Long-term clinical results of autologous bone marrow CD 133+ cell transplantation in patients with ST-elevation myocardial infarction

The aim of the study was investigate the long-term results of autologous bone marrow CD 133+ cell transplantation in patients with primary ST-Elevation Myocardial Infarction (STEMI). Methods and results: From 2006 to 2007, 26 patients with primary STEMI were included in an open randomized study. Patients were randomized to two groups: 1st - included patients underwent PCI and transplantation of autologous bone marrow CD 133+ cell (n = 10); 2nd - patients with only PCI (n = 16). Follow-up study was performed 7.70±0.42 years after STEMI and consisted in physical examination, 6-min walking test, Echo exam. Total and cardiovascular mortality in group 1 was lower (20% (n = 2) vs. 44% (n = 7), p = 0.1 and 22% (n = 2) vs. 25% (n = 4), (p=0.53), respectively). Analysis of cardiac volumetric parameters shows significant differences between groups: EDV of 100.7 ± 50.2 mL vs. 144.40±42.7 mL, ESV of 56.3 ± 37.8 mL vs. 89.7 ± 38.7 mL in 1st and 2nd groups, respectively. Data of the study showed positive effects of autologous bone marrow CD 133+ cell transplantation on the long-term survival of patients and structural status of the heart

A global experiment on motivating social distancing during the COVID-19 pandemic

Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges

A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic

The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world

A global experiment on motivating social distancing during the COVID-19 pandemic

Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e. a controlling message) compared to no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly-internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared to the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly-internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing: Controlled motivation was associated with more defiance and less long-term behavioral intentions to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges

A global experiment on motivating social distancing during the COVID-19 pandemic

Significance Communicating in ways that motivate engagement in social distancing remains a critical global public health priority during the COVID-19 pandemic. This study tested motivational qualities of messages about social distancing (those that promoted choice and agency vs. those that were forceful and shaming) in 25,718 people in 89 countries. The autonomy-supportive message decreased feelings of defying social distancing recommendations relative to the controlling message, and the controlling message increased controlled motivation, a less effective form of motivation, relative to no message. Message type did not impact intentions to socially distance, but people’s existing motivations were related to intentions. Findings were generalizable across a geographically diverse sample and may inform public health communication strategies in this and future global health emergencies. Abstract Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges

HEART-TYPE FATTY ACID BINDING PROTEIN-BASED ExPRESS TEST IN THE DIAGNOSTICS OF ACUTE MYOCARDIAL INFARCTION

Aim. To compare the effectiveness of two express tests — CardioFABP andTroponin I WB-Check-1 in the diagnostics of acute myocardial infarction (AMI).Material and methods. The study included 38 patients who were hospitalised with the acute coronary syndrome (ACS) diagnosis within the first 12 hours after the painonset. At the admission, the peripheral blood levels of CK-MB and troponin I werequalitatively assessed using the immunochemiluminescent analyser “Access-2”(Beckman Coulter, USA). In addition, the express test Troponin I WB-Check-1(VEDALAB, France; sensitivity 1 ng/ml) was used. Qualitative assessment of hearttypefatty acid binding protein (hFABP) was performed with the express test“CardioFABP” (Biotest, Russia; sensitivity 15 ng/ml). For all tests, diagnosticsensitivity, diagnostic specificity, positive and negative predictive value, anddiagnostic effectiveness were assessed.Results. The express tests for hFABP and troponin I demonstrated high positivepredictive value and diagnostic specificity (100%). However, both tests also had falsenegative results, and, therefore, negative predictive value was low for both the hFABPtest (23,5%) and the troponin I test (17,4%). Diagnostic sensitivity was 35,4% for the troponin I express test and 57,6% for the hFABP express test. Diagnostic effectiveness was higher for the hFABP express test (62,2%). All positive results of the hFABPexpress test were confirmed by the other tests, which resulted in high positive predictive value (100%) and high diagnostic specificity (100%). In patients within the first 6 hours of ACS, diagnostic sensitivity of the hFABP express test was significantlyhigher than in those with a longer ACS duration (83,3% vs. 42,8%, respectively).Conclusion. The higher diagnostic sensitivity and diagnostic effectiveness of thehFABP-based express test in the first 6 hours of ACS, compared to a qualitativeassessment of troponin I and a later assessment of hFABP, agrees with the earlierobtained data and confirms the status of hFABP as the earliest marker of myocardialnecrosis

