Analysis of the Learjet 35/36 Wing and Correlation with Experimental Results

Two NASTRAN models of the Gates Learjet Corporation Model 35/36 Wing were developed. The models and the problems encountered in their development are discussed. A skin buckling analysis used for the ultimate loading conditions is presented. A discussion of the static tests and the correlation of the static test with the NASTRAN results and the results of a supplementary semimonocoque beam analysis are also included

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferative cells, including many cancer and stem cells, perform glycolysis robustly but limit fractional mitochondrial pyruvate oxidation. We sought to understand the role this transition from glycolysis to pyruvate oxidation plays in stem cell maintenance and differentiation. Loss of the MPC in Lgr5-EGFP-positive stem cells, or treatment of intestinal organoids with an MPC inhibitor, increases proliferation and expands the stem cell compartment. Similarly, genetic deletion of the MPC in Drosophila intestinal stem cells also increases proliferation, whereas MPC overexpression suppresses stem cell proliferation. These data demonstrate that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells

A Ship ‘for which Great Neptune Raves’: The Sovereign of the Seas, la Couronne and Seventeenth-Century International Competition over Warship Design

Charles I’s great warship the Sovereign of the Seas is famed for its design, decoration and importance as a tool that heightened the image of English naval supremacy. By exploring its career, size, name and decoration, this article highlights the Sovereign of the Seas’ significance as a national symbol of political and cultural power. It argues that Charles’s leading warship was developed as a reaction to naval advances and current affairs in Europe. Through a diverse range of evidence including diplomatic correspondence, printed texts and artwork from both English and French institutions, as well as relating this to similar advances in the Netherlands and Sweden, the Sovereign of the Seas’ development is internationally contextualized. By comparing it with other contemporary warships, most importantly la Couronne of France, it is shown that Charles’s flagship was a product of a growing international theatre of maritime activity that was inspired by cultural and political competition, as much as it was by military escalation

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic 2 reprogramming and mammary tumourigenesis

Dysregulation of histone modifications promotes carcinogenesis by altering transcription. Breast cancers frequently overexpress the histone methyltransferase EZH2, the catalytic subunit of Polycomb Repressor Complex 2 (PRC2). However, the role of EZH2 in this setting is unclear due to the context-dependent functions of PRC2 and the heterogeneity of breast cancer. Moreover, the mechanisms underlying PRC2 overexpression in cancer are obscure. Here, using multiple models of breast cancer driven by the oncogene ErbB2, we show that the tyrosine kinase c-Src links energy sufficiency with PRC2 overexpression via control of mRNA translation. By stimulating mitochondrial ATP production, c-Src suppresses energy stress, permitting sustained activation of the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), which increases the translation of mRNAs encoding the PRC2 subunits Ezh2 and Suz12. We show that Ezh2 overexpression and activity are pivotal in ErbB2-mediated mammary tumourigenesis. These results reveal the hitherto unknown c-Src/mTORC1/PRC2 axis, which is essential for ErbB2-driven carcinogenesis

The impact of Western beauty ideals on the lives of women and men: A sociocultural perspective

According to a recent survey of 3,300 girls and women across 10 countries, 90 per cent of all women aged 15 to 64 worldwide want to change at least one aspect of their physical appearance, with body weight ranking the highest (Etcoff, Orbach, Scott, & D’Agostino, 2004). This finding suggests that women’s anxiety about their appearance is a global phenomenon, observed in every country studied from Saudi Arabia to the United States. Beyond body dissatisfaction, a stunning 67 per cent of all women aged 15 to 64 worldwide reported that they actually withdraw from life-engaging, life-sustaining activities due to feeling badly about their looks. These activities include giving an opinion, meeting friends, exercising, going to work, going to school, dating, and going to the doctor

For richer - for poorer? Report of a conference on the Child Support Act 1992

Report of a conference held London (GB), 8 Oct 1992Available from British Library Document Supply Centre- DSC:OP-LG/7378 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo