2,132 research outputs found
Over-diagnosis of malaria is not a lost cause.
BACKGROUND: Recent studies have highlighted the over-diagnosis of malaria in clinical settings in Africa. This study assessed the impact of a training programme implemented as part of an intervention trial on diagnostic behaviour of clinicians in a rural district hospital in a low-moderate malaria transmission setting. METHODS: From the beginning of 2005, a randomized controlled trial (RCT) of intermittent preventive treatment for malaria in infants (IPTi) has been conducted at the study hospital. As part of the RCT, the study team offered laboratory quality assurance, and supervision and training of paediatric ward staff using information on malaria epidemiology in the community. Data on clinical and blood slide confirmed cases of malaria from 2001 to 2005 were extracted from the hospital records. RESULTS: The proportion of blood slides positive for malaria parasites had decreased from 21% in 2001 to 7% in 2005 (p < .01). The proportion of outpatient and inpatient cases diagnosed as malaria ranged between 34% and 28% from 2001 to 2004 and this decreased substantially to 17% after the introduction of the package of training and support in 2005 (p < .01). There was no clear trend in the ratio of blood slide examined versus total diagnosis of malaria. CONCLUSION: It may be possible to change the diagnostic behaviour of clinicians by rigorous training using local malaria epidemiology data and supportive supervision
Creation of Entanglement by Interaction with a Common Heat Bath
I show that entanglement between two qubits can be generated if the two
qubits interact with a common heat bath in thermal equilibrium, but do not
interact directly with each other. In most situations the entanglement is
created for a very short time after the interaction with the heat bath is
switched on, but depending on system, coupling, and heat bath, the entanglement
may persist for arbitrarily long times. This mechanism sheds new light on the
creation of entanglement. A particular example of two quantum dots in a closed
cavity is discussed, where the heat bath is given by the blackbody radiation.Comment: 4 revtex pages, 1 eps figure; replaced with published version; short
discussion on entanglement distillation adde
Approximating Tverberg Points in Linear Time for Any Fixed Dimension
Let P be a d-dimensional n-point set. A Tverberg-partition of P is a
partition of P into r sets P_1, ..., P_r such that the convex hulls conv(P_1),
..., conv(P_r) have non-empty intersection. A point in the intersection of the
conv(P_i)'s is called a Tverberg point of depth r for P. A classic result by
Tverberg implies that there always exists a Tverberg partition of size n/(d+1),
but it is not known how to find such a partition in polynomial time. Therefore,
approximate solutions are of interest.
We describe a deterministic algorithm that finds a Tverberg partition of size
n/4(d+1)^3 in time d^{O(log d)} n. This means that for every fixed dimension we
can compute an approximate Tverberg point (and hence also an approximate
centerpoint) in linear time. Our algorithm is obtained by combining a novel
lifting approach with a recent result by Miller and Sheehy (2010).Comment: 14 pages, 2 figures. A preliminary version appeared in SoCG 2012.
This version removes an incorrect example at the end of Section 3.
Towards an optimal design of target for tsetse control: comparisons of novel targets for the control of palpalis group tsetse in West Africa
Background: Tsetse flies of the Palpalis group are the main vectors of sleeping sickness in Africa. Insecticide impregnated targets are one of the most effective tools for control. However, the cost of these devices still represents a constraint to their wider use. The objective was therefore to improve the cost effectiveness of currently used devices.
Methodology/Principal Findings: Experiments were performed on three tsetse species, namely Glossina palpalis gambiensis and G. tachinoides in Burkina Faso and G. p. palpalis in CĂ´te d'Ivoire. The 1Ă—1 m2 black blue black target commonly used in W. Africa was used as the standard, and effects of changes in target size, shape, and the use of netting instead of black cloth were measured. Regarding overall target shape, we observed that horizontal targets (i.e. wider than they were high) killed 1.6-5x more G. p. gambiensis and G. tachinoides than vertical ones (i.e. higher than they were wide) (P<0.001). For the three tsetse species including G. p. palpalis, catches were highly correlated with the size of the target. However, beyond the size of 0.75 m, there was no increase in catches. Replacing the black cloth of the target by netting was the most cost efficient for all three species.
