Promoting deep learning through design - discussion, student activity and assessment

There is widespread evidence that Australia is currently facing falling student participation rates in science and mathematics subjects at secondary school and university undergraduate levels. The future implications of this science-deficit are widely acknowledged. Unfortunately, science teaching itself is also widely seen as being dull, too content-heavy, delivered to mass-audiences and assessed in ways promoting surface approaches to learning. To address these issues, and issues relating to the apparent lack of challenge for very able students in their first year at university, The University of Queensland developed the Advanced Study Program in Science (ASPinS). This initiative offers an enhanced learning experience to a select group of high-achieving students in addition to their existing undergraduate study in a Science-related degree program. ASPinS offers these students the opportunity to interact with leading research scientists, broaden their understanding of important scientific issues, experience new interactive learning opportunities, undertake research projects and obtain an authentic insight into science as a career. This presentation, however, will only focus on the unique first year course offered within the 3 year ASPinS experience – BIOL1017 “Perspectives in Science”. In this course students are encouraged to think about important current scientific issues from different perspectives – both scientific and non-scientific. Panels of expert scientists use their knowledge and experience to present real scientific issues for students to examine and discuss. These panel discussions cover a spectrum of medical, environmental and social issues, covering different viewpoints and possible solutions. Combining this effective panel model with an array of student-led activities provides an ideal environment for learning. Students are made to apply their new knowledge, discuss issues and construct thoughts, opinions and products – depending on the specifically designed activities. Relevant assessment tasks include group-writing activities and oral presentations which enable students to demonstrate their learning through authentic contexts that are carefully designed to influence the way students learn. Authentic assessment tasks enable students to see a purpose for the product (assessment) they are producing while at the same time enabling them to synthesise the various scientific ‘facts’ and issues they have been discussing. This level of assessment activity, by its nature, encourages higher-order learning. Student evaluations have consistently confirmed that the key to the success of each Module within the course lies in the breadth of speakers selected to represent the different angles associated with the topic under discussion and the related activities and assessment tasks. The findings indicate that students value the opportunity to explore the multi-disciplinary nature of science-related issues and to actually discuss the issues. The “Perspectives in Science” course is a model for the success of combining teaching and learning theory and scholarship, to a particular set of objectives, to create a highly effective learning environment and a meaningful student experience

Fluctuations of the Lyapunov exponent in 2D disordered systems

We report a numerical investigation of the fluctuations of the Lyapunov exponent of a two dimensional non-interacting disordered system. While the ratio of the mean to the variance of the Lyapunov exponent is not constant, as it is in one dimension, its variation is consistent with the single parameter scaling hypothesis

Scalloped margin domes: What are the processes responsible and how do they operate?

Studies of scalloped margin domes (SMD) indicate the scallops are the result of slope failure. SMD's have similar but smaller average diameters (26.5 km) to unmodified domes (29.8 km), and the majority plot at altitudes ranging from 0.5-4.7 km, relative to the mean planetary diameter. A range of morphological types exist from those least modified to those that show heavy modification. Of the 200 SMD's examined, 33 have clearly discernible debris aprons. Examination and comparison of debris aprons with mass movement features on the Moon, Mars, and in sub-aerial and submarine environments on Earth using H/L against area (km(sup 2)), suggests there are three main types of failure; debris avalanche, slumps, and debris flow. The five examples representing the morphological range within the SMD's, show the different modified forms and the different types of slope failures that have occurred

The statistical mechanics of a polygenic characterunder stabilizing selection, mutation and drift

By exploiting an analogy between population genetics and statistical mechanics, we study the evolution of a polygenic trait under stabilizing selection, mutation, and genetic drift. This requires us to track only four macroscopic variables, instead of the distribution of all the allele frequencies that influence the trait. These macroscopic variables are the expectations of: the trait mean and its square, the genetic variance, and of a measure of heterozygosity, and are derived from a generating function that is in turn derived by maximizing an entropy measure. These four macroscopics are enough to accurately describe the dynamics of the trait mean and of its genetic variance (and in principle of any other quantity). Unlike previous approaches that were based on an infinite series of moments or cumulants, which had to be truncated arbitrarily, our calculations provide a well-defined approximation procedure. We apply the framework to abrupt and gradual changes in the optimum, as well as to changes in the strength of stabilizing selection. Our approximations are surprisingly accurate, even for systems with as few as 5 loci. We find that when the effects of drift are included, the expected genetic variance is hardly altered by directional selection, even though it fluctuates in any particular instance. We also find hysteresis, showing that even after averaging over the microscopic variables, the macroscopic trajectories retain a memory of the underlying genetic states.Comment: 35 pages, 8 figure

How organizational cognitive neuroscience can deepen understanding of managerial decision-making:a review of the recent literature and future directions

