Electrochemical processes and systems: application for tutors

The features of redox reactions and the principles of their balancing according to the medium composition are considered. The basic representations about electrochemical processes and systems are outlined. The reactions and principles of chemical sources of electric energy and electrolysis systems functioning are analyzed. A general idea is given about the chemical properties of metals, corrosion resistance in environments of various aggressiveness, and the protection principles are given. Multivariate tasks and exercises for students, and PhD student’s classroom and independent work are offered. For teachers, PhD students and students of universities of specialties "Chemical technologies and engineering", "Biotechnologies and bioengineering", "Oil and gas engineering and technologies".Розглянуто особливості окисно-відновних реакцій і принципи їх балансування залежно від складу середовища. Викладено фундаментальні уявлення про електрохімічні процеси і системи. Проаналізовано перебіг реакцій і принципи функціонування хімічних джерел електричної енергії та систем електролізу. Узагальнено уявлення щодо хімічних властивостей металів, корозійної стійкості у середовищах різної агресивності та наведено принципи організації захисту від руйнування. Запропоновано багатоваріантні завдання та вправи для аудиторної та самостійної роботи студентів і аспірантів. Розраховано на викладачів, аспірантів і студентів вищих навчальних закладів спеціальностей "Хімічні технології та інженерія”, "Біотехнології та біоінженерія", "Нафтогазова інженерія та технології"

АНАЛІЗ НЕСПРИЯТЛИВИХ ПОДІЙ ПІСЛЯ ІМУНІЗАЦІЇ ВАКЦИНАМИ ПРОТИ SARS CoV-2

Although the WHO-recommended coronavirus vaccines are safe and effective, vaccines provide new information to healthcare professionals about the extent and nature of adverse reactions to these drugs. The aim of the study is supplementing the available data on adverse reactions of vaccines on the example of the experience of vaccination of the teaching staff of the Cherkasy Medical Academy with vaccines COVISHIELD and COMIRNATY. Information for this study was collected retrospectively through a survey of 72 employees of the Cherkasy Medical Academy who were vaccinated with the COVISHIELD vaccine (first dose); 67 workers vaccinated with AstraZeneca (second dose); 54 workers who were vaccinated with COMIRNATY vaccine (first dose); 52 people vaccinated with this vaccine (second dose). The study confirmed that among the local side effects, the most common were pain at the injection site, among the systemic - fever, weakness, fatigue and drowsiness, headache, muscle pain, chills. Most of the side effects were most pronounced in young people, more often in women than in men.Although the WHO-recommended coronavirus vaccines are safe and effective, vaccines provide new information to healthcare professionals about the extent and nature of adverse reactions to these drugs. The aim of the study is supplementing the available data on adverse reactions of vaccines on the example of the experience of vaccination of the teaching staff of the Cherkasy Medical Academy with vaccines COVISHIELD and COMIRNATY. Information for this study was collected retrospectively through a survey of 72 employees of the Cherkasy Medical Academy who were vaccinated with the COVISHIELD vaccine (first dose); 67 workers vaccinated with AstraZeneca (second dose); 54 workers who were vaccinated with COMIRNATY vaccine (first dose); 52 people vaccinated with this vaccine (second dose). The study confirmed that among the local side effects, the most common were pain at the injection site, among the systemic - fever, weakness, fatigue and drowsiness, headache, muscle pain, chills. Most of the side effects were most pronounced in young people, more often in women than in men

Increase housing provision of citizens as a priority direction of social and economic development of the region

Set out the results of the study provide citizens with housing as a priority direction of social and economic development of the market; showed the causes of low housing provision of citizens of the Belgorod region, made conclusions and identified measures to increase housing provision in the cities of RussiayesBelgorod State National Research Universit

Some Remarks on Combining Forms in English-Japanese Dictionaries

© 2016, Pleiades Publishing, Inc.Previously unknown isononylcalix[8]arene was synthesized from commercially available isononylphenol. The properties of the product (solubility, extraction ability, tendency to aggregation) were compared with those of the known tert-butylcalix[8]arene. The extraction of 137Cs, 99mTc, and 241Am from alkaline carbonate solutions with solutions of p-alkylcalix[8]arenes (alkyl = tert-butyl, isononyl) in tetrachloroethylene was studied. The dependence of the distribution ratios on pH of the aqueous phase in the interval from 11 to 13.9 and on the nature of functional groups in the calixarene core was determined. The composition of extractable solvates of cesium and americium with calix[8]arenes was found. Calix[8]arenes extract cesium from alkaline solutions more efficiently than p-tert-butylphenol, their nonmacrocyclic analog, does. tert-Butylcalix[8]arene exhibits the highest performance, which may be due to formation of aggregates 5.7 ± 0.8 nm in diameter in the organic phase at pH 13.5 of the aqueous phase. The isononyl derivative exists in the monomeric form (particle diameter 1.9 ± 0.5 nm)

Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism

In 178 patients with different clinical forms of pulmonary tuberculosis carried out pharmacogenetic testing to determine gene polymorphism glutathione S-transferase system (GSTM1, GSTT1). Estimated the severity and duration of clinical manifestations of the syndrome of intoxication, depending on the gene polymorphism of glutathione S-transferase system (GSTM1, GSTT1). It was found that the combination of “zero” to develop genotypes GSTM1 and GSTT1 enzyme is a predictor of the severity and duration of symptoms of intoxication persisting

Stat1 nuclear translocation by nucleolin upon monocyte differentiation

BACKGROUND: Members of the signal transducer and activator of transcription (Stat) family of transcription factors traverse the nuclear membrane through a specialized structure, called the nuclear pore complex (NPC), which represents a selective filter for the import of proteins. Karyophilic molecules can bind directly to a subset of proteins of the NPC, collectively called nucleoporins. Alternatively, the transport is mediated via a carrier molecule belonging to the importin/karyopherin superfamily, which transmits the import into the nucleus through the NPC. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we provide evidence for an alternative Stat1 nuclear import mechanism, which is mediated by the shuttle protein nucleolin. We observed Stat1-nucleolin association, nuclear translocation and specific binding to the regulatory DNA element GAS. Using expression of nucleolin transgenes, we found that the nuclear localization signal (NLS) of nucleolin is responsible for Stat1 nuclear translocation. We show that this mechanism is utilized upon differentiation of myeloid cells and is specific for the differentiation step from monocytes to macrophages. CONCLUSIONS/SIGNIFICANCE: Our data add the nucleolin-Stat1 complex as a novel functional partner for the cell differentiation program, which is uniquely poised to regulate the transcription machinery via Stat1 and nuclear metabolism via nucleolin

A molecular assembly system for presentation of antigens on the surface of HBc virus-like particles

AbstractHepatitis B virus-like particles, icosahedral structures formed by multiple core protein dimers, are promising immune-enhancing vaccine carriers for foreign antigens. Insertions into the surface-exposed immunodominant loop are especially immunogenic. However, the need to conserve the particulate structure to ensure high immunogenicity imposes restraints on the nature of the heterologous sequence that can be inserted. We propose a new approach to constructing HBc particles linked to the target epitopes that relies on non-covalent interactions between the epitope and pre-assembled unmodified HBc particles. Interaction was enabled by fusion of the epitope to the GSLLGRMKGA peptide, binding to the spike tips. This peptide may be used as a “binding tag” allowing in vitro construction of HBc particles carrying the target peptide. Such virus-like particles carrying multiple copies of the extracellular domain of the M2 protein of different influenza strains appeared to be highly immunogenic and protected immunised mice against a lethal influenza challenge

ABOUT NON-TRADITIONAL FEED ADDITIVES INFLUENCE ON SAFETY OF THE YAKUT BREED HORSES LIVE WEIGHT

Horse breeding is one of the rapidly developing branches of animal husbandry in Yakutia. Horses of the Yakut breed are only type of farm animals that are kept year-round in harsh conditions of the sharply continental climate of Yakutia. In winter, animals experience a significant lack of nutrients and minerals. This is due to fact that basic diet consists of natural feed winter pasture and hay. Therefore, the goal was to study the effect of complex feed additives from local natural raw materials on the change in live weight and biochemical composition of the blood of animals. This study used standard animal research methods. The use of non-traditional feed additives in feeding of horses contributed to an increase in the supply of nutrients and minerals to the rations. Improving feeding conditions affected the live weight of horses (live weight loss was 5.75 % и 5.45 %). The change caused by inclusion of non-traditional feed additives in the diets of horses had a positive effect on the morphological and biochemical composition of the blood animals. In horses from the experimental groups, an increase was found in the blood in total protein by 0.50 % and 0.30 %, albumin by 0.36 and 0.20 %, globulin by 0.13 and 0.10 %, hemoglobin by 2.91 and 1.33 %, calcium by 3.56 and 1.29%, phosphorus by 5.71 and 1.90 %. Thus, use of experimental non-traditional feed additives in feeding horses in winter contributes to the best preservation of live weight. This is due to the improvement of mineral and vitamin nutrition in a difficult period of deficiency of macro- and microelements, vitamins in the diets of horses. This improves metabolism, which is reflected in the morphological and biochemical composition of blood of horses