214 research outputs found
Role of Protective Relaying in the Smart Grid
This paper discusses the role of protective relaying in a Smart Grid. It outlines the definition, attributes, and benefits of a Smart Grid. The role that protective relays can play in implementing Smart Grid functionality and the impact that a Smart Grid design may have on modern protective relays is discussed. Specific examples of Smart Grid applications that may be implemented using modern protective relays and other intelligent electronic devices are provided
Language Identification in Short Utterances Using Long Short-Term Memory (LSTM) Recurrent Neural Networks
Zazo R, Lozano-Diez A, Gonzalez-Dominguez J, T. Toledano D, Gonzalez-Rodriguez J (2016) Language Identification in Short Utterances Using Long Short-Term Memory (LSTM) Recurrent Neural Networks. PLoS ONE 11(1): e0146917. doi:10.1371/journal.pone.0146917Long Short Term Memory (LSTM) Recurrent Neural Networks (RNNs) have recently outperformed other state-of-the-art approaches, such as i-vector and Deep Neural Networks (DNNs), in automatic Language Identification (LID), particularly when dealing with very short utterances (similar to 3s). In this contribution we present an open-source, end-to-end, LSTM RNN system running on limited computational resources (a single GPU) that outperforms a reference i-vector system on a subset of the NIST Language Recognition Evaluation (8 target languages, 3s task) by up to a 26%. This result is in line with previously published research using proprietary LSTM implementations and huge computational resources, which made these former results hardly reproducible. Further, we extend those previous experiments modeling unseen languages (out of set, OOS, modeling), which is crucial in real applications. Results show that a LSTM RNN with OOS modeling is able to detect these languages and generalizes robustly to unseen OOS languages. Finally, we also analyze the effect of even more limited test data (from 2.25s to 0.1s) proving that with as little as 0.5s an accuracy of over 50% can be achieved.This work has been supported by project CMC-V2: Caracterizacion, Modelado y Compensacion de Variabilidad en la Señal de Voz (TEC2012-37585-C02-01), funded by Ministerio de Economia y Competitividad, Spain
GNOSIS: the first instrument to use fibre Bragg gratings for OH suppression
GNOSIS is a prototype astrophotonic instrument that utilizes OH suppression
fibres consisting of fibre Bragg gratings and photonic lanterns to suppress the
103 brightest atmospheric emission doublets between 1.47-1.7 microns. GNOSIS
was commissioned at the 3.9-meter Anglo-Australian Telescope with the IRIS2
spectrograph to demonstrate the potential of OH suppression fibres, but may be
potentially used with any telescope and spectrograph combination. Unlike
previous atmospheric suppression techniques GNOSIS suppresses the lines before
dispersion and in a manner that depends purely on wavelength. We present the
instrument design and report the results of laboratory and on-sky tests from
commissioning. While these tests demonstrated high throughput and excellent
suppression of the skylines by the OH suppression fibres, surprisingly GNOSIS
produced no significant reduction in the interline background and the
sensitivity of GNOSIS and IRIS2 is about the same as IRIS2. It is unclear
whether the lack of reduction in the interline background is due to physical
sources or systematic errors as the observations are detector noise-dominated.
