547 research outputs found
Active-Region Tilt Angles: Magnetic Versus White-Light Determinations of Joy's Law
The axes of solar active regions are inclined relative to the east--west
direction, with the tilt angle tending to increase with latitude ("Joy's law").
Observational determinations of Joy's law have been based either on white-light
images of sunspot groups or on magnetograms, where the latter have the
advantage of measuring directly the physically relevant quantity (the
photospheric field), but the disadvantage of having been recorded routinely
only since the mid-1960s. White-light studies employing the historical Mount
Wilson (MW) database have yielded tilt angles that are smaller and that
increase less steeply with latitude than those obtained from magnetic data. We
confirm this effect by comparing sunspot-group tilt angles from the Debrecen
Photoheliographic Database with measurements made by Li and Ulrich using MW
magnetograms taken during cycles 21--23. Whether white-light or magnetic data
are employed, the median tilt angles significantly exceed the mean values, and
provide a better characterization of the observed distributions. The
discrepancy between the white-light and magnetic results is found to have two
main sources. First, a substantial fraction of the white-light "tilt angles"
refer to sunspots of the same polarity. Of greater physical significance is
that the magnetograph measurements include the contribution of plage areas,
which are invisible in white-light images but tend to have greater axial
inclinations than the adjacent sunspots. Given the large uncertainties inherent
in both the white-light and the magnetic measurements, it remains unclear
whether any systematic relationship exists between tilt angle and cycle
amplitude during cycles 16--23.Comment: 35 pages, 13 figures, Accepted in Ap
State curves and flipping for an orbiting cylinder at low Reynolds numbers
Sudden changes found in the time-mean and rms values of forcecoefficients of a circular cylinder in forced orbital motion placed in a uniform stream when plotted against ellipticity of the orbital path suggest that two solutions(states) exist. This 2D numerical simulation was performed in order to gain furtherevidence of this hypothesis through flipping of the solution. Time histories and limit cycle curves of force coefficients for stationary, in-line, and orbital paths around the time of the flip were investigated, as well as time-mean and rms values of lift, drag, and base pressure coefficients versus ellipticity for the flipped solution. Results provide evidence of the existence of two solutions
Incorporating prior knowledge improves detection of differences in bacterial growth rate
BACKGROUND: Robust statistical detection of differences in the bacterial growth rate can be challenging, particularly when dealing with small differences or noisy data. The Bayesian approach provides a consistent framework for inferring model parameters and comparing hypotheses. The method captures the full uncertainty of parameter values, whilst making effective use of prior knowledge about a given system to improve estimation. RESULTS: We demonstrated the application of Bayesian analysis to bacterial growth curve comparison. Following extensive testing of the method, the analysis was applied to the large dataset of bacterial responses which are freely available at the web-resource, ComBase. Detection was found to be improved by using prior knowledge from clusters of previously analysed experimental results at similar environmental conditions. A comparison was also made to a more traditional statistical testing method, the F-test, and Bayesian analysis was found to perform more conclusively and to be capable of attributing significance to more subtle differences in growth rate. CONCLUSIONS: We have demonstrated that by making use of existing experimental knowledge, it is possible to significantly improve detection of differences in bacterial growth rate
Analysis of low Reynolds number flow around a heated circular cylinder
The objective of this study is to investigate the forced convection from and the flow around a heated cylinder. Experimental and computational results are presented for laminar flow around a heated circular cylinder with a diameter of 10 mm. The experiments were carried out using Particle Image Velocimetry (PIV) in a wind tunnel, and numerical simulations using an in-house code and a commercial software package, FLUENT. This paper pre-sents comparisons for vorticity and temperature contours in the wake of the cylinder. Experimental and computa-tional results are compared with those available in the literature for heated and unheated cylinders. An equation is suggested for a temperature-dependent coefficient defining a reference temperature to be used in place of the con-stant used in other studies. An attempt is also made to correct differences between average cylinder surface tem-perature and measured interior temperature of the cylinder
Solar Flare Intermittency and the Earth's Temperature Anomalies
We argue that earth's short-term temperature anomalies and the solar flare
intermittency are linked. The analysis is based upon the study of the scaling
of both the spreading and the entropy of the diffusion generated by the
