Optimizing Neutron Yield for Active Interrogation

Neutrons are commonly used for many applications, including active interrogation and cancer therapy. One critical aspect for active interrogation efficiency is neutron yield, which is more important for successful resolution than the energy spectrum. The typical approach for improving neutron yield entails producing more neutrons, which has motivated multiple studies using the interaction of increasingly more powerful tabletop lasers with plastic targets to generate protons or deuterons that are absorbed by another target to create neutrons [1]. Alternatively, one may use lenses to focus the neutrons to increase yield rather than simply generating more neutrons with more powerful lasers [2]. Assessing either approach requires a comprehensive model simulating neutron generation and transport to optimize the target material, system geometry, and neutron yield. A complete model from laser source to neutron generation is beyond the scope of the current study, so this project focuses on simulating the interaction of deuterons with typical target materials, such as lithium or beryllium. We use the neutron transport code Monte Carlo N-Particles (MCNP), which applies the Monte Carlo method to track particles [3]. The simulations accurately reflected experimental results from several groups [4]. Future analyses will assess improvements in neutron yield and directionality through strategically incorporating neutron lenses

Measurement of the CMS Magnetic Field

The measurement of the magnetic field in the tracking volume inside the superconducting coil of the Compact Muon Solenoid (CMS) detector under construction at CERN is done with a fieldmapper designed and produced at Fermilab. The fieldmapper uses 10 3-D B-sensors (Hall probes) developed at NIKHEF and calibrated at CERN to precision 0.05% for a nominal 4 T field. The precise fieldmapper measurements are done in 33840 points inside a cylinder of 1.724 m radius and 7 m long at central fields of 2, 3, 3.5, 3.8, and 4 T. Three components of the magnetic flux density at the CMS coil maximum excitation and the remanent fields on the steel-air interface after discharge of the coil are measured in check-points with 95 3-D B-sensors located near the magnetic flux return yoke elements. Voltages induced in 22 flux-loops made of 405-turn installed on selected segments of the yoke are sampled online during the entire fast discharge (190 s time-constant) of the CMS coil and integrated offline to provide a measurement of the initial magnetic flux density in steel at the maximum field to an accuracy of a few percent. The results of the measurements made at 4 T are reported and compared with a three-dimensional model of the CMS magnet system calculated with TOSCA.Comment: 4 pages, 5 figures, 15 reference

UKGEOS: Glasgow Geothermal Energy Research Field Site (GGERFS): initial summary of the geological platform

The preferred second UKGEOS site is at Clyde Gateway, in the east end of Glasgow, Scotland. The focus of this, the Glasgow Geothermal Energy Research Field Site (GGERFS), is on characterising and monitoring the subsurface for minewater and hot sedimentary aquifer geothermal energy, and for cooling and heat storage. This report details BGS data and knowledge at late 2016, to define initial characterisation of the ‘geological platform’ relevant for the planning of a geothermal research facility and associated environmental baseline monitoring. The report covers knowledge of the bedrock and superficial deposits geology, abandoned coal mines, hydrogeology, geothermal datasets, geochemistry, remote sensed data, seismicity, stress fields, engineering geology and rock property datasets. BGS holds a great deal of legacy borehole, mining and geochemistry data and has updated existing bedrock and superficial deposits models of the area. However, deep borehole and seismic data are lacking to define the geology and structure of the area below a few hundred metres. Hydrogeological and temperature data are also lacking for the bedrock strata. Regional datasets and knowledge have (and can be further) used to reduce uncertainty and risk in these aspects of the geological characterisation

Development and Testing of a Vehicle Management System for Autonomous Spacecraft Habitat Operations

