1,356 research outputs found
Species Abundance Patterns in Complex Evolutionary Dynamics
An analytic theory of species abundance patterns (SAPs) in biological
networks is presented. The theory is based on multispecies replicator dynamics
equivalent to the Lotka-Volterra equation, with diverse interspecies
interactions. Various SAPs observed in nature are derived from a single
parameter. The abundance distribution is formed like a widely observed
left-skewed lognormal distribution. As the model has a general form, the result
can be applied to similar patterns in other complex biological networks, e.g.
gene expression.Comment: 4 pages, 3 figures. Physical Review Letters, in pres
Search for Human-Specific Proteins Based on Availability Scores of Short Constituent Sequences: Identification of a WRWSH Protein in Human Testis
Little is known about protein sequences unique in humans. Here, we performed alignment-free sequence comparisons based on the availability (frequency bias) of short constituent amino acid (aa) sequences (SCSs) in proteins to search for human-specific proteins. Focusing on 5-aa SCSs (pentats), exhaustive comparisons of availability scores among the human proteome and other nine mammalian proteomes in the nonredundant (nr) database identified a candidate protein containing WRWSH, here called FAM75, as human-specific. Examination of various human genome sequences revealed that FAM75 had genomic DNA sequences for either WRWSH or WRWSR due to a single nucleotide polymorphism (SNP). FAM75 and its related protein FAM205A were found to be produced through alternative splicing. The FAM75 transcript was found only in humans, but the FAM205A transcript was also present in other mammals. In humans, both FAM75 and FAM205A were expressed specifically in testis at the mRNA level, and they were immunohistochemically located in cells in seminiferous ducts and in acrosomes in spermatids at the protein level, suggesting their possible function in sperm development and fertilization. This study highlights a practical application of SCS-based methods for protein searches and suggests possible contributions of SNP variants and alternative splicing of FAM75 to human evolution
Photoelectron Angular Distributions for Two-photon Ionization of Helium by Ultrashort Extreme Ultraviolet Free Electron Laser Pulses
Phase-shift differences and amplitude ratios of the outgoing and
continuum wave packets generated by two-photon ionization of helium atoms are
determined from the photoelectron angular distributions obtained using velocity
map imaging. Helium atoms are ionized with ultrashort extreme-ultraviolet
free-electron laser pulses with a photon energy of 20.3, 21.3, 23.0, and 24.3
eV, produced by the SPring-8 Compact SASE Source test accelerator. The measured
values of the phase-shift differences are distinct from scattering phase-shift
differences when the photon energy is tuned to an excited level or Rydberg
manifold. The difference stems from the competition between resonant and
non-resonant paths in two-photon ionization by ultrashort pulses. Since the
competition can be controlled in principle by the pulse shape, the present
results illustrate a new way to tailor the continuum wave packet.Comment: 5 pages, 1 table, 3 figure
HIV Types, Groups, Subtypes and Recombinant Forms: Errors in Replication, Selection Pressure and Quasispecies
HIV-1 is a chimpanzee virus which was transmitted to humans by several zoonotic events resulting in infection with HIV-1 groups M P, and in parallel transmission events from sooty mangabey monkey viruses leading to infections with HIV-2 groups A H. Both viruses have circulated in the human population for about 80 years. In the infected patient, HIV mutates, and by elimination of some of the viruses by the action of the immune system individual quasispecies are formed. Along with the selection of the fittest viruses, mutation and recombination after superinfection with HIV from different groups or subtypes have resulted in the diversity of their patterns of geographic distribution. Despite the high variability observed, some essential parts of the HIV genome are highly conserved. Viral diversity is further facilitated in some parts of the HIV genome by drug selection pressure and may also be enhanced by different genetic factors, including HLA in patients from different regions of the world. Viral and human genetic factors influence pathogenesis. Viral genetic factors are proteins such as Tat, Vif and Rev. Human genetic factors associated with a better clinical outcome are proteins such as APOBEC, langerin, tetherin and chemokine receptor 5 (CCR5) and HLA B27, B57, DRB1{*}1303, KIR and PARD3B. Copyright (C) 2012 S. Karger AG, Base
OGLE-2005-BLG-153: Microlensing Discovery and Characterization of A Very Low Mass Binary
The mass function and statistics of binaries provide important diagnostics of
the star formation process. Despite this importance, the mass function at low
masses remains poorly known due to observational difficulties caused by the
faintness of the objects. Here we report the microlensing discovery and
characterization of a binary lens composed of very low-mass stars just above
the hydrogen-burning limit. From the combined measurements of the Einstein
radius and microlens parallax, we measure the masses of the binary components
of and . This discovery
demonstrates that microlensing will provide a method to measure the mass
function of all Galactic populations of very low mass binaries that is
independent of the biases caused by the luminosity of the population.Comment: 6 pages, 3 figures, 1 tabl
OGLE-2005-BLG-071Lb, the Most Massive M-Dwarf Planetary Companion?
