El nuevo régimen de la reutilización de las aguas depuradas: en especial las novedades en el nuevo Plan Hidrológico de la demarcación del Segura

La reutilización de las aguas depuradas constituye una práctica adecuada para incrementar la disponibilidad del recurso. Sin embargo, las implicaciones sanitarias que pudiera conllevar hacen necesario la instauración de un marco jurídico que otorgue seguridad a los diferentes sectores implicados. La incorporación de las aguas regeneradas a la gestión integral del dominio público hidráulico implica, a su vez, su consideración en los nuevos planes hidrológicos recientemente aprobados. En la Demarcación Hidrográfica del Segura, donde el recurso se encuentra sometido a una intensa presión por los actuales y potenciales usuarios, la reutilización puede representar un relevante recurso adicional

La custodia del territorio como instrumento complementario para la protección de los espacios naturales

La presente nota analiza la evolución normativa de la custodia del territorio como estrategia complementaria de protección de los espacios naturales caracterizada por las notas de participación y voluntariedad y que goza de una creciente vitalidad y posibilidades de futuro. En especial, se trata de subrayar la evolución de los mecanismos de protección que, si bien descansaban en el ejercicio unilateral de potestades administrativas, de modo creciente se orientan a estrategias acordadas con los sectores interesados y afectados, como modo de conseguir mayor apoyo social y colaboración de los particulares en la consecución de los fines de interés general, en este caso, la utilización racional de los recursos naturales, la garantía del derecho a disfrutar de un medio ambiente adecuado y el más cabal cumplimiento de los deberes de protección

Influence of deformation rate and degree of compression on textural parameters of potato and apple tissues in texture profile analysis

The influence of the degree of compression, at deformation rates of 50, 250 and 500 mm min-1, on the textural parameters in the texture profile analysis (TPA) of cylindrical samples of potato and apple tissues was examined. The tests were performed at up to eight different deformation levels ranging from 10% to 80%. The values of all the parameters measured in the samples of both tissues were influenced more by the degree of compression than by the deformation rate. Degrees of compression greater than 40% and 20% caused the rupture of potato and apple specimens, respectively. Regression models were fitted to express the variation of cohesiveness and chewiness with deformation rate and degree of compression. In apple and potato tissues, the degree of compression had a quadratic effect on the cohesiveness while the effect of the deformation rate was only linear. Cohesiveness was the most appropriate textural parameter for detecting effects of deformation rate and degree of compression in TPA tests of potato and apple tissues. Recoverable instantaneous springiness offers a high potential to differentiate the structural natures of different tissues. © Springer-Verlag 2002.Peer Reviewe

Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

The transcriptional regulator YAP orchestrates many cellular functions, including tissue homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to YAP activity, but the mechanisms controlling this regulation remain largely uncharacterized. We show that CAV1 positively modulates the YAP mechanoresponse to substrate stiffness through actin-cytoskeleton-dependent and Hippo-kinase-independent mechanisms. RHO activity is necessary, but not sufficient, for CAV1-dependent mechanoregulation of YAP activity. Systematic quantitative interactomic studies and image-based small interfering RNA (siRNA) screens provide evidence that this actin-dependent regulation is determined by YAP interaction with the 14-3-3 protein YWHAH. Constitutive YAP activation rescued phenotypes associated with CAV1 loss, including defective extracellular matrix (ECM) remodeling. CAV1-mediated control of YAP activity was validated in vivo in a model of pancreatitis-driven acinar-to-ductal metaplasia. We propose that this CAV1-YAP mechanotransduction system controls a significant share of cell programs linked to these two pivotal regulators, with potentially broad physiological and pathological implications. Moreno-Vicente et al. report that CAV1, a key component of PM mechanosensing caveolae, mediates adaptation to ECM rigidity by modulating YAP activity through the control of actin dynamics and phosphorylation-dependent interaction of YAP with the 14-3-3-domain protein YWHAH. Cav1-dependent YAP regulation drives two pathophysiological processes: ECM remodeling and pancreatic ADM. © 2018 The Author

Mapping the sustainable development goals into the EDINSOST sustainability map of bachelor engineering degrees

