The evolution of H{\sc ii} galaxies: Testing the bursting scenario through the use of self-consistent models

We have computed a series of realistic and self-consistent models of the emitted spectra of H{\sc ii} galaxies. Our models combine different codes of chemical evolution, evolutionary population synthesis and photoionization. The emitted spectrum of H{\sc ii} galaxies is reproduced by means of the photoionization code CLOUDY, using as ionizing spectrum the spectral energy distribution of the modelled H{\sc ii} galaxy, which in turn is calculated according to a Star Formation History (SFH) and a metallicity evolution given by a chemical evolution model that follows the abundances of 15 different elements. The contribution of emission lines to the broad-band colours is explicitly taken into account. The results of our code are compared with photometric and spectroscopic data of H{\sc ii} galaxies. Our technique reproduces observed diagnostic diagrams, abundances, equivalent width-colour and equivalent width-metallicity relations for local H{\sc ii} galaxies.Comment: 13 figures and 2 tables, accepted for publication in MNRAS Main Journa

A Supersymmetric Solution to the Solar and Atmospheric Neutrino Problems

The simplest unified extension of the Minimal Supersymmetric Standard Model with bi-linear R--Parity violation provides a predictive scheme for neutrino masses which can account for the observed atmospheric and solar neutrino anomalies in terms of bi-maximal neutrino mixing. The maximality of the atmospheric mixing angle arises dynamically, by minimizing the scalar potential, while the solar neutrino problem can be accounted for either by large or by small mixing oscillations. One neutrino picks up mass by mixing with neutralinos, while the degeneracy and masslessness of the other two is lifted only by loop corrections. Despite the smallness of neutrino masses R-parity violation is observable at present and future high-energy colliders, providing an unambiguous cross-check of the model.Comment: 5 pages, final version published in Phys. Rev. D61, 2000, 071703(R

Intravitreal bevacizumab (Avastin) for choroidal metastasis secondary to breast carcinoma: short-term follow-up

Uveal metastases are the most common intraocular malignancy. The most common primary sites of cancer are from the breast (47%) and lung (21%).1 The treatment for choroidal metastasis depends on many factors including location, multiplicity, and activity of each tumour.1 Bevacizumab (Avastins) is a full-length humanized murine monoclonal antibody against the VEGF molecule, and inhibits angiogenesis and tumour growth.2 In this report, we describe the effect of a single intravitreal injection of bevacizumab (4 mg) in a patient with choroidal metastasis secondary to breast cancerMedicin

Neutrino Masses and Mixings from Supersymmetry with Bilinear R--Parity Violation: A Theory for Solar and Atmospheric Neutrino Oscillations

The simplest unified extension of the MSSM with bi-linear R--Parity violation naturally predicts a hierarchical neutrino mass spectrum, in which one neutrino acquires mass by mixing with neutralinos, while the other two get mass radiatively. We have performed a full one-loop calculation of the neutralino-neutrino mass matrix in the bi-linear \rp MSSM, taking special care to achieve a manifestly gauge invariant calculation. Moreover we have performed the renormalization of the heaviest neutrino, needed in order to get meaningful results. The atmospheric mass scale and maximal mixing angle arise from tree-level physics, while solar neutrino scale and oscillations follow from calculable one-loop corrections. If universal supergravity assumptions are made on the soft-supersymmetry breaking terms then the atmospheric scale is calculable as a function of a single \rp violating parameter by the renormalization group evolution due to the non-zero bottom quark Yukawa coupling. The solar neutrino problem must be accounted for by the small mixing angle (SMA) MSW solution. If these assumptions are relaxed then one can implement large mixing angle solutions, either MSW or just-so. The theory predicts the lightest supersymmetic particle (LSP) decay to be observable at high-energy colliders, despite the smallness of neutrino masses indicated by experiment. This provides an independent way to test this solution of the atmospheric and solar neutrino anomalies.Comment: 46 pages, references added + several misprints correcte

