Unification via intermediate symmetry breaking scales with the quartification gauge group

The idea of quark-lepton universality at high energies has been introduced as a natural extension to the standard model. This is achieved by endowing leptons with new degrees of freedom -- leptonic colour, an analogue of the familiar quark colour. Grand and partially unified models which utilise this new gauge symmetry SU(3)_\ell have been proposed in the context of the quartification gauge group SU(3)^4. Phenomenologically successful gauge coupling constant unification without supersymmetry has been demonstrated for cases where the symmetry breaking leaves a residual SU(2)_\ell unbroken. Though attractive, these schemes either incorporate ad hoc discrete symmetries and non-renormalisable mass terms, or achieve only partial unification. We show that grand unified models can be constructed where the quartification group can be broken fully [i.e. no residual SU(2)_\ell] to the standard model gauge group without requiring additional discrete symmetries or higher dimension operators. These models also automatically have suppressed nonzero neutrino masses. We perform a systematic analysis of the renormalisation-group equations for all possible symmetry breaking routes from SU(3)^4 --> SU(3)_q x SU(2)_L x U(1)_Y. This analysis indicates that gauge coupling unification can be achieved for several different symmetry breaking patterns and we outline the requirements that each gives on the unification scale. We also show that the unification scenarios of those models which leave a residual SU(2)_\ell symmetry are not unique. In both symmetry breaking cases, some of the scenarios require new physics at the TeV scale, while others do not allow for new TeV phenomenology in the fermionic sector.Comment: 25 page

Immune sensing of nucleic acids in inflammatory skin diseases.

Endosomal and cytosolic nucleic acid receptors are important immune sensors required for the detection of infecting or replicating viruses. The intracellular location of these receptors allows viral recognition and, at the same time, avoids unnecessary immune activation to self-nucleic acids that are continuously released by dying host cells. Recent evidence, however, indicates that endogenous factors such as anti-microbial peptides have the ability to break this protective mechanism. Here, we discuss these factors and illustrate how they drive inflammatory responses by promoting immune recognition of self-nucleic acids in skin wounds and inflammatory skin diseases such as psoriasis and lupus

A Senescence-Centric View of Aging:Implications for Longevity and Disease

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular alterations and secretion of proinflammatory cytokines and molecules. From their initial discovery in the 1960s, senescent cells have been hypothesized as potential contributors to the age-associated loss of regenerative potential. Here, we discuss recent evidence that implicates cellular senescence as a central regulatory mechanism of the aging process. We provide a comprehensive overview of age-associated pathologies in which cellular senescence has been implicated. We describe mechanisms by which senescent cells drive aging and diseases, and we discuss updates on exploiting these mechanisms as therapeutic targets. Finally, we critically analyze the use of senotherapeutics and their translation to the clinic, highlighting limitations and suggesting ideas for future applications and developments

Spaces of Memory

In the last decade, museums, memorials and monuments have become the battlefield for competing and conflicting visions of the past and the hegemonic or counter memories of the so-called “difficult heritage” or “traumatic heritage”. Far from being mere spaces of musealization that freeze and fix dominant narratives of the past, spaces of memory are increasingly turning into sites of negotiations and reconfigurations of meaning in which social and political identities are debated, strengthened, or weakened in reference to the traumatic experiences of the past which they “represent”. Yet, what does it mean to spatially represent a (traumatic) memory, and what is a space of memory? In expanding and, simultaneously, problematizing Pierre Nora’s (Nora 1996) category of lieu de mémoire, the way we think of spaces of memory aims at an in-depth examination of the peculiar yet specific ways of re-thinking the nexus between space and memory: how do we elaborate, activate, and make visible spaces for memory? This question points to the dynamic construction that underlines the production and connection of spatiality and memory, as well as to the coexistence of a plurality of meanings and experiences that characterize spaces of memory

Assessment of left atrial volume before and after pulmonary thromboendarterectomy in chronic thromboembolic pulmonary hypertension.

