Unexpected series of regular frequency spacing of delta Scuti stars in the non-asymptotic regime -- I. The methodology

A sequence search method was developed to search regular frequency spacing in delta Scuti stars by visual inspection and algorithmic search. We searched for sequences of quasi-equally spaced frequencies, containing at least four members per sequence, in 90 delta Scuti stars observed by CoRoT. We found an unexpectedly large number of independent series of regular frequency spacing in 77 delta Scuti stars (from 1 to 8 sequences) in the non-asymptotic regime. We introduce the sequence search method presenting the sequences and echelle diagram of CoRoT 102675756 and the structure of the algorithmic search. Four sequences (echelle ridges) were found in the 5-21 d^{-1} region, where the pairs of the sequences are shifted (between 0.5-0.59 d^{-1}) by twice the value of the estimated rotational splitting frequency (0.269 d^{-1}). The general conclusions for the whole sample are also presented in this paper. The statistics of the spacings derived by the sequence search method, by FT and that of the shifts are also compared. In many stars, more than one almost equally valid spacing appeared. The model frequencies of FG Vir and their rotationally split components were used to reveal a possible explanation that one spacing is the large separation, while the other is a sum of the large separation and the rotational frequency. In CoRoT 102675756, the two spacings (2.249 and 1.977 d^{-1}) agree better with the sum of a possible 1.710 d^{-1} large separation and two or one times, respectively, the value of the rotational frequency.Comment: 12 pages, 10 figures, accepted for publication in Ap

Unexpected series of regular frequency spacing of delta Scuti stars in the non-asymptotic regime -- II. Sample -- echelle diagrams and rotation

A sequence search method was developed for searching for regular frequency spacing in delta Scuti stars by visual inspection and algorithmic search. The sample contains 90 delta Scuti stars observed by CoRoT. An example is given to represent the visual inspection. The algorithm (SSA) is described in detail. The data treatment of the CoRoT light curves, the criteria for frequency filtering and the spacings derived by two methods (three approaches: VI, SSA and FT) are given for each target. Echelle diagrams are presented for 77 targets, for which at least one sequence of regular spacing was identified. Comparing the spacing and the shifts between pairs of echelle ridges revealed that at least one pair of echelle ridges is shifted to midway between the spacing for 22 stars. The estimated rotational frequencies compared to the shifts revealed rotationally split doublets, triplets and multiplets not only for single frequencies, but for the complete echelle ridges in 31 delta Scuti stars. Using several possible assumptions for the origin of the spacings, we derived the large separation ($\Delta\nu$), which are distributed along the mean density versus large separations relation derived from stellar models Suarez 2014.Comment: 25 pages, 16 figures, 9 tables. Accepted for publication in ApJ

Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms

Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes. Moreover, patients with hypertension often exhibit insulin resistance and are at greater risk of diabetes developing than are normotensive individuals. The major cause of morbidity and mortality in diabetes is cardiovascular disease, which is exacerbated by hypertension. Accordingly, diabetes and hypertension are closely interlinked because of similar risk factors, such as endothelial dysfunction, vascular inflammation, arterial remodelling, atherosclerosis, dyslipidemia, and obesity. There is also substantial overlap in the cardiovascular complications of diabetes and hypertension related primarily to microvascular and macrovascular disease. Common mechanisms, such as upregulation of the renin-angiotensin-aldosterone system, oxidative stress, inflammation, and activation of the immune system likely contribute to the close relationship between diabetes and hypertension. In this article we discuss diabetes and hypertension as comorbidities and discuss the pathophysiological features of vascular complications associated with these conditions. We also highlight some vascular mechanisms that predispose to both conditions, focusing on advanced glycation end products, oxidative stress, inflammation, the immune system, and microRNAs. Finally, we provide some insights into current therapies targeting diabetes and cardiovascular complications and introduce some new agents that may have vasoprotective therapeutic potential in diabetes

Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis

Background and Purpose: Inflammation plays a key role in atherosclerosis. A protective role of angiotensin-(1-7) in vascular pathologies opened a possibility for therapeutic use of small molecule non-peptide Ang-(1-7) mimetics, such as AVE0991. The mechanisms of these vaso-protective effects of a Mas receptor agonist, AVE0991, remain unclear. Experimental approach: We investigated the effects of AVE0991 on the spontaneous atherosclerosis in ApoE-/- mice, in the context of vascular inflammation and plaque stability. Key Results: AVE0991 has significant anti-atherosclerotic properties in ApoE-/- mice and increases plaque stability, by reducing plaque macrophage content, without effects on collagen. Using descending aorta of chow fed ApoE-/- mice, before significant atherosclerotic plaque develops, we gained insight to early events in atherosclerosis. Interestingly, perivascular adipose tissue (pVAT) and adventitial infiltration with macrophages and T cells precedes atherosclerotic plaque or the impairment of endothelium-dependent NO bioavailability as a measure of endothelial function. AVE0991 inhibited perivascular inflammation, through the reduction of chemokine expression in pVAT, as well as through direct actions on monocytes/macrophages inhibiting their activation, characterized by IL-1β, TNF-α, MCP-1 and CXCL10 and differentiation to M1 phenotype. Pre-treatment with AVE0991 inhibited migration of THP-1 monocytes towards supernatants of activated adipocytes (SW872). Mas receptors were expressed in pVAT and in THP-1 cells in vitro and anti-inflammatory effects of AVE0991 were partially Mas dependent. Conclusions & implications: Selective Mas receptor agonist AVE0991 possesses anti-atherosclerotic and anti-inflammatory properties, affecting monocyte/macrophage differentiation and recruitment to perivascular space at early stages of atherosclerosis in ApoE-/- mice

