Indicators of implicit and explicit social anxiety influence threat-related interpretive bias as a function of working memory capacity

Interpretive biases play a crucial role in anxiety disorders. The aim of the current study was to examine factors that determine the relative strength of threat-related interpretive biases that are characteristic of individuals high in social anxiety. Different (dual process) models argue that both implicit and explicit processes determine information processing biases and behavior, and that their impact is moderated by the availability of executive resources such as working memory capacity (WMC). Based on these models, we expected indicators of implicit social anxiety to predict threat-related interpretive bias in individuals low, but not high in WMC. Indicators of explicit social anxiety should predict threat-related interpretive bias in individuals high, but not low in WMC. As expected, WMC moderated the impact of implicit social anxiety on threat-related interpretive bias, although the simple slope for individuals low in WMC was not statistically significant. The hypotheses regarding explicit social anxiety (with fear of negative evaluation used as an indicator) were fully supported. The clinical implications of these findings are discussed

Subthreshold phi-meson production in heavy-ion collisions

Within a transport code of BUU type the production of phi-mesons in the reactions Ni+Ni at 1.93 AGeV and Ru+Ru at 1.69 AGeV is studied. New elementary reaction channels rho+N(Delta) to phi+N and pi+N(1520) to phi+N are included. In spite of a substantial increase of the \phi multiplicities by these channels the results stay below the tentative numbers extracted from experimental data.Comment: 17 pages(LaTeX), two new figures adde

Design of the Pluto Event Generator

We present the design of the simulation package Pluto, aimed at the study of hadronic interactions at SIS and FAIR energies. Its main mission is to offer a modular framework with an object-oriented structure, thereby making additions such as new particles, decays of resonances, new models up to modules for entire changes easily applicable. Overall consistency is ensured by a plugin- and distribution manager. Particular features are the support of a modular structure for physics process descriptions, and the possibility to access the particle stream for on-line modifications. Additional configuration and self-made classes can be attached by the user without re-compiling the package, which makes Pluto extremely configurable.Comment: Presented at the 17th International Conference on Computing in High Energy and Nuclear Physic

Design of the Pluto Event Generator

We present the design of the simulation package Pluto, aimed at the study of hadronic interactions at SIS and FAIR energies. Its main mission is to offer a modular framework with an object-oriented structure, thereby making additions such as new particles, decays of resonances, new models up to modules for entire changes easily applicable. Overall consistency is ensured by a plugin- and distribution manager. Particular features are the support of a modular structure for physics process descriptions, and the possibility to access the particle stream for on-line modifications. Additional configuration and self-made classes can be attached by the user without re-compiling the package, which makes Pluto extremely configurable.Comment: Presented at the 17th International Conference on Computing in High Energy and Nuclear Physic

Design of the Pluto Event Generator

We present the design of the simulation package Pluto, aimed at the study of hadronic interactions at SIS and FAIR energies. Its main mission is to offer a modular framework with an object-oriented structure, thereby making additions such as new particles, decays of resonances, new models up to modules for entire changes easily applicable. Overall consistency is ensured by a plugin- and distribution manager. Particular features are the support of a modular structure for physics process descriptions, and the possibility to access the particle stream for on-line modifications. Additional configuration and self-made classes can be attached by the user without re-compiling the package, which makes Pluto extremely configurable.Comment: Presented at the 17th International Conference on Computing in High Energy and Nuclear Physic

IL-21 and IL-21 Receptor Expression in Lymphocytes and Neurons in Multiple Sclerosis Brain

IL-17–producing CD4+ T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17–polarizing conditions (IL-6 and transforming growth factor-β). In this study we investigated IL-21 and IL-21 receptor (IL-21R) expression in MS lesions by in situ hybridization and immunohistochemistry. We detected strongly IL-21+ infiltrating cells predominantly in acute but also in chronic active white matter MS lesions in which IL-21 expression was restricted to CD4+ cells. In contrast, IL-21R was much more broadly distributed on CD4+, CD19+, and CD8+ lymphocytes but not major histocompatibility complex class-II+ macrophages/microglia. Interestingly, in cortical areas we detected both IL-21 and IL-21R expression by neurons. These findings suggest role(s) for IL-21 in both the acute and chronic stages of MS via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons

An optically actuated surface scanning probe

We demonstrate the use of an extended, optically trapped probe that is capable of imaging surface topography with nanometre precision, whilst applying ultra-low, femto-Newton sized forces. This degree of precision and sensitivity is acquired through three distinct strategies. First, the probe itself is shaped in such a way as to soften the trap along the sensing axis and stiffen it in transverse directions. Next, these characteristics are enhanced by selectively position clamping independent motions of the probe. Finally, force clamping is used to refine the surface contact response. Detailed analyses are presented for each of these mechanisms. To test our sensor, we scan it laterally over a calibration sample consisting of a series of graduated steps, and demonstrate a height resolution of ∼ 11 nm. Using equipartition theory, we estimate that an average force of only ∼ 140 fN is exerted on the sample during the scan, making this technique ideal for the investigation of delicate biological samples

Hospital nurse staffing: Choice of measure matters

BACKGROUND: Researchers frequently use nurse staffing measures to examine hospital quality of care. Measure choices include nurse-reported perception of staffing adequacy, nurse-reported patient workloads, and empirically derived hours per patient day (HPPD). OBJECTIVE: To examine the correlations across these measures and identify factors associated with these staffing measures. DESIGN, SETTINGS, AND SUBJECTS: A cross-sectional correlational study of 92 medical-surgical, rehabilitation, and intermediate in 11 acute care hospitals was carried out. METHODS: We surveyed registered nurses on their perceived staffing adequacy, last shift patient workload, and unit-level structures and processes of care delivery. Individual responses to these measures were aggregated to the nursing unit level, and unit-level HPPD, unit-level case mix index were obtained from each hospital's administrative data. After examining the correlation matrix across variables, those associated with the 3 staffing measures were then examined using linear regression. RESULTS: HPPD and the nurse-reported patient workload on last shift were correlated (r=-0.276, P=0.008), and perceptions of the adequacy of staffing and nurse-reported patient workload on last shift were correlated (r=-0.384, P=0.000). In multivariable analyses, inadequate numbers of assistive personnel was significantly associated with both perceived staffing adequacy and nurse-reported patient loads. Unit-level case mix index was significantly associated with both HPPD and nurse-reported patient loads. These data suggest that the 3 measures of nurse staffing are not highly correlated, and may capture different elements of the unit context to explain nurse staffing. Researchers should consider the correlates of these measures when selecting nurse staffing measures for future investigations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94113/1/Hospital nurse staffing Choice of measure matters.pd