BackgroundImpaired left ventricular diastolic filling is common in chronic thromboembolic pulmonary hypertension (CTEPH), and recent studies support left ventricular underfilling as a cause. To investigate this further, we assessed left atrial volume index (LAVI) in patients with CTEPH before and after pulmonary thromboendarterectomy (PTE).MethodsForty-eight consecutive CTEPH patients had pre- & post-PTE echocardiograms and right heart catheterizations. Parameters included mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), cardiac index, LAVI, & mitral E/A ratio. Echocardiograms were performed 6 ± 3 days pre-PTE and 10 ± 4 days post-PTE. Regression analyses compared pre- and post-PTE LAVI with other parameters.ResultsPre-op LAVI (mean 19.0 ± 7 mL/m2) correlated significantly with pre-op PVR (R = -0.45, p = 0.001), mPAP (R = -0.28, p = 0.05) and cardiac index (R = 0.38, p = 0.006). Post-PTE, LAVI increased by 18% to 22.4 ± 7 mL/m2 (p = 0.003). This change correlated with change in PVR (765 to 311 dyne-s/cm5, p = 0.01), cardiac index (2.6 to 3.2 L/min/m2, p = 0.02), and E/A (.95 to 1.44, p = 0.002).ConclusionIn CTEPH, smaller LAVI is associated with lower cardiac output, higher mPAP, and higher PVR. LAVI increases by ~20% after PTE, and this change correlates with changes in PVR and mitral E/A. The rapid increase in LAVI supports the concept that left ventricular diastolic impairment and low E/A pre-PTE are due to left heart underfilling rather than inherent left ventricular diastolic dysfunction

Obesity as a risk factor for severe influenza-like illness

Background: Obesity was recognized as in independent risk factor for influenza during the 2009 H1N1 influenza pandemic. Objectives: We evaluated the association between body mass index (BMI) and influenza-like illness (ILI) during two non-pandemic influenza seasons (2003–2004 and 2004–2005) and during the spring and fall waves of the 2009 H1N1 pandemic. Methods: Adults with severe (inpatient) and mild (outpatient) ILI were compared to those without ILI using a case-cohort design. The study was nested among those insured by a single health insurance company, receiving care from a large multispecialty practice. Data were collected from insurance claims and the electronic health record. The primary exposure was obesity (BMI ≥ 30·0 kg/m2). Results: Across three seasons, the crude and adjusted ORs for obesity and severe ILI were 1·65 (95% CI 1·31, 2·08) and 1·23 (95% CI 0·97, 1·57), respectively. An association was observed for those aged 20–59 years (adjusted OR 1·92, 95% CI 1·26, 2·90), but not for those 60 and older (adjusted OR 1·08, 95% CI 0·80, 1·46). The adjusted ORs for obesity and severe ILI in 2003–2004, 2004–2005, and during H1N1 were 1·14 (95% CI 0·80, 1·64), 1·24 (95% CI 0·86, 1·79), and 1·76 (95% CI 0·91, 3·42), respectively. Among those with a Charlson Comorbidity Index score of zero, the adjusted ORs for 2003–2004, 2004–2005, and H1N1 were 1·60 (95% CI 0·93, 2·76), 1·43 (95% CI 0·80, 2·56), and 1·90 (95% CI 0·68, 5·27), respectively. Conclusions: Our results suggest a small to moderate association between obesity and hospitalized ILI among adults

È VIVO: Virtual eruptions at Vesuvius; A multimedia tool to illustrate numerical modeling to a general public

Dissemination of scientific results to the general public has become increasingly important in our society. When science deals with natural hazards, public outreach is even more important: on the one hand, it contributes to hazard perception and it is a necessary step toward preparedness and risk mitigation; on the other hand, it contributes to establish a positive link of mutual confidence between scientific community and the population living at risk. The existence of such a link plays a relevant role in hazard communication, which in turn is essential to mitigate the risk. In this work, we present a tool that we have developed to illustrate our scientific results on pyroclastic flow propagation at Vesuvius. This tool, a CD-ROM that we developed joining scientific data with appropriate knowledge in communication sciences is meant to be a first prototype that will be used to test the validity of this approach to public outreach. The multimedia guide contains figures, images of real volcanoes and computer animations obtained through numerical modeling of pyroclastic density currents. Explanatory text, kept as short and simple as possible, illustrates both the process and the methodology applied to study this very dangerous natural phenomenon. In this first version, the CD-ROM will be distributed among selected categories of end-users together with a short questionnaire that we have drawn to test its readability. Future releases will include feedback from the users, further advancement of scientific results as well as a higher degree of interactivity

Five-dimensional Trinification Improved

We present improved models of trinification in five dimensions. Unified symmetry is broken by a combination of orbifold projections and a boundary Higgs sector. The latter can be decoupled from the theory, realizing a Higgsless limit in which the scale of exotic massive gauge fields is set by the compactification radius. Electroweak Higgs doublets are identified with the fifth components of gauge fields and Yukawa interactions arise via Wilson loops. The result is a simple low-energy effective theory that is consistent with the constraints from proton decay and gauge unification.Comment: 13 pages LaTeX. v2: reference adde