fluctuations of the temperature time series. The joint use of these two methods
evidences the presence of a L\'{e}vy component in the temporal persistence of
the temperature data sets that corresponds to the one that would be induced by
the solar flare intermittency. The mean monthly temperature datasets cover the
period from 1856 to 2002.Comment: 4 pages, 5 figure
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The site of allergen expression in hematopoietic cells determines the degree and quality of tolerance induced through molecular chimerism
The transplantation of allergens (e.g. Phl p 5 or Bet v 1) expressed on BM cells as membrane-anchored full-length proteins leads to permanent tolerance at the T-cell, B-cell, and effector-cell levels. Since the exposure of complete allergens bears the risk of inducing anaphylaxis, we investigated here whether expression of Phl p 5 in the cytoplasm (rather than on the cell surface) is sufficient for tolerance induction. Transplantation of BALB/c BM retrovirally transduced to express Phl p 5 in the cytoplasm led to stable and durable molecular chimerism in syngeneic recipients (∼20% chimerism at 6 months). Chimeras showed allergen-specific T-cell hyporesponsiveness. Further, Phl p 5-specific TH1-dependent humoral responses were tolerized in several chimeras. Surprisingly, Phl p 5-specific IgE and IgG1 levels were significantly reduced but still detectable in sera of chimeric mice, indicating incomplete B-cell tolerance. No Phl p 5-specific sIgM developed in cytoplasmic chimeras, which is in marked contrast to mice transplanted with BM expressing membrane-anchored Phl p 5. Thus, the expression site of the allergen substantially influences the degree and quality of tolerance achieved with molecular chimerism in IgE-mediated allergy
Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRn
The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for presentation. We have previously shown that overexpression of FcRn in transgenic mice significantly improves the humoral immune response. Because rabbits are an important source of polyclonal and monoclonal antibodies, adaptation of our FcRn overexpression technology in this species would bring significant advantages. We cloned the full length cDNA of the rabbit FcRn alpha-chain and found that it is similar to its orthologous analyzed so far. The rabbit FcRn - IgG contact residues are highly conserved, and based on this we predicted pH dependent interaction, which we confirmed by analyzing the pH dependent binding of FcRn to rabbit IgG using yolk sac lysates of rabbit fetuses by Western blot. Using immunohistochemistry, we detected strong FcRn staining in the endodermal cells of the rabbit yolk sac membrane, while the placental trophoblast cells and amnion showed no FcRn staining. Then, using BAC transgenesis we generated transgenic rabbits carrying and overexpressing a 110 kb rabbit genomic fragment encoding the FcRn. These transgenic rabbits - having one extra copy of the FcRn when hemizygous and two extra copies when homozygous - showed improved IgG protection and an augmented humoral immune response when immunized with a variety of different antigens. Our results in these transgenic rabbits demonstrate an increased immune response, similar to what we described in mice, indicating that FcRn overexpression brings significant advantages for the production of polyclonal and monoclonal antibodies
Active-region Tilt Angles: Magnetic versus White-light Determinations of Joy's Law
The axes of solar active regions are inclined relative to the east-west direction, with the tilt angle tending to increase with latitude ("Joy's law"). Observational determinations of Joy's law have been based either on white-light images of sunspot groups or on magnetograms, where the latter have the advantage of measuring directly the physically relevant quantity (the photospheric field), but the disadvantage of having been recorded routinely only since the mid-1960s. White-light studies employing the historical Mount Wilson (MW) database have yielded tilt angles that are smaller and that increase less steeply with latitude than those obtained from magnetic data. We confirm this effect by comparing sunspot-group tilt angles from the Debrecen Photoheliographic Database with measurements made by Li and Ulrich using MW magnetograms taken during cycles 21-23. Whether white-light or magnetic data are employed, the median tilt angles significantly exceed the mean values, and provide a better characterization of the observed distributions. The discrepancy between the white-light and magnetic results is found to have two main sources. First, a substantial fraction of the white-light "tilt angles" refer to sunspots of the same polarity. Of greater physical significance is that the magnetograph measurements include the contribution of plage areas, which are invisible in white-light images but tend to have greater axial inclinations than the adjacent sunspots. Given the large uncertainties inherent in both the white-light and the magnetic measurements, it remains unclear whether any systematic relationship exists between tilt angle and cycle amplitude during cycles 16-23
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