Conclusion/Significance: Reducing the size of the current 1*1 m black-blue-black target to horizontal designs of around 50 cm and replacing black cloth by netting will improve cost effectiveness six-fold for both G. p. gambiensis and G. tachinoides. Studying the visual responses of tsetse to different designs of target has allowed us to design more cost-effective devices for the effective control of sleeping sickness and animal trypanosomiasis in Africa
Saturated Hydraulic Conductivity and Land Use Change, New Insights to the Payments for Ecosystem Services Programs: a Case Study from a Tropical Montane Cloud Forest Watershed in Eastern Central Mexico
Memory consolidation in the cerebellar cortex
Several forms of learning, including classical conditioning of the eyeblink, depend upon the cerebellum. In examining mechanisms of eyeblink conditioning in rabbits, reversible inactivations of the control circuitry have begun to dissociate aspects of cerebellar cortical and nuclear function in memory consolidation. It was previously shown that post-training cerebellar cortical, but not nuclear, inactivations with the GABA(A) agonist muscimol prevented consolidation but these findings left open the question as to how final memory storage was partitioned across cortical and nuclear levels. Memory consolidation might be essentially cortical and directly disturbed by actions of the muscimol, or it might be nuclear, and sensitive to the raised excitability of the nuclear neurons following the loss of cortical inhibition. To resolve this question, we simultaneously inactivated cerebellar cortical lobule HVI and the anterior interpositus nucleus of rabbits during the post-training period, so protecting the nuclei from disinhibitory effects of cortical inactivation. Consolidation was impaired by these simultaneous inactivations. Because direct application of muscimol to the nuclei alone has no impact upon consolidation, we can conclude that post-training, consolidation processes and memory storage for eyeblink conditioning have critical cerebellar cortical components. The findings are consistent with a recent model that suggests the distribution of learning-related plasticity across cortical and nuclear levels is task-dependent. There can be transfer to nuclear or brainstem levels for control of high-frequency responses but learning with lower frequency response components, such as in eyeblink conditioning, remains mainly dependent upon cortical memory storage
Phase separation due to quantum mechanical correlations
Can phase separation be induced by strong electron correlations? We present a
theorem that affirmatively answers this question in the Falicov-Kimball model
away from half-filling, for any dimension. In the ground state the itinerant
electrons are spatially separated from the classical particles.Comment: 4 pages, 1 figure. Note: text and figure unchanged, title was
misspelle
Seebeck Effect in Magnetic Tunnel Junctions
Creating temperature gradients in magnetic nanostructures has resulted in a
new research direction, i.e., the combination of magneto- and thermoelectric
effects. Here, we demonstrate the observation of one important effect of this
class: the magneto-Seebeck effect. It is observed when a magnetic configuration
changes the charge based Seebeck coefficient. In particular, the Seebeck
coefficient changes during the transition from a parallel to an antiparallel
magnetic configuration in a tunnel junction. In that respect, it is the analog
to the tunneling magnetoresistance. The Seebeck coefficients in parallel and
antiparallel configuration are in the order of the voltages known from the
charge-Seebeck effect. The size and sign of the effect can be controlled by the
composition of the electrodes' atomic layers adjacent to the barrier and the
temperature. Experimentally, we realized 8.8 % magneto-Seebeck effect, which
results from a voltage change of about -8.7 {\mu}V/K from the antiparallel to
the parallel direction close to the predicted value of -12.1 {\mu}V/K.Comment: 16 pages, 7 figures, 2 table
Strategies used as spectroscopy of financial markets reveal new stylized facts
We propose a new set of stylized facts quantifying the structure of financial
markets. The key idea is to study the combined structure of both investment
strategies and prices in order to open a qualitatively new level of
understanding of financial and economic markets. We study the detailed order
flow on the Shenzhen Stock Exchange of China for the whole year of 2003. This
enormous dataset allows us to compare (i) a closed national market (A-shares)
with an international market (B-shares), (ii) individuals and institutions and
(iii) real investors to random strategies with respect to timing that share
otherwise all other characteristics. We find that more trading results in
smaller net return due to trading frictions. We unveiled quantitative power
laws with non-trivial exponents, that quantify the deterioration of performance
with frequency and with holding period of the strategies used by investors.
Random strategies are found to perform much better than real ones, both for
winners and losers. Surprising large arbitrage opportunities exist, especially
when using zero-intelligence strategies. This is a diagnostic of possible
inefficiencies of these financial markets.Comment: 13 pages including 5 figures and 1 tabl
Probing d-wave pairing correlations in the pseudogap regime of the cuprate superconductors via low-energy states near impurities
The issue of probing the pseudogap regime of the cuprate superconductors,
specifically with regard to the existence and nature of superconducting pairing
correlations of d-wave symmetry, is explored theoretically. It is shown that if
the d-wave correlations believed to describe the superconducting state persist
into the pseudogap regime, but with pair-potential phase-fluctuations that
destroy their long-range nature, then the low-energy quasiparticle states
observed near extended impurities in the truly superconducting state should
also persist as resonances in the pseudogap regime. The scattering of
quasiparticles by these phase-fluctuations broadens what was (in the
superconducting state) a sharp peak in the single-particle spectral function at
low energy, as we demonstrate within the context of a simple model. This peak
and its broadening is, in principle, accessible via scanning tunneling
spectroscopy near extended impurities in the pseudogap regime. If so, such
experiments would provide a probe of the extent to which d-wave superconducting
correlations persist upon entering the pseudogap regime, thus providing a
stringent diagnostic of the phase-fluctuation scenario.Comment: 8 pages, 2 figure
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