test-of-choice, a suitable topically-applied and low-cost antiviral treatment could be an ideal solution for treatment of HPV infection per se with test-of-cure carried out by repeat HPV testing. Cytology would only then be necessary for women who remained HPV positive. Although of significant benefit in the developed countries, combining such a treatment with self-sampled HPV testing could revolutionise the management of this disease in the developing world which lack both the infrastructure and resources to establish national cytology screening programs

Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection

The cytokine IL-10 antagonizes pathways that contro

Редокс-реакции у Hydrocharis morsus-ranae L. в условиях техногенной нагрузки

Aquatic ecosystems are very sensitive to industrial impacts, and, therefore, it is increasingly important to study the mechanisms underlying the tolerance of aquatic organisms to water pollution. Heavy metals (HMs) are among the most common and toxic pollutants of aquatic ecosystems. They have a particularly strong effect on macrophytes, which are in close contact with the aquatic environment and can accumulate metals in considerable quantities. Hydrocharis morsus-ranae L. is a floating macrophyte (pleistophyte) with a high capacity for accumulation of HMs. The aim of the present study was to assess the effect of industrial pollution on the redox reactions in H. morsus-ranae and to identify the role of low molecular weight antioxidants in adaptation of this macrophyte to unfavorable conditions. A comparative analysis of the physiological and biochemical characteristics of H. morsus-ranae from two (reference and impacted) water bodies was carried out. The study revealed an increased level of lipid peroxidation products in the leaves of H. morsus-ranae under industrial impact, which indicates oxidative stress. Nevertheless, this floating plant demonstrated fairly high resistance to adverse conditions, due to the synthesis of non-enzymatic antioxidants such as proline and soluble protein thiols. Revealing the response of macrophytes to pollution of water bodies will help predict the state of aquatic ecosystems with an increase in anthropogenic pressure. © Siberian Federal University. All rights reserved.Acknowledgements. The reported study was partly funded by RFBR and the Government of the Sverdlovsk Region, project number 20–45–660014. The authors are grateful to the reviewer, Prof., D. Sc. Golovko T. K. (Institute of Biology of Komi Scientific Centre of the Ural Branch of RAS, Syktyvkar) for valuable comments that helped improve this paper and to Dr. Tripti (Ural Federal University, Ekaterinburg, Russia) for editing the English language

Oxygen in the Very Early Galaxy

Oxygen abundances in a sample of ultra-metal-poor subdwarfs have been derived from measurements of the oxygen triplet at 7771--5 A and OH lines in the near UV performed in high-resolution and high signal-to-noise spectra obtained with WHT/UES, KeckI/HIRES, and VLT/UVES. Our Fe abundances were derived in LTE and then corrected for NLTE effects following Thevenin and Idiart (1999). The new oxygen abundances confirm previous findings for a progressive linear rise in the oxygen-to-iron ratio with a slope -0.33+-0.02 from solar metallicity to [Fe/H] -3. A slightly higher slope would be obtained if the Fe NLTE corrections were not considered. Below [Fe/H]= -2.5 our stars show [O/Fe] ratios as high as ~ 1.17 (G64-12), which can be interpreted as evidence for oxygen overproduction in the very early epoch of the formation of the halo, possibly associated with supernova events with very massive progenitor stars. We show that the arguments against this linear trend given by Fulbright and Kraft (1999), based on the LTE Fe analysis of two metal-poor stars cannot be sustained when an NLTE analysis is performed. Using 1-D models our analysis of three oxygen indicators available for BD +23 3130 gives consistent abundances within 0.16 dex and average [O/Fe] ratio of 0.91.Comment: 45 pages, 11 figures, accepted for publication in The Astrophysical Journa

Eclipses observed by LYRA - a sensitive tool to test the models for the solar irradiance

We analyze the light curves of the recent solar eclipses measured by the Herzberg channel (200-220 nm) of the Large Yield RAdiometer (LYRA) onboard PROBA-2. The measurements allow us to accurately retrieve the center- to-limb variations (CLV) of the solar brightness. The formation height of the radiation depends on the observing angle so the examination of the CLV provide information about a broad range of heights in the solar atmosphere. We employ the 1D NLTE radiative transfer COde for Solar Irradiance (COSI) to model the measured light curves and corresponding CLV dependencies. The modeling is used to test and constrain the existing 1D models of the solar atmosphere, e.g. the temperature structure of the photosphere and the treatment of the pseudo- continuum opacities in the Herzberg continuum range. We show that COSI can accurately reproduce not only the irradiance from the entire solar disk, but also the measured CLV. It hence can be used as a reliable tool for modeling the variability of the spectral solar irradiance.Comment: 19 pages, 9 figures, Solar Physic