Zasady obowiązywania ustawy karnej względem cudzoziemców w polskim systemie prawa materialnego

Uniwersytet w Białymstok

A Quantum-Quantum Metropolis Algorithm

Recently, the idea of classical Metropolis sampling through Markov chains has been generalized for quantum Hamiltonians. However, the underlying Markov chain of this algorithm is still classical in nature. Due to Szegedy's method, the Markov chains of classical Hamiltonians can achieve a quadratic quantum speedup in the eigenvalue gap of the corresponding transition matrix. A natural question to ask is whether Szegedy's quantum speedup is merely a consequence of employing classical Hamiltonians, where the eigenstates simply coincide with the computational basis, making cloning of the classical information possible. We solve this problem by introducing a quantum version of the method of Markov-chain quantization combined with the quantum simulated annealing (QSA) procedure, and describe explicitly a novel quantum Metropolis algorithm, which exhibits a quadratic quantum speedup in the eigenvalue gap of the corresponding Metropolis Markov chain for any quantum Hamiltonian. This result provides a complete generalization of the classical Metropolis method to the quantum domain.Comment: 7 page

An Active Broad Area Cooling Model of a Cryogenic Propellant Tank with a Single Stage Reverse Turbo-Brayton Cycle Cryocooler

As focus shifts towards long-duration space exploration missions, an increased interest in active thermal control of cryogenic propellants to achieve zero boil-off of cryogens has emerged. An active thermal control concept of considerable merit is the integration of a broad area cooling system for a cryogenic propellant tank with a combined cryocooler and circulator system that can be used to reduce or even eliminate liquid cryogen boil-off. One prospective cryocooler and circulator combination is the reverse turbo-Brayton cycle cryocooler. This system is unique in that it has the ability to both cool and circulate the coolant gas efficiently in the same loop as the broad area cooling lines, allowing for a single cooling gas loop, with the primary heat rejection occurring by way of a radiator and/or aftercooler. Currently few modeling tools exist that can size and characterize an integrated reverse turbo-Brayton cycle cryocooler in combination with a broad area cooling design. This paper addresses efforts to create such a tool to assist in gaining a broader understanding of these systems, and investigate their performance in potential space missions. The model uses conventional engineering and thermodynamic relationships to predict the preliminary design parameters, including input power requirements, pressure drops, flow rate, cycle performance, cooling lift, broad area cooler line sizing, and component operating temperatures and pressures given the cooling load operating temperature, heat rejection temperature, compressor inlet pressure, compressor rotational speed, and cryogenic tank geometry. In addition, the model allows for the preliminary design analysis of the broad area cooling tubing, to determine the effect of tube sizing on the reverse turbo-Brayton cycle system performance. At the time this paper was written, the model was verified to match existing theoretical documentation within a reasonable margin. While further experimental data is needed for full validation, this tool has already made significant steps towards giving a clearer understanding of the performance of a reverse turbo-Brayton cycle cryocooler integrated with broad area cooling technology for zero boil-off active thermal control

Tests of Gravity from Imaging and Spectroscopic Surveys

Tests of gravity on large-scales in the universe can be made using both imaging and spectroscopic surveys. The former allow for measurements of weak lensing, galaxy clustering and cross-correlations such as the ISW effect. The latter probe galaxy dynamics through redshift space distortions. We use a set of basic observables, namely lensing power spectra, galaxy-lensing and galaxy-velocity cross-spectra in multiple redshift bins (including their covariances), to estimate the ability of upcoming surveys to test gravity theories. We use a two-parameter description of gravity that allows for the Poisson equation and the ratio of metric potentials to depart from general relativity. We find that the combination of imaging and spectroscopic observables is essential in making robust tests of gravity theories. The range of scales and redshifts best probed by upcoming surveys is discussed. We also compare our parametrization to others used in the literature, in particular the gamma parameter modification of the growth factor.Comment: 18 pages, 10 figures, to be submitte