61 research outputs found
Food habits, Life style, Genetic background in tumour initiation and progression of Reproductive system
The relationship between diet and health is really engaging, it has been showed that modifications in dietary intake and the benefits of the Mediterranean diet, can importantly increase life expectancy, reducing the risk of chronic disease and improve quality of life. In this way, several studies assigned a highest reduction in tumor incidence to monosaturated and saturated lipids present in vegetables, such olive oil. On these basis, this study will be focused on the comprehension and understanding of initiation and progression phases linked to environmental stressors and food habits in the tumours of the reproductive system (breast and ovarian cancer). Recently it has been described the potential effect of the olive tree (Olea europaea) leaves, oil and fruits to inhibit proliferation and to induce apoptosis in different cancer cell lines. The phenolic fraction of Olive extract becomes specially interesting, including a polyphenol called Oleuropein (OL) present at higher levels in olives and leaves- as well as its hydrolysis metabolite, Hydroxytyrosol (HT). Taking this background into account, we have focused our research in the analysis of Olive leaf extracts with a high content in OL (48%) as a potential cell viability reducing agent on a malignant triple negative breast
cancer cell line, MDA-MB- 231, which is highly aggressive. On this model, cell viability was measured with a MTS assay 24 and 48 h after the treatment with the Olive extract. The preliminary results seem to indicate that this extract at high concentrations (200-400”g/mL) determines a reduction in the MDA- MB-231 cell viability
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Design and Characterization of a Prototype Stripline Beam Position Monitor for the Clic Drive Beam*
The prototype of a stripline Beam Position Monitor (BPM) with its associated readout electronics is under development at CERN, in collaboration with SLAC, LAPP and IFIC. The anticipated position resolution and accuracy are expected to be below 2ÎŒm and 20ÎŒm respectively for operation of the BPM in the CLIC drive beam (DB) linac. This paper describes the particular CLIC DB conditions with respect to the beam position monitoring, presents the measurement concept, and summarizes electromagnetic simulations and RF measurements performed on the prototype
RĂŽles,impacts et services issus des Ă©levages en Europe. SynthĂšse du rapport dâexpertise scientifique collective
LâĂ©levage, secteur majeur pour lâĂ©conomie de nombreux territoires et structurant beaucoup de paysages ruraux europĂ©ens, fait lâobjet de controverses, depuis au moins une dĂ©cennie, notamment du fait des dommages environnementaux quâil engendre. Dans un tel contexte, il est apparu nĂ©cessaire dâĂ©tayer les dĂ©bats en faisant le point sur lâĂ©tat des connaissances scientifiques relatives aux rĂŽles, impacts et services environnementaux, Ă©conomiques et sociaux issus des Ă©levages europĂ©ens et leurs produits. Pour ce faire, les ministĂšres français en charge de lâEnvironnement et de lâAgriculture ainsi que lâAgence de lâenvironnement et de la maĂźtrise de lâĂ©nergie (Ademe) ont sollicitĂ© lâInra pour rĂ©aliser une expertise scientifique collective (ESCo) abordant conjointement les multiples consĂ©quences sur les milieux et le climat, lâemploi et le travail, les marchĂ©s et certains enjeux sociaux et culturels, de la production et de la consommation humaine de produits dâorigine animale (bovins, ovins, caprins, porcins et avicoles). Lâanalyse de ces diverses dimensions sâappuie sur les dĂ©marches dâĂ©valuation rapportĂ©es dans la littĂ©rature scientifique internationale. AbordĂ©es, dans un premier temps, de maniĂšre analytique et globale, les connaissances ont ensuite Ă©tĂ© mobilisĂ©es par « bouquet de services » au sein de territoires contrastĂ©s. Les relations entre les diffĂ©rents impacts ou services permettent dâidentifier des compromis et des leviers dâaction envisageables pour les systĂšmes dâĂ©levage.
Livestock production is a sector of major economic importance that defines many European rural areas. It has become the focus of controversy over the past decade or more, particularly with regard to the environmental impacts it causes. In this context, it seemed useful to support this debate with a critical review of the state of scientific knowledge on the role, impacts, and services â environmental, economic, and social â associated with European livestock production. Accordingly, the French ministries responsible for Agriculture and the Environment, in cooperation with the French Environment and Energy Management Agency (ADEME), requested INRA to undertake a collective scientific assessment addressing the many consequences â for the environment and the climate, for employment and labor, for markets, and for a variety of social and cultural issues â related to the production and human consumption of animal products (cattle, sheep, goats, pigs, and poultry). Analysis of these diverse dimensions was based on assessment methods utilized and described in the international scientific literature. Using a broad, analytical overview as a starting point, the review proceeded by identifying the "service bundles" associated with livestock production in contrasting areas
The Compact Linear Collider (CLIC) - 2018 Summary Report
The Compact Linear Collider (CLIC) is a TeV-scale high-luminosity linear collider under development at CERN. Following the CLIC conceptual design published in 2012, this report provides an overview of the CLIC project, its current status, and future developments. It presents the CLIC physics potential and reports on design, technology, and implementation aspects of the accelerator and the detector. CLIC is foreseen to be built and operated in stages, at centre-of-mass energies of 380 GeV, 1.5 TeV and 3 TeV, respectively. CLIC uses a two-beam acceleration scheme, in which 12 GHz accelerating structures are powered via a high-current drive beam. For the first stage, an alternative with X-band klystron powering is also considered. CLIC accelerator optimisation, technical developments and system tests have resulted in an increased energy efficiency (power around 170 MW) for the 380 GeV stage, together with a reduced cost estimate at the level of 6 billion CHF. The detector concept has been refined using improved software tools. Significant progress has been made on detector technology developments for the tracking and calorimetry systems. A wide range of CLIC physics studies has been conducted, both through full detector simulations and parametric studies, together providing a broad overview of the CLIC physics potential. Each of the three energy stages adds cornerstones of the full CLIC physics programme, such as Higgs width and couplings, top-quark properties, Higgs self-coupling, direct searches, and many precision electroweak measurements. The interpretation of the combined results gives crucial and accurate insight into new physics, largely complementary to LHC and HL-LHC. The construction of the first CLIC energy stage could start by 2026. First beams would be available by 2035, marking the beginning of a broad CLIC physics programme spanning 25-30 years
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Design and Characterization of a Prototype Stripline Beam Position Monitor for the Clic Drive Beam*
Status of the Stripline Beam Position Monitor developement for the CLIC Drive Beam
In collaboration with SLAC, LAPP and IFIC, a first prototype of a stripline Beam Position Monitor (BPM) for the CLIC Drive Beam and its associated readout electronics has been successfully tested in the CLIC Test Facility linac (CTF3) at CERN. In addition, a modified prototype with downstream terminated striplines is under development to improve the suppression of unwanted RF signal interference. This paper presents the results of the beam tests, and the most relevant aspects for the modified stripline BPM design and its expected improvements
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Characterization Tests of a Stripline Beam Position Monitor for the CLIC Drive Beam
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