We combine all available information to constrain the nature of
OGLE-2005-BLG-071Lb, the second planet discovered by microlensing and the first
in a high-magnification event. These include photometric and astrometric
measurements from Hubble Space Telescope, as well as constraints from higher
order effects extracted from the ground-based light curve, such as microlens
parallax, planetary orbital motion and finite-source effects. Our primary
analysis leads to the conclusion that the host of Jovian planet
OGLE-2005-BLG-071Lb is an M dwarf in the foreground disk with mass M= 0.46 +/-
0.04 Msun, distance D_l = 3.3 +/- 0.4 kpc, and thick-disk kinematics v_LSR ~
103 km/s. From the best-fit model, the planet has mass M_p = 3.8 +/- 0.4 M_Jup,
lies at a projected separation r_perp = 3.6 +/- 0.2 AU from its host and so has
an equilibrium temperature of T ~ 55 K, i.e., similar to Neptune. A degenerate
model less favored by \Delta\chi^2 = 2.1 (or 2.2, depending on the sign of the
impact parameter) gives similar planetary mass M_p = 3.4 +/- 0.4 M_Jup with a
smaller projected separation, r_\perp = 2.1 +/- 0.1 AU, and higher equilibrium
temperature T ~ 71 K. These results from the primary analysis suggest that
OGLE-2005-BLG-071Lb is likely to be the most massive planet yet discovered that
is hosted by an M dwarf. However, the formation of such high-mass planetary
companions in the outer regions of M-dwarf planetary systems is predicted to be
unlikely within the core-accretion scenario. There are a number of caveats to
this primary analysis, which assumes (based on real but limited evidence) that
the unlensed light coincident with the source is actually due to the lens, that
is, the planetary host. However, these caveats could mostly be resolved by a
single astrometric measurement a few years after the event.Comment: 51 pages, 12 figures, 3 tables, Published in Ap
Temporal turnover and the maintenance of diversity in ecological assemblages
Temporal variation in species abundances occurs in all ecological communities. Here, we explore the role that this temporal turnover plays in maintaining assemblage diversity. We investigate a three-decade time series of estuarine fishes and show that the abundances of the individual species fluctuate asynchronously around their mean levels. We then use a time-series modelling approach to examine the consequences of different patterns of turnover, by asking how the correlation between the abundance of a species in a given year and its abundance in the previous year influences the structure of the overall assemblage. Classical diversity measures that ignore species identities reveal that the observed assemblage structure will persist under all but the most extreme conditions. However, metrics that track species identities indicate a narrower set of turnover scenarios under which the predicted assemblage resembles the natural one. Our study suggests that species diversity metrics are insensitive to change and that measures that track species ranks may provide better early warning that an assemblage is being perturbed. It also highlights the need to incorporate temporal turnover in investigations of assemblage structure and function
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