Presence of fibroids in the absence of uterus- Mayer-Rokitansky-Küster-Hauser syndrome with fibroids: a case report

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is rare congenital anomaly with complete absence of uterus and upper part of vagina. Fibroids are one of the most common benign tumours arising in women. Fibroids arising from Mullerian remnants are very rare. These fibroids often pose difficulty in diagnosis and management. Here, we report a rare case of fibroids arising from Mullerian remnants in MRKH syndrome and the treatment provided for the patient

Effects of monthly feedback of VFA measured by dual BIA method in Japanese patients with obesity: a randomized controlled study

Objective: To investigate the effects of monthly feedback of changes in visceral fat area (VFA) as measured by dual bioelectrical impedance analysis method and the importance of VFA in individuals with obesity. Methods: Thirty‐eight Japanese patients with obesity underwent VFA measurements. The feedback group was given feedback on VFA measurements each month for 4 months. The control group underwent VFA measurements at the beginning and end of the study but was not informed of the results. All the study participants completed eating behaviour and weight efficacy lifestyle questionnaires. Results: Mean age was 53.9 (14.3) years; mean body mass index was 30.6 (4.3) kg m⁻². At the 4‐month follow‐up, there was no significant difference in VFA reduction between the control and feedback groups (−4.4% vs. −3.0%; 95% CI, −3.8 to 5.5). In post‐hoc analysis using the overall group irrespective of allocation, changes of eating style were significantly associated with a reduction in VFA at 4 months (p = 0.034). Conclusions: Monthly feedback on changes in VFA does not reduce VFA. More frequent feedback may be required. In post‐hoc analysis, changes of eating style were associated with a reduction in VFA

The Role of Applied Behaviour Analysing in Zoo Management System for Animals

This study examines the use of Applied Behaviour Analysis (ABA) in animal management systems in zoos with an emphasis on how well it enhances animal wellbeing. The goals of the study were comparing ABA-based approaches to conventional zoo management techniques and evaluating the effect of ABA on stress reduction in captive chimpanzees. Over the course of a year, information was gathered from a chosen group of chimpanzees, including baseline and post-ABA stress levels. Following the use of ABA techniques, the data from Table 1 show a consistent trend among the chimpanzees, suggesting a considerable reduction in stress levels. Strong evidence for the effectiveness of ABA in lowering stress levels in the chimpanzees was given by statistical analysis of the data (Table 2). With a high t-statistic of 8.25, the mean baseline stress level of 7.7 substantially decreased to 3.5 post-ABA treatments (p 0.05), emphasizing the significance of this reduction. With regard to reducing stress, Objective 2 compared ABA-Based and Traditional groups. Compared to the Traditional group, the ABA-Based method had a reduced baseline stress level, according to the findings in Table 3. The ABA-Based group showed a significant reduction in stress levels following ABA sessions, while the Traditional group also showed a reduction in stress levels, albeit to a lesser extent. Both strategies significantly reduced stress, according to statistical analysis (Table 4), with the ABA-Based strategy having a greater degree of statistical significance (p 0.05). This study concludes by offering empirical proof that Applied Behaviour Analysis is a useful method for enhancing animal wellbeing in the context of zoo management. The findings imply that when compared to conventional management techniques, ABA therapies can significantly lower stress levels in caged animals

Low-cost, Multispectral Imaging Mini-microscope for Longitudinal Oximetry in Small Animals

No abstract available

Targeting the IGF-axis potentiates immunotherapy for pancreatic ductal adenocarcinoma liver metastases by altering the immunosuppressive microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy, resistant to chemotherapy and associated with high incidence of liver metastases and poor prognosis. Using murine models of aggressive PDAC, we show here that in mice bearing hepatic metastases, treatment with the IGF-Trap, an inhibitor of type I insulin-like growth factor receptor (IGF-IR) signaling, profoundly altered the local, immunosuppressive tumor microenvironment in the liver, curtailing the recruitment of myeloid-derived suppressor cells, reversing innate immune cell polarization and inhibiting metastatic expansion. Significantly, we found that immunotherapy with anti-PD-1 antibodies also reduced the growth of experimental PDAC liver metastases, and this effect was enhanced when combined with IGF-Trap treatment, resulting in further potentiation of a T-cell response. Our results show that a combinatorial immunotherapy based on dual targeting of the prometastatic immune microenvironment of the liver via IGF blockade, on one hand, and reversing T-cell exhaustion on the other, can provide a significant therapeutic benefit in the management of PDAC metastases.Fil: Hashimoto, Masakazu. McGill University; CanadáFil: Konda, John David. McGill University; CanadáFil: Perrino, Stephanie. McGill University; CanadáFil: Fernández, María Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina. McGill University; CanadáFil: Lowy, Andrew M.. Moores Cancer Centre; Estados UnidosFil: Brodt, Pnina. McGill University; Canad

