Trap-Assisted Tunneling in the Schottky Barrier

The paper presents a new way how to calculate the currents in a Schottky barrier. The novel phenomeno-logical model extends the Shockley-Read-Hall recombi-nation-generation theory of trap-assisted tunneling. The proposed approach explains the occurrence of large leakage currents in Schottky structures on wide band semi-conductors with a high Schottky barrier (above 1 eV) and with a high density of traps. Under certain conditions, trap-assisted tunneling (TAT) plays a more important role than direct tunneling

Threat modeling for communication security of IoT-enabled digital logistics

The modernization of logistics through the use of Wireless Sensor Network (WSN) Internet of Things (IoT) devices promises great efficiencies. Sensor devices can provide real-time or near real-time condition monitoring and location tracking of assets during the shipping process, helping to detect delays, prevent loss, and stop fraud. However, the integration of low-cost WSN/IoT systems into a pre-existing industry should first consider security within the context of the application environment. In the case of logistics, the sensors are mobile, unreachable during the deployment, and accessible in potentially uncontrolled environments. The risks to the sensors include physical damage, either malicious/intentional or unintentional due to accident or the environment, or physical attack on a sensor, or remote communication attack. The easiest attack against any sensor is against its communication. The use of IoT sensors for logistics involves the deployment conditions of mobility, inaccesibility, and uncontrolled environments. Any threat analysis needs to take these factors into consideration. This paper presents a threat model focused on an IoT-enabled asset tracking/monitoring system for smart logistics. A review of the current literature shows that no current IoT threat model highlights logistics-specific IoT security threats for the shipping of critical assets. A general tracking/monitoring system architecture is presented that describes the roles of the components. A logistics-specific threat model that considers the operational challenges of sensors used in logistics, both malicious and non-malicious threats, is then given. The threat model categorizes each threat and suggests a potential countermeasure

Dataset: LoED: The LoRaWAN at the Edge dataset

This paper presents the LoRaWAN at the Edge Dataset (LoED), an open LoRaWAN packet dataset collected at gateways. Real-world LoRaWAN datasets are important for repeatable sensor-network and communications research and evaluation as, if carefully collected, they provide realistic working assumptions. LoED data is collected from nine gateways over a four month period in a dense urban environment. The dataset contains packet header information and all physical layer properties reported by gateways such as the CRC, RSSI, SNR and spreading factor. Files are provided to analyse the data and get aggregated statistics. The dataset is available at: doi.org/10.5281/zenodo.412143

Formal verification of synchronisation, gossip and environmental effects for wireless sensor networks

The Internet of Things (IoT) promises a revolution in the monitoring and control of a wide range of applications, from urban water supply networks and precision agriculture food production, to vehicle connectivity and healthcare monitoring. For applications in such critical areas, control software and protocols for IoT systems must be verified to be both robust and reliable. Two of the largest obstacles to robustness and reliability in IoT systems are effects on the hardware caused by environmental conditions, and the choice of parameters used by the protocol. In this paper we use probabilistic model checking to verify that a synchronisation and dissemination protocol for Wireless Sensor Networks (WSNs) is correct with respect to its requirements, and is not adversely affected by the environment. We show how the protocol can be converted into a logical model and then analysed using the probabilistic model-checker, PRISM. Using this approach we prove under which circumstances the protocol is guaranteed to synchronise all nodes and disseminate new information to all nodes. We also examine the bounds on synchronisation as the environment changes the performance of the hardware clock, and investigate the scalability constraints of this approach. © 2019 Universitatsbibliothek TU Berlin

Taste activity in the parabrachial region in adult rats following neonatal chorda tympani transection

The chorda tympani is a gustatory nerve that fails to regenerate if sectioned in rats 10 days of age or younger. This early denervation causes an abnormally high preference for NH4Cl in adult rats, but the impact of neonatal chorda tympani transection on the development of the gustatory hindbrain is unclear. Here, we tested the effect of neonatal chorda tympani transection (CTX) on gustatory responses in the parabrachial nucleus (PbN). We recorded in vivo extracellular spikes in single PbN units of urethane-anesthetized adult rats following CTX at P5 (chronic CTX group) or immediately prior to recording (acute CTX group). Thus, all sampled PbN neurons received indirect input from taste nerves other than the CT. Compared to acute CTX rats, chronic CTX animals had significantly higher responses to stimulation with 0.1 and 0.5 M NH4Cl, 0.1 NaCl, and 0.01 M citric acid. Activity to 0.5 M sucrose and 0.01 M quinine stimulation was not significantly different between groups. Neurons from chronic CTX animals also had larger interstimulus correlations and significantly higher entropy, suggesting that neurons in this group were more likely to be activated by stimulation with multiple tastants. Although neural responses were higher in the PbN of chronic CTX rats compared to acute-sectioned controls, taste-evoked activity was much lower than observed in previous reports, suggesting permanent deficits in taste signaling. These findings demonstrate that the developing gustatory hindbrain exhibits high functional plasticity following early nerve injury