LONG TERM CLINICAL RESULTS OF AUTOLOGOUS CD133+ BONE MARROW CELLS TRANSPLANTATION IN ST ELEVATION MYOCARDIAL INFARCTION PATIENTS

Aim. To study the long-term effectiveness and safety of CD133+ bone marrow cells transplantation in ST elevation myocardial infarction (STEMI) patients.Material and methods. To the open-label, randomized study we included 26 patients, admitted with primary MI during years 2006-2007 to SRI of Cardiology. Patients were randomized to two groups: 1st — stenting of infarction-related coronary artery (IRA) and transplantation of CD133+ bone marrow cells (n=10), 2nd — only stenting of IRA (n=16). Baseline clinical and anamnestic parameters were similar. In 7,70±0,42 years after MI we performed control investigation, that included physical examination, 6-minute walking test (6WT), echocardiography.Results. It is found, that in the 1st group comparing to the 2nd, total and cardiovasular mortality was lower (20% (2) vs 44% (7), p=0,11; 22% (2) vs 25% (4), p=0,58, resp.). In the 2nd there were 7 cases of recurrent MI (44% of patients), 4 of those were fatal, but in the 1st group there were no any recurrent MI (p=0,01). During the whole followup, unstable angina was more common in the 2nd group (11 (69%) vs 2 (20%) in 1st, р=0,04). CHF of II FC and higher was more common in 2nd group: 8 (50%) vs 2 (20%) in 1st, р=0,07. Also, there were significant differences in analysis of volumetrics of the left ventricle (EDV — 100,7±50,2 mL vs 144,4±42,7 mL, р=0,049; ESV — 56,3±37,8 mL vs 89,7±38,7 mL, р=0,049, resp.). These values were lower in the 1st group.Conclusion. The results demonstrated that transplantation of autologous CD133+ bone marrow cells positively influences long-term survival of patients, CHD course and volumetric LV parameters

Assessment of the effect of cardiac rhythm and conduction disorders on the course and outcome of pregnancy: data of the Arrhythmia Center

Aim. To assess the effect of cardiac rhythm and conduction disorders on the course and outcome of pregnancy against the background of treatment.Material and methods. We analyzed 44 case histories of pregnant women examined in the department of surgical treatment of severe cardiac rhythm and conduction disorders during the period from 2012 to 2017 The patients’ age averaged 31,2±5,04 years. The survey was conducted during pregnancy from 12 to 37 weeks (average 28,0±6,4).Results. In most cases, rhythm disorders had idiopathic nature (57%), and in the remaining patients, diseases of the cardiovascular system were verified. Rhythm disorders before pregnancy were reported in 33 (75%) women. In two cases, ventricular tachycardia was hemodynamically significant. Therefore radiofrequency ablation was performed on 26 and 27 weeks of pregnancy. Radiofrequency ablation of supraventricular tachycardia was performed in three patients at the 27th, 29th and 31st week of pregnancy. One patient had an implanted pacemaker due to an atrioventricular block.Conclusion. Rhythm disorders observed in the patients did not require termination of the pregnancy. Antiarrhythmic therapy, prescribed for symptomatic, hemody-namically significant and life-threatening disorders, and surgical treatment made it possible to effectively manage pregnant women before delivery. Most patients had delivery on time, rhythm disorders in labor were not observed. Newborns had high Apgar scores

Long-term clinical results of autologous bone marrow CD 133+ cell transplantation in patients with ST-elevation myocardial infarction

The aim of the study was investigate the long-term results of autologous bone marrow CD 133+ cell transplantation in patients with primary ST-Elevation Myocardial Infarction (STEMI). Methods and results: From 2006 to 2007, 26 patients with primary STEMI were included in an open randomized study. Patients were randomized to two groups: 1st - included patients underwent PCI and transplantation of autologous bone marrow CD 133+ cell (n = 10); 2nd - patients with only PCI (n = 16). Follow-up study was performed 7.70±0.42 years after STEMI and consisted in physical examination, 6-min walking test, Echo exam. Total and cardiovascular mortality in group 1 was lower (20% (n = 2) vs. 44% (n = 7), p = 0.1 and 22% (n = 2) vs. 25% (n = 4), (p=0.53), respectively). Analysis of cardiac volumetric parameters shows significant differences between groups: EDV of 100.7 ± 50.2 mL vs. 144.40±42.7 mL, ESV of 56.3 ± 37.8 mL vs. 89.7 ± 38.7 mL in 1st and 2nd groups, respectively. Data of the study showed positive effects of autologous bone marrow CD 133+ cell transplantation on the long-term survival of patients and structural status of the heart