DESIGN OF HIGH SPEED LESS AREA RADIX 2 AND RADIX 4 BOOTH SIGNED MULTIPLIER

This study presents the form and performance of restricted configurable Booth encoding multiplier for both witnessed and unregistered 32-bit numbers repeating & the hovering tend multiplication. Multiplication action is a usually used in many mathematical and beacon processing applications. An area valuable performance of a pumped-up configurable Radix-4 Booth multiplier with 3:2 compressors is devised & implemented on FPGA. Thus it provides amenable computation strength and a correct crop fidelity and high boost, dab area drinking. The form also dynamically disables the switching surgery of the not forceful knowledge ranges. Thus the inactive circuits perchance completely deactivated, with contracting prestige decrease and accelerating the further of effort. Thus the scheduled device of multiplier outperforms the typical multiplier in terms of area and further efficiencies. The scheduled produce has been implemented on FPGA Spartan 6 XC6SLX9 principle providing with a correlation of basics utilized and implementation boosts

Hospital Organization and Importance of an Interventional Radiology Inpatient Admitting Service:Italian Single-Center 3-year Experience

In June 2005 a Complex Operating Unit of Interventional Radiology (COUIR), consisting of an outpatient visit service, an inpatient admitting service with four beds, and a day-hospital service with four beds was installed at our department. Between June 2005 and May 2008, 1772 and 861 well-screened elective patients were admitted to the inpatient ward of the COUIR and to the Internal Medicine Unit (IMU) or Surgery Unit (SU) of our hospital, respectively, and treated with IR procedures. For elective patients admitted to the COUIR’s inpatient ward, hospital stays were significantly shorter and differences between reimbursements and costs were significantly higher for almost all IR procedures compared to those for patients admitted to the IMU and SU (Student’s t-test for unpaired data, p\0.05). The results of the 3-year activity show that the activation of a COUIR with an inpatient admitting service, and the better organization of the patient pathway that came with it, evidenced more efficient use of resources, with the possibility for the hospital to save money and obtain positive margins (differences between reimbursements and costs). During 3 years of activity, the inpatient admitting service of our COUIR yielded a positive difference between reimbursements and effective costs of €1,009,095.35. The creation of an inpatient IR service and the admission of well-screened elective patients allowed short hospitalization times, reduction of waiting lists, and a positive economic outcome. Keywords Inpatients Hospitalization Costs Reimbursement

Validation of QTL mapping and transcriptome profiling for identification of candidate genes associated with nitrogen stress tolerance in sorghum

Background: Quantitative trait loci (QTLs) detected in one mapping population may not be detected in other mapping populations at all the time. Therefore, before being used for marker assisted breeding, QTLs need to be validated in different environments and/or genetic backgrounds to rule out statistical anomalies. In this regard, we mapped the QTLs controlling various agronomic traits in a recombinant inbred line (RIL) population in response to Nitrogen (N) stress and validated these with the reported QTLs in our earlier study to find the stable and consistent QTLs across populations. Also, with Illumina RNA-sequencing we checked the differential expression of gene (DEG) transcripts between parents and pools of RILs with high and low nitrogen use efficiency (NUE) and overlaid these DEGs on to the common validated QTLs to find candidate genes associated with N-stress tolerance in sorghum. Results: An F7 RIL population derived from a cross between CK60 (N-stress sensitive) and San Chi San (N-stress tolerant) inbred sorghum lines was used to map QTLs for 11 agronomic traits tested under different N-levels. Composite interval mapping analysis detected a total of 32 QTLs for 11 agronomic traits. Validation of these QTLs revealed that of the detected, nine QTLs from this population were consistent with the reported QTLs in earlier study using CK60/China17 RIL population. The validated QTLs were located on chromosomes 1, 6, 7, 8, and 9. In addition, root transcriptomic profiling detected 55 and 20 differentially expressed gene (DEG) transcripts between parents and pools of RILs with high and low NUE respectively. Also, overlay of these DEG transcripts on to the validated QTLs found candidate genes transcripts for NUE and also showed the expected differential expression. For example, DEG transcripts encoding Lysine histidine transporter 1 (LHT1) had abundant expression in San Chi San and the tolerant RIL pool, whereas DEG transcripts encoding seed storage albumin, transcription factor IIIC (TFIIIC) and dwarfing gene (DW2) encoding multidrug resistance-associated protein-9 homolog showed abundant expression in CK60 parent, similar to earlier study. Conclusions: The validated QTLs among different mapping populations would be the most reliable and stable QTLs across germplasm. The DEG transcripts found in the validated QTL regions will serve as future candidate genes for enhancing NUE in sorghum using molecular approaches