As the increased distance between Earth-based mission control and the spacecraft results in increasing communication delays, small crews cannot take on all functions performed by ground today, and so vehicles must be more automated to reduce the crew workload for such missions. In addition, both near-term and future missions will feature significant periods when crew is not present, meaning the vehicles will need to operate themselves autonomously. NASA's Advanced Exploration Systems Program pioneers new approaches for rapidly developing prototype systems, demonstrating key capabilities, and validating operational concepts for future human missions beyond low-Earth orbit. Under this program, NASA has developed and demonstrated multiple technologies to enable the autonomous operation of a dormant space habitat. These technologies included a fault-tolerant avionics architecture, novel spacecraft power system and power system controller, and autonomy software to control the habitat. The demonstration involved simulation of the habitat and multiple spacecraft sub-systems (power storage and distribution, avionics, and air-side life-support) during a multi-day test at NASA's Johnson Space Center. The foundation of the demonstration was quiescent operations' of a habitat during a 55 minute eclipse period. For this demonstration, the spacecraft power distribution system and air-side life support system were simulated at a high level of fidelity; additional systems were managed, but with lower fidelity operational constraints and system behavior. Operational constraints for real and simulated loads were developed by analyzing on-orbit hardware and evaluating future Exploration capable technology. A total of 13 real and simulated loads were used during the test. Eight scenarios including both nominal and off-nominal conditions were performed. Over the course of the test, every application performed its desired functions successfully during the simulated tests. The results will inform both future tests, as well as provide insight to NASA's domestic and international partners, as they construct the next generation of space habitats to be used on beyond-Earth missions

High School Exit Examinations: When Do Learning Effects Generalize?

This paper reviews international and domestic evidence on the effects of three types of high school exit exam systems: voluntary curriculum-based external exit exams, universal curriculum-based external exit exam systems and minimum competency tests that must be passed to receive a regular high school diploma. The nations and provinces that use Universal CBEEES (and typically teacher grades as well) to signal student achievement have significantly higher achievement levels and smaller differentials by family background than otherwise comparable jurisdictions that base high stakes decisions on voluntary college admissions tests and/or teacher grades. The introduction of Universal CBEEES in New York and North Carolina during the 1990s was associated with large increases in math achievement on NAEP tests. Research on MCTs and high school accountability tests is less conclusive because these systems are new and have only been implemented in one country. Cross-section studies using a comprehensive set of controls for family background have not found that students in MCT states score higher on audit tests like the NAEP that carry no stakes for the test taker. The analysis reported in table 1 tells us that the five states that introduced MCTs during the 1990s had significantly larger improvements on NAEP tests than states that made no change in their student accountability regime. The gains, however, are smaller than for the states introducing Universal CBEEES. New York and North Carolina. The most positive finding about MCTs is that students in MCT states earn significantly more during the first eight years after graduation than comparable students in other states suggesting that MCTs improve employer perceptions of the quality of the recent graduates of local high schools

A Search for Dark Higgs Bosons

Recent astrophysical and terrestrial experiments have motivated the proposal of a dark sector with GeV-scale gauge boson force carriers and new Higgs bosons. We present a search for a dark Higgs boson using 516 fb-1 of data collected with the BABAR detector. We do not observe a significant signal and we set 90% confidence level upper limits on the product of the Standard Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots for b/w printin

Detecting and predicting neutralization of alemtuzumab responses in MS

Objective: To test the hypothesis that anti-drug antibodies against alemtuzumab could become relevant after repeated treatments for some individuals, possibly explaining occasional treatment resistance. Methods: Recombinant alemtuzumab single-chain variable fragment antibody with a dual tandem nanoluciferase reporter linker was made and used to detect binding anti-drug antibodies. Alemtuzumab IgG Alexa-Fluor 488 conjugate was used in a competitive-binding cell based assay to detect neutralizing anti-drug antibodies. The assays were used to retrospectively screen, blinded, banked-serum samples from people with multiple sclerosis (n=32) who had received three or more cycles of alemtuzumab. Lymphocyte depletion was measured between baseline and about 1 month post-infusion. Results: The number of individuals showing limited depletion of lymphocytes increased with the number of treatment cycles. Lack of depletion was also a poor prognostic feature for future disease activity. Anti-drug antibody responses were detected in 29/32 (90.6%) individuals. Neutralizing antibodies occurred prior to the development of limited depletion in 6/7 individuals (18.8% of the whole sample). Pre-infusion, anti-drug antibody levels predicted limited, post-infusion lymphocyte depletion. Conclusions: Although anti-drug antibodies to alemtuzumab have been portrayed as being of no clinical significance, alemtuzumab-specific antibodies appear to be clinically relevant for some individuals, although causation remains to be established. Monitoring of, lymphocyte depletion and the anti-drug response may be of practical value in patients requiring additional cycles of alemtuzumab. Anti-drug antibody detection may help to inform on re-treatment or switching to another treatment