Working towards a consensus on the oncological approach of breakthrough pain: A Delphi survey of Spanish experts

Purpose: There is a lack of standards for the diagnosis, assessment and management of breakthrough cancer pain (BTcP). La Fundación ECO (the Foundation for Excellence and Quality in Oncology) commissioned a study to establish a consensus and lay the foundations for the appropriate management of BTcP in oncology patients. Patients and methods: A modified Delphi survey comprising two rounds was used to gather and analyze data, which was conducted over the Internet. Each statement that reached a consensus with the respondents was defined as a median consensus score (MED) of =7, and agreement among panelists as an interquartile range (IQR) of =3. Results: In total, 69 medical oncologists responded, with a broad consensus that BTcP implied exacerbations of high-intensity pain, as opposed to moderate pain. Furthermore, they concurred that appropriate diagnostic equipment is needed, and that rapid-onset fentanyl formulations should be the preferred treatment for BTcP management. The panelists agreed that a lack of appropriate information and training to attend to patients, as well as limited patient visitation rights, were barriers to effective BTcP management. Regarding gaps in detected knowledge, the panelists were unsure of the measures necessary to assess the burden of the disease on the patient’s quality of life and associated medication costs. Alongside this, there was a lack of awareness of the technical specifics of the different formulations of rapid-onset fentanyl. Conclusion: These results represent the current status of BTcP management. They may inform recommendations and provide a framework for future research

Dynamical coupled-channel approaches on a momentum lattice

Dynamical coupled-channel approaches are a widely used tool in hadronic physics that allow to analyze different reactions and partial waves in a consistent way. In such approaches the basic interactions are derived within an effective Lagrangian framework and the resulting pseudo-potentials are then unitarized in a coupled-channel scattering equation. We propose a scheme that allows for a solution of the arising integral equation in discretized momentum space for periodic as well as twisted boundary conditions. This permits to study finite size effects as they appear in lattice QCD simulations. The new formalism, at this stage with a restriction to S-waves, is applied to coupled-channel models for the sigma(600), f0(980), and a0(980) mesons, and also for the Lambda(1405) baryon. Lattice spectra are predicted.Comment: 7 pages, 4 figure

Testing neutrino mixing at future collider experiments

Low energy supersymmetry with bilinear breaking of R-parity leads to a weak-scale seesaw mechanism for the atmospheric neutrino scale and a radiative mechanism for the solar neutrino scale. The model has striking implications for collider searches of supersymmetric particles. Assuming that the lightest SUSY particle is the lightest neutralino we demonstrate that (i) The neutralino decays inside the detector even for tiny neutrino masses. (ii) Measurements of the neutrino mixing angles lead to predictions for the ratios of various neutralino branching ratios implying an independent test of neutrino physics at future colliders, such as the Large Hadron Collider or a Linear Collider.Comment: LaTex, 35 pages, 20 figures included, version 2, section on model shortened, Fig. 13 replaced, typos corrected, version to appear in Phys.Rev.

Probing neutrino properties with charged scalar lepton decays

Supersymmetry with bilinear R-parity violation provides a predictive framework for neutrino masses and mixings in agreement with current neutrino oscillation data. The model leads to striking signals at future colliders through the R-parity violating decays of the lightest supersymmetric particle. Here we study charged scalar lepton decays and demonstrate that if the scalar tau is the LSP (i) it will decay within the detector, despite the smallness of the neutrino masses, (ii) the relative ratio of branching ratios Br({tilde tau}_1 --> e sum nu_i)/ Br({tilde tau}_1 --> mu sum nu_i) is predicted from the measured solar neutrino angle, and (iii) scalar muon and scalar electron decays will allow to test the consistency of the model. Thus, bilinear R-parity breaking SUSY will be testable at future colliders also in the case where the LSP is not the neutralino.Comment: 24 pages, 8 ps figs Report-no.: IFIC/02-33 and ZU-TH 11/0