OH suppression fibres could potentially impact ground-based astronomy at the
level of adaptive optics or greater. However, until a clear reduction in the
interline background and the corresponding increasing in sensitivity is
demonstrated optimized OH suppression fibres paired with a fibre-fed
spectrograph will at least provide a real benefits at low resolving powers.Comment: 15 pages, 13 figures, accepted to A
Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice
HIV diversification facilitates immune escape and complicates antiretroviral therapy. In this study, we take advantage of a humanized mouse model to probe the contribution of APOBEC3 mutagenesis to viral evolution. Humanized mice were infected with isogenic HIV molecular clones (HIV-WT, HIV-45G, HIV-ΔSLQ) that differ in their ability to counteract APOBEC3G (A3G). Infected mice remained naïve or were treated with the RT inhibitor lamivudine (3TC). Viremia, emergence of drug resistant variants and quasispecies diversification in the plasma compartment were determined throughout infection. While both HIV-WT and HIV-45G achieved robust infection, over time HIV-45G replication was significantly reduced compared to HIV-WT in the absence of 3TC treatment. In contrast, treatment response differed significantly between HIV-45G and HIV-WT infected mice. Antiretroviral treatment failed in 91% of HIV-45G infected mice while only 36% of HIV-WT infected mice displayed a similar negative outcome. Emergence of 3TC resistant variants and nucleotide diversity were determined by analyzing 155,462 single HIV reverse transcriptase (RT) and 6,985 vif sequences from 33 mice. Prior to treatment, variants with genotypic 3TC resistance (RT-M184I/V) were detected at low levels in over a third of all animals. Upon treatment, the composition of the plasma quasispecies rapidly changed leading to a majority of circulating viral variants encoding RT-184I. Interestingly, increased viral diversity prior to treatment initiation correlated with higher plasma viremia in HIV-45G but not in HIV-WT infected animals. Taken together, HIV variants with suboptimal anti-A3G activity were attenuated in the absence of selection but display a fitness advantage in the presence of antiretroviral treatment.IMPORTANCE Both viral (e.g., reverse transcriptase, RT) and host factors (e.g., APOBEC3G (A3G)) can contribute to HIV sequence diversity. This study shows that suboptimal anti-A3G activity shapes viral fitness and drives viral evolution in the plasma compartment of humanized mice
Sunscreens - Which and what for?
It is well established that sun exposure is the main cause for the development of skin cancer. Chronic continuous UV radiation is believed to induce malignant melanoma, whereas intermittent high-dose UV exposure contributes to the occurrence of actinic keratosis as precursor lesions of squamous cell carcinoma as well as basal cell carcinoma. Not only photocarcinogenesis but also the mechanisms of photoaging have recently become apparent. In this respect the use of sunscreens seemed to prove to be more and more important and popular within the last decades. However, there is still inconsistency about the usefulness of sunscreens. Several studies show that inadequate use and incomplete UV spectrum efficacy may compromise protection more than previously expected. The sunscreen market is crowded by numerous products. Inorganic sunscreens such as zinc oxide and titanium oxide have a wide spectral range of activity compared to most of the organic sunscreen products. It is not uncommon for organic sunscreens to cause photocontact allergy, but their cosmetic acceptability is still superior to the one given by inorganic sunscreens. Recently, modern galenic approaches such as micronization and encapsulation allow the development of high-quality inorganic sunscreens. The potential systemic toxicity of organic sunscreens has lately primarily been discussed controversially in public, and several studies show contradictory results. Although a matter of debate, at present the sun protection factor (SPF) is the most reliable information for the consumer as a measure of sunscreen filter efficacy. In this context additional tests have been introduced for the evaluation of not only the protective effect against erythema but also protection against UV-induced immunological and mutational effects. Recently, combinations of UV filters with agents active in DNA repair have been introduced in order to improve photoprotection. This article reviews the efficacy of sunscreens in the prevention of epithelial and nonepithelial skin cancer, the effect on immunosuppression and the value of the SPF as well as new developments on the sunscreen market. Copyright (C) 2005 S. Karger AG, Basel
Suppression of the near-infrared OH night sky lines with fibre Bragg gratings - first results
The background noise between 1 and 1.8 microns in ground-based instruments is
dominated by atmospheric emission from hydroxyl molecules. We have built and
commissioned a new instrument, GNOSIS, which suppresses 103 OH doublets between
1.47 - 1.7 microns by a factor of ~1000 with a resolving power of ~10,000. We
present the first results from the commissioning of GNOSIS using the IRIS2
spectrograph at the AAT. The combined throughput of the GNOSIS fore-optics,
grating unit and relay optics is ~36 per cent, but this could be improved to
~46 per cent with a more optimal design. We measure strong suppression of the
OH lines, confirming that OH suppression with fibre Bragg gratings will be a
powerful technology for low resolution spectroscopy. The integrated OH
suppressed background between 1.5 and 1.7 microns is reduced by a factor of 9
compared to a control spectrum using the same system without suppression. The
potential of low resolution OH suppressed spectroscopy is illustrated with
example observations.
The GNOSIS background is dominated by detector dark current below 1.67
microns and by thermal emission above 1.67 microns. After subtracting these we
detect an unidentified residual interline component of ~ 860 +/ 210
ph/s/m^2/micron/arcsec^2. This component is equally bright in the suppressed
and control spectra. We have investigated the possible source of the interline
component, but were unable to discriminate between a possible instrumental
artifact and intrinsic atmospheric emission. Resolving the source of this
emission is crucial for the design of fully optimised OH suppression
spectrographs. The next generation OH suppression spectrograph will be focussed
on resolving the source of the interline component, taking advantage of better
optimisation for a FBG feed. We quantify the necessary improvements for an
optimal OH suppressing fibre spectrograph design.Comment: Accepted for publication in MNRAS. 15 pages, 18 figure
Star-forming cores embedded in a massive cold clump: Fragmentation, collapse and energetic outflows
The fate of massive cold clumps, their internal structure and collapse need
to be characterised to understand the initial conditions for the formation of
high-mass stars, stellar systems, and the origin of associations and clusters.
We explore the onset of star formation in the 75 M_sun SMM1 clump in the region
ISOSS J18364-0221 using infrared and (sub-)millimetre observations including
interferometry. This contracting clump has fragmented into two compact cores
SMM1 North and South of 0.05 pc radius, having masses of 15 and 10 M_sun, and
luminosities of 20 and 180 L_sun. SMM1 South harbours a source traced at 24 and
70um, drives an energetic molecular outflow, and appears supersonically
turbulent at the core centre. SMM1 North has no infrared counterparts and shows
lower levels of turbulence, but also drives an outflow. Both outflows appear
collimated and parsec-scale near-infrared features probably trace the
outflow-powering jets. We derived mass outflow rates of at least 4E-5 M_sun/yr
and outflow timescales of less than 1E4 yr. Our HCN(1-0) modelling for SMM1
South yielded an infall velocity of 0.14 km/s and an estimated mass infall rate
of 3E-5 M_sun/yr. Both cores may harbour seeds of intermediate- or high-mass
stars. We compare the derived core properties with recent simulations of
massive core collapse. They are consistent with the very early stages dominated
by accretion luminosity.Comment: Accepted for publication in ApJ, 14 pages, 7 figure
Restoring speech following total removal of the larynx by a learned transformation from sensor data to acoustics
Total removal of the larynx may be required to treat laryngeal cancer: speech is lost. This article shows that it may be possible to restore speech by sensing movement of the remaining speech articulators and use machine learning algorithms to derive a transformation to convert this sensor data into an acoustic signal. The resulting “silent speech,” which may be delivered in real time, is intelligible and sounds natural. The identity of the speaker is recognisable. The sensing technique involves attaching small, unobtrusive magnets to the lips and tongue and monitoring changes in the magnetic field induced by their movement
Keck all sky precision adaptive optics: project overview
We present the status and plans for the Keck All sky Precision Adaptive optics (KAPA) program. KAPA includes four key science programs, an upgrade to the Keck I laser guide star (LGS) adaptive optics (AO) facility to improve image quality and sky coverage, AO telemetry based point spread function (PSF) estimates for all science exposures, and an educational component focused on broadening the participation of women and underrepresented groups in instrumentation. For the purpose of this conference we will focus on the AO facility upgrade which includes implementation of a new laser, wavefront sensor and real-time controller to support laser tomography, the laser tomography system itself, and modifications to an existing near-infrared tip-tilt sensor to support multiple natural guide star (NGS) and focus measurements
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