176 research outputs found
Formation of regular spatial patterns in ratio-dependent predator-prey model driven by spatial colored-noise
Results are reported concerning the formation of spatial patterns in the
two-species ratio-dependent predator-prey model driven by spatial
colored-noise. The results show that there is a critical value with respect to
the intensity of spatial noise for this system when the parameters are in the
Turing space, above which the regular spatial patterns appear in two
dimensions, but under which there are not regular spatial patterns produced. In
particular, we investigate in two-dimensional space the formation of regular
spatial patterns with the spatial noise added in the side and the center of the
simulation domain, respectively.Comment: 4 pages and 3 figure
D-BAS - A dialog-based online argumentation system
In this paper, we present D-BAS, a dialog-based online argumentation system, tailored to support e-participation processes. The main idea of D-BAS is to let users exchange proposals and arguments with each other in the form of a timeshifted dialog where arguments are presented and acted upon one-at-a-time. We highlight the key research challenges that needed to be addressed in order to realize such a system, provide solutions for those challenges, report on a full scale implementation of D-BAS and summarize the findings from a real world e-participation process, where D-BAS provided the infrastructure for online argumentation
Effects of competition on pattern formation in the rock-paper-scissors game
We investigate the impact of cyclic competition on pattern formation in the
rock-paper-scissors game. By separately considering random and prepared initial
conditions, we observe a critical influence of the competition rate on the
stability of spiral waves and on the emergence of biodiversity. In particular,
while increasing values of promote biodiversity, they may act detrimental
on spatial pattern formation. For random initial conditions, we observe a phase
transition from biodiversity to an absorbing phase, whereby the critical value
of mobility grows linearly with increasing values of on a log-log scale,
but then saturates as becomes large. For prepared initial conditions, we
observe the formation of single-armed spirals, but only for values of that
are below a critical value. Once above, the spirals break up and form
disordered spatial structures, mainly because of the percolation of vacant
sites. Thus, there exists a critical value of the competition rate for
stable single-armed spirals in finite populations. Importantly though,
increases with increasing system size, because noise reinforces the
disintegration of ordered patterns. In addition, we also find that
increases with the mobility. These phenomena are reproduced by a deterministic
model that is based on nonlinear partial differential equations. Our findings
indicate that competition is vital for the sustenance of biodiversity and
emergence of pattern formation in ecosystems governed by cyclical interactions.Comment: 7 two-column pages, 7 figures; accepted for publication in Physical
Review
Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment.
Tyrosine kinase inhibitors represent today's treatment of choice in chronic myeloid leukemia (CML). Allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as salvage therapy. This prospective randomized CML-study IIIA recruited 669 patients with newly diagnosed CML between July 1997 and January 2004 from 143 centers. Of these, 427 patients were considered eligible for HSCT and were randomized by availability of a matched family donor between primary HSCT (group A; N=166 patients) and best available drug treatment (group B; N=261). Primary end point was long-term survival. Survival probabilities were not different between groups A and B (10-year survival: 0.76 (95% confidence interval (CI): 0.69-0.82) vs 0.69 (95% CI: 0.61-0.76)), but influenced by disease and transplant risk. Patients with a low transplant risk showed superior survival compared with patients with high- (P<0.001) and non-high-risk disease (P=0.047) in group B; after entering blast crisis, survival was not different with or without HSCT. Significantly more patients in group A were in molecular remission (56% vs 39%; P=0.005) and free of drug treatment (56% vs 6%; P<0.001). Differences in symptoms and Karnofsky score were not significant. In the era of tyrosine kinase inhibitors, HSCT remains a valid option when both disease and transplant risk are considered
Turing patterns on networks
Turing patterns formed by activator-inhibitor systems on networks are
considered. The linear stability analysis shows that the Turing instability
generally occurs when the inhibitor diffuses sufficiently faster than the
activator. Numerical simulations, using a prey-predator model on a scale-free
random network, demonstrate that the final, asymptotically reached Turing
patterns can be largely different from the critical modes at the onset of
instability, and multistability and hysteresis are typically observed. An
approximate mean-field theory of nonlinear Turing patterns on the networks is
constructed.Comment: 4 pages, 4 figure
Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease
BACKGROUND: Acute graft-versus-host disease (GVHD) remains a major limitation of allogeneic stem-cell transplantation; not all patients have a response to standard glucocorticoid treatment. In a phase 2 trial, ruxolitinib, a selective Janus kinase (JAK1 and JAK2) inhibitor, showed potential efficacy in patients with glucocorticoid-refractory acute GVHD. METHODS: We conducted a multicenter, randomized, open-label, phase 3 trial comparing the efficacy and safety of oral ruxolitinib (10 mg twice daily) with the investigator's choice of therapy from a list of nine commonly used options (control) in patients 12 years of age or older who had glucocorticoid-refractory acute GVHD after allogeneic stem-cell transplantation. The primary end point was overall response (complete response or partial response) at day 28. The key secondary end point was durable overall response at day 56. RESULTS: A total of 309 patients underwent randomization; 154 patients were assigned to the ruxolitinib group and 155 to the control group. Overall response at day 28 was higher in the ruxolitinib group than in the control group (62% [96 patients] vs. 39% [61]; odds ratio, 2.64; 95% confidence interval [CI], 1.65 to 4.22; P<0.001). Durable overall response at day 56 was higher in the ruxolitinib group than in the control group (40% [61 patients] vs. 22% [34]; odds ratio, 2.38; 95% CI, 1.43 to 3.94; P<0.001). The estimated cumulative incidence of loss of response at 6 months was 10% in the ruxolitinib group and 39% in the control group. The median failure-free survival was considerably longer with ruxolitinib than with control (5.0 months vs. 1.0 month; hazard ratio for relapse or progression of hematologic disease, non-relapse-related death, or addition of new systemic therapy for acute GVHD, 0.46; 95% CI, 0.35 to 0.60). The median overall survival was 11.1 months in the ruxolitinib group and 6.5 months in the control group (hazard ratio for death, 0.83; 95% CI, 0.60 to 1.15). The most common adverse events up to day 28 were thrombocytopenia (in 50 of 152 patients [33%] in the ruxolitinib group and 27 of 150 [18%] in the control group), anemia (in 46 [30%] and 42 [28%], respectively), and cytomegalovirus infection (in 39 [26%] and 31 [21%]). CONCLUSIONS: Ruxolitinib therapy led to significant improvements in efficacy outcomes, with a higher incidence of thrombocytopenia, the most frequent toxic effect, than that observed with control therapy
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