Hereditary spastic paraplegia in Greece: characterisation of a previously unexplored population using next-generation sequencing

Hereditary Spastic Paraplegia (HSP) is a syndrome characterised by lower limb spasticity, occurring alone or in association with other neurological manifestations, such as cognitive impairment, seizures, ataxia or neuropathy. HSP occurs worldwide, with different populations having different frequencies of causative genes. The Greek population has not yet been characterised. The purpose of this study was to describe the clinical presentation and molecular epidemiology of the largest cohort of HSP in Greece, comprising 54 patients from 40 families. We used a targeted next-generation sequencing (NGS) approach to genetically assess a proband from each family. We made a genetic diagnosis in >50% of cases and identified 11 novel variants. Variants in SPAST and KIF5A were the most common causes of autosomal dominant HSP, whereas SPG11 and CYP7B1 were the most common cause of autosomal recessive HSP. We identified a novel variant in SPG11, which led to disease with later onset and may be unique to the Greek population and report the first nonsense mutation in KIF5A. Interestingly, the frequency of HSP mutations in the Greek population, which is relatively isolated, was very similar to other European populations. We confirm that NGS approaches are an efficient diagnostic tool and should be employed early in the assessment of HSP patients

Treatment with 5-Fluorouracil and Celecoxib Displays Synergistic Regression of Ultraviolet Light B-Induced Skin Tumors

Standard chemotherapeutic agents used for the treatment of pre-cancerous skin lesions and non-melanoma skin cancers are not completely effective. Several studies have suggested that repeated inflammatory sunburn reactions, which include the induction of cyclooxygenase-2 (COX-2) and the subsequent production of prostaglandins, play a role in skin cancer development. COX-2 inhibition has been demonstrated to be a potent means of preventing skin cancer development in mice; however, COX-2 inhibitors alone are not effective as chemotherapeutic agents. Data in a variety of cancer types suggest greater efficacy in treating tumors with combination chemotherapies. Therefore, we hypothesized that a combination of the chemotherapeutic agent 5-fluorouracil (5-FU) and the COX-2 inhibitor and anti-inflammatory drug celecoxib would act synergistically to regress tumors in a murine model of ultraviolet light B- (UVB-) induced carcinogenesis. We found that topical treatment with 5-FU and celecoxib together was up to 70% more effective in reducing the number of UVB-induced skin tumors than 5-FU treatment alone. Our data suggest that more effective chemotherapy regimens can be developed to treat the millions of pre-cancerous and cancerous skin lesions that arise every year, which could ultimately lead to a significant reduction in costs and cosmetic defects (scarring) associated with surgical interventions

Ecosystem Consequences of Plant Genetic Divergence with Colonization of New Habitat

When plants colonize new habitats altered by natural or anthropogenic disturbances, those individuals may encounter biotic and abiotic conditions novel to the species, which can cause plant functional trait divergence. Over time, site-driven adaptation can give rise to population-level genetic variation, with consequences for plant community dynamics and ecosystem processes. We used a series of 3000-yr-old, lava-created forest fragments on the Island of Hawai`i to examine whether disturbance and subsequent colonization can lead to genetically differentiated populations, and where differentiation occurs, if there are ecosystem consequences of trait-driven changes. These fragments are dominated by a single tree species, Metrosideros polymorpha (Myrtaceae) or ʻohiʻa, which have been actively colonizing the surrounding lava flow created in 1858. To test our ideas about differentiation of genetically determined traits, we (1) created rooted cuttings of ʻohiʻa individuals sampled from fragment interiors and open lava sites, raised these individuals in a greenhouse, and then used these cuttings to create a common garden where plant growth was monitored for three years; and (2) assessed genetic variation and made QST/FST comparisons using microsatellite repeat markers. Results from the greenhouse showed quantitative trait divergence in plant height and pubescence across plants sampled from fragment interior and matrix sites. Results from the subsequent common garden study confirmed that the matrix environment can select for individuals with 9.1% less shoot production and 17.3% higher leaf pubescence. We found no difference in molecular genetic variation indicating gene flow among the populations. The strongest QST level was greater than the FST estimate, indicating sympatric genetic divergence in growth traits. Tree height was correlated with ecosystem properties such as soil carbon and nitrogen storage, soil carbon turnover rates, and soil phosphatase activity, indicating that selection for growth traits will influence structure, function, and dynamics of developing ecosystems. These data show that divergence can occur on centennial timescales of early colonization