18 research outputs found
Metastatic Invasive Lobular Carcinoma of the Breast Masquerading as a Primary Renal Malignancy
Breast cancer is known to metastasise to different organs in the body, but an initial presentation of breast cancer with loin pain secondary to a metastatic renal mass is extremely rare. We report a 58-year-old woman who presented with recurrent left loin pain due to a metastatic deposit of invasive lobular carcinoma of the breast. The detection of a renal mass on computed tomography led to the assumption of a renal pelvic malignancy. The diagnostic dilemma posed by the detection of a breast mass during staging and the usefulness of immunohistochemistry in the confirmation of diagnosis are discussed
Complete Chloroplast Genomes of Anthurium huixtlense and Pothos scandens (Pothoideae, Araceae) : Unique Inverted Repeat Expansion and Contraction Affect Rate of Evolution
The subfamily Pothoideae belongs to the ecologically important plant family Araceae. Here, we report the chloroplast genomes of two species of the subfamily Pothoideae:Anthurium huixtlense(size: 163,116 bp) andPothos scandens(size: 164,719 bp). The chloroplast genome ofP. scandensshowed unique contraction and expansion of inverted repeats (IRs), thereby increasing the size of the large single-copy region (LSC: 102,956 bp) and decreasing the size of the small single-copy region (SSC: 6779 bp). This led to duplication of many single-copy genes due to transfer to IR regions from the small single-copy (SSC) region, whereas some duplicate genes became single copy due to transfer to large single-copy regions. The rate of evolution of protein-coding genes was affected by the contraction and expansion of IRs; we found higher mutation rates for genes that exist in single-copy regions as compared to those in IRs. We found a 2.3-fold increase of oligonucleotide repeats inP. scandenswhen compared withA. huixtlense, whereas amino acid frequency and codon usage revealed similarities. The ratio of transition to transversion mutations was 2.26 inP. scandensand 2.12 inA. huixtlense. Transversion mutations mostly translated in non-synonymous substitutions. The phylogenetic inference of the limited species showed the monophyly of the Araceae subfamilies. Our study provides insight into the molecular evolution of chloroplast genomes in the subfamily Pothoideae and family Araceae.Peer reviewe
Thermally activated reorientation of di-interstitial defects in silicon
We propose a di-interstitial model for the P6 center commonly observed in ion
implanted silicon. The di-interstitial structure and transition paths between
different defect orientations can explain the thermally activated transition of
the P6 center from low-temperature C1h to room-temperature D2d symmetry. The
activation energy for the defect reorientation determined by ab initio
calculations is 0.5 eV in agreement with the experiment. Our di-interstitial
model establishes a link between point defects and extended defects,
di-interstitials providing the nuclei for the growth.Comment: 12 pages, REVTeX, Four figures, submitted to Phys. Rev. Let
Green HRM and employee efficiency: the mediating role of employee motivation in emerging small businesses
The modern organizational structure expects that the human resource department should train the employees effectively to sustain the environment. This study aims to understand the role of green human resource management (GHRM) in the efficiency of organizations’ employees in small and medium enterprises (SMEs) of Pakistan. The questionnaire was developed on a five-point Likert scale to collect primary data from the target respondents, and the target respondents of this study were the employees of SMEs in Pakistan. The results of the study indicate that GHRM is an important tool to motivate and train employees, which ultimately increases the efficiency of employees. This study demonstrates that the SMEs in Pakistan need to consider the critical role of GHRM as it is emerging and provides reliable resources as per the organization’s requirements for better performance. This study provides recommendation for future studies to consider and contribute to the literature and to the practices of SMEs in Pakistan for the efficiency of their employees
Malignant neuroendocrine tumour of the gallbladder with elevated carcinoembryonic antigen: case report and literature review
Association ofSOD3 promoter DNA methylation with its down-regulation in breast carcinomas
Analysis of glacial meltwater in Bagrot Valley, Karakoram, based on short term ablation and debris cover observations on Hinarche Glacier
People in the Karakoram
use discharge from
glaciers during summer
for irrigation and other
purposes. While the
glacial meltwater supply
during hot and dry periods
will vary as a result of
climate change,
Karakoram glaciers so far
have not shown a consistent reaction to climatic change,
although climate scenarios indicate severe future impacts in
the high-elevation regions of the Himalaya and Karakoram.
Field measurements on Hinarche Glacier in Bagrot Valley are
combined with remote sensing information and climate
observations to investigate the meltwater production of the
glacier and estimate the meltwater discharge in the valley.Special emphasis was placed on ice melt beneath
supraglacial debris, which is the common process on the
glacier tongues in the region. The calculated annual meltwater
production of about 135 million m3 for Hinarche Glacier shows
the order of magnitude for glacier runoff in such environments.
Glacial meltwater production is about 300 million m3 per year
for the entire valley under balanced conditions. This analysis
serves as a basis for further investigations concerning
temporal meltwater variability and potential water usage by
the local population