There is growing interest in exploring the potential links between human biology and management and organization studies, which is bringing greater attention to bear on the place of mental processes in explaining human behaviour and effectiveness. The authors define this new field as organizational cognitive neuroscience (OCN), which is in the exploratory phase of its emergence and diffusion. It is clear that there are methodological debates and issues associated with OCN research, and the aim of this paper is to illuminate these concerns, and provide a roadmap for rigorous and relevant future work in the area. To this end, the current reach of OCN is investigated by the systematic review methodology, revealing three clusters of activity, covering the fields of economics, marketing and organizational behaviour. Among these clusters, organizational behaviour seems to be an outlier, owing to its far greater variety of empirical work, which the authors argue is largely a result of the plurality of research methods that have taken root within this field. Nevertheless, all three clusters contribute to a greater understanding of the biological mechanisms that mediate choice and decision-making. The paper concludes that OCN research has already provided important insights regarding the boundaries surrounding human freedom to act in various domains and, in turn, self-determination to influence the workplace. However, there is much to be done, and emerging research of significant interest is highlighted

Automated Analysis of Cryptococcal Macrophage Parasitism Using GFP-Tagged Cryptococci

The human fungal pathogens Cryptococcus neoformans and C. gattii cause life-threatening infections of the central nervous system. One of the major characteristics of cryptococcal disease is the ability of the pathogen to parasitise upon phagocytic immune effector cells, a phenomenon that correlates strongly with virulence in rodent models of infection. Despite the importance of phagocyte/Cryptococcus interactions to disease progression, current methods for assaying virulence in the acrophage system are both time consuming and low throughput. Here, we introduce the first stable and fully characterised GFP–expressing derivatives of two widely used cryptococcal strains: C. neoformans serotype A type strain H99 and C. gattii serotype B type strain R265. Both strains show unaltered responses to environmental and host stress conditions and no deficiency in virulence in the macrophage model system. In addition, we report the development of a method to effectively and rapidly investigate macrophage parasitism by flow cytometry, a technique that preserves the accuracy of current approaches but offers a four-fold improvement in speed

Negotiations of minority ethnic rugby league players in the Cathar country of France

This article is based on new empirical, qualitative research with minority ethnic rugby league players in the southwest of France. Drawing on similar research on rugby league in the north and the south of England, the article examines how rugby league, traditionally viewed as a white, working-class male game (Collins, 2006; Denham, 2004; Spracklen, 1995, 2001) has had to re-imagine its symbolic boundaries as they are constituted globally and locally to accommodate the needs of players from minority ethnic backgrounds. In particular, the article examines the sense in which experiences of minority ethnic rugby league players in France compare with those of their counterparts in England (Spracklen, 2001, 2007), how rugby league is used in France to construct identity, and in what sense the norms associated with the imaginary community of rugby league are replicated or challenged by the involvement of minority ethnic rugby league players in France. Questions about what it means to be (provincial, national) French (Kumar, 2006) are posed, questions that relate to the role of sport in the construction of Frenchness, and in particular the role of rugby league (and union). © Copyright ISSA and SAGE Publications

Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves.

Acid sensing in the gastrointestinal tract is required for gut homeostasis and the detection of tissue acidosis caused by ischaemia, inflammation and infection. In the colorectum, activation of colonic afferents by low pH contributes to visceral hypersensitivity and abdominal pain in human disease including during inflammatory bowel disease. The naked mole-rat (Heterocephalus glaber) shows no pain-related behaviour to subcutaneous acid injection and cutaneous afferents are insensitive to acid, an adaptation thought to be a consequence of the subterranean, likely hypercapnic, environment in which it lives. As such we sought to investigate naked mole-rat interoception within the gastrointestinal tract and how this differed from the mouse (Mus Musculus). Here, we show the presence of calcitonin gene-related peptide expressing extrinsic nerve fibres innervating both mesenteric blood vessels and the myenteric plexi of the smooth muscle layers of the naked mole-rat colorectum. Using ex vivo colonic-nerve electrophysiological recordings, we show differential sensitivity of naked mole-rat, compared to mouse, colonic afferents to acid and the prototypic inflammatory mediator bradykinin, but not direct mechanical stimuli. In naked mole-rat, but not mouse, we observed mechanical hypersensitivity to acid, whilst both species sensitised to bradykinin. Collectively, these findings suggest that naked mole-rat colonic afferents are capable of detecting acidic stimuli; however, their intracellular coupling to downstream molecular effectors of neuronal excitability and mechanotransduction likely differs between species.The authors declare no competing financial interests. This work was supported by Rosetrees Postdoctoral Grant (A1296; JRFH and EStJS), BBSRC grant (BB/R006210/1; JRFH and EStJS), Versus Arthritis Pain Challenge Grant (RG21973; GC and EStJS), AstraZeneca PhD studentshipt (KHB), EMBO Long-Term Fellowship (ALTF1565-2015; ZH) and University of Cambridge Vice Chancellor’s Award (TST)

Using evolutionary demography to link life history theory, quantitative genetics and population ecology

1. There is a growing number of empirical reports of environmental change simultaneously influencing population dynamics, life history and quantitative characters. We do not have a well-developed understanding of links between the dynamics of these quantities