© 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes,creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.This Research to Practice Work in Progress paper presents the work conducted on the use of the Sustainability Map of Bachelor Engineering Degrees (a tool developed by the EDINSOST project) to analyze how Sustainable Development Goals (SDGs) are developed in each Degree. Over recent years, there has been a growth in the importance of working sustainability based on the SDGs. To identify which learning objective of each SDG corresponds to each learning outcome of the EDINSOST Sustainability Map, a correspondence matrix has been defined. The matrix contains the learning outcomes of the EDINSOST Sustainability Map in its rows, and the 17 SDGs in the columns. The cells of the matrix contain the learning objectives of the SDGs that correspond to each learning outcome of the EDINSOST Sustainability Map. This work in progress presents the first results of the process of mapping the SDGs into the EDINSOST Sustainability Map of Engineering Bachelor Degrees. Early results show that some of the 169 learning objectives are not applicable to Engineering Degrees. Likewise, we have seen that learning objectives have been defined more for policy makers than for engineers, and therefore adaptation is not an easy task. However, the work done has helped us to verify that the EDINSOST Sustainability Map can help in the introduction of the SDGs into the curriculum.Peer ReviewedPostprint (author's final draft

A learning tool to develop sustainable projects

This paper presents a tool developed to help engineers to design and develop sustainable projects. The tool has been designed to introduce and evaluate the sustainability of engineering projects in general, but here we show its application to assess the final project of an engineering degree. This tool is a guide for students to introduce and estimate the sustainability of their projects, but it also helps teachers to assess them. The tool is based on the Socratic Methodology and consists of a matrix where each cell contains several questions that students must consider during the project development and which they must answer in their project report. A positive or negative mark is assigned to every cell, and the sum of all marks states the project sustainability. However, the result is not as simplistic as a final number, but a descriptive sustainability analysis where questions are answered and every mark justified. A pilot test with some students has obtained good results, but the first Final Degree Project using this methodology will be read in July 2016.Peer ReviewedPostprint (author's final draft

On balancedness and D-Completeness of the space of Semi-lipschitz functions

Let (X, d) be a quasi-metric space and (Y, q) be a quasi-normed linear space. We show that the normed cone of semi-Lipschitz functions from (X, d) to (Y, q) that vanish at a point x0 E X, is balanced. Moreover, it is complete in the sense of D. Doitchinov whenever (Y, q) is a biBanach spac

A methodology to introduce sustainability into the Final Year Project to foster sustainable engineering projects

The introduction of sustainability skills into higher education curricula is a natural effect of the increasing importance of sustainability in our daily lives. Topics like green computing, sustainable design or environmental engineering have become part of the knowledge required by today’s engineers. Furthermore, we strongly believe that the introduction of this skill will eventually enable future engineers to develop sustainable products, services and projects. The Final Year Project is the last academic stage facing students and a step towards their future professional engineering projects. As such, it constitutes a rehearsal for their professional future and an ideal opportunity for reflecting on whether their Final Year Project is sustainable or not, and to what extent. It also provides a good tool for reviewing the lessons learned about sustainability during the degree course and for applying them in a holistic and integrated way. In this paper, we present a guide that allows both students and advisors to think carefully about the sustainability of engineering projects, in particular the Final Year Project.Postprint (author’s final draft

La intervención escolar en los trastornos del espectro autista

[Resumen] La integración social y escolar de los niños con trastorno del espectro autista es un hecho consumado desde los últimos años. Sin embargo, su práctica debe considerar una serie de adaptaciones y ajustes. Las limita- ciones que manifiestan estos niños son muy variadas y heterogéneas, lo que en la práctica escolar debe traducirse por una actuación educativa que de respuesta a sus necesidades y habilidades. El objetivo del presente artícu- lo es revisar algunas cuestiones centrales para la intervención psicoeducativa de los niños con trastorno de espectro autista, las modalidades de escolarización y las adapta- ciones tanto curriculares como sociales. Se proponen algunas mejoras para la puesta en marcha efectiva de las diferentes medidas educativas a adoptar.[Abstract] The social and school integration of chil- dren with autistic spectrum disorders is a fait accompli in recent years. However, its practi- ce must consider a series of adaptations and adjustments. These children show a variety of heterogeneous limitations, what in the school practice must be translated into an educative performance that responds to their needs and abilities. The goal of this article is to revise some vital questions for the psychoeducative intervention in children with autistic spectrum disorders, for the different schooling systems and for the curricular or social adaptations. Improvements are proposed in order to carry out an effective launch of the different educa- tive measures that must be taken