X-ray and multi-epoch optical/UV investigations of BAL to non-BAL quasar transformations

We report on an X-ray and optical/UV study of eight Broad Absorption Line (BAL) to non-BAL transforming quasars at $z\,\approx\,$1.7-2.2 over 0.29-4.95 rest-frame years with at least three spectroscopic epochs for each quasar from the SDSS, BOSS, $Gemini$, and ARC 3.5-m telescopes. New $Chandra$ observations obtained for these objects show their values of $\alpha_{\rm ox}$ and $\Delta{\alpha}_{\rm ox}$, as well as their spectral energy distributions, are consistent with those of non-BAL quasars. Moreover, our targets have X-ray spectral shapes that are, on average, consistent with weakened absorption with an effective power-law photon index of $\Gamma_{\rm eff}\,=\,1.69^{+0.25}_{-0.25}$. The newer $Gemini$ and ARC 3.5-m spectra reveal that the BAL troughs have remained absent since the BOSS observations where the BAL disappearance was discovered. The X-ray and optical/UV results in tandem are consistent with at least the X-ray absorbing material moving out of the line-of-sight, leaving an X-ray unabsorbed non-BAL quasar. The UV absorber might have become more highly ionized (in a shielding-gas scenario) or also moved out of the line-of-sight (in a wind-clumping scenario).Comment: 14 pages, 5 figures, Accepted for publication in MNRA

Case report: First report on human infection by tick-borne Babesia bigemina in the Amazon region of Ecuador.

Babesiosis is a protozoan disease acquired by the bite of different species of ticks. More than 100 Babesia spp. infect wild and domestic animals worldwide, but only a few have been documented to infect humans. Generally, babesiosis is asymptomatic in immunocompetent persons; however, in immunocompromised can be life-threatening. A 13-year-old boy from the Amazon region presented with a 3-month evolution of fever, chills, general malaise, and arthralgia accompanied by anemia and jaundice. In the last 4 years was diagnosed with chronic kidney failure. By nested-PCR using 18S RNA ribosomal gene as target and DNA sequencing, the phylogenetic analysis showed Babesia bigemina as the causative agent in the blood. Treatment with oral quinine plus clindamycin for six continuous weeks was effective with no relapse occurring during 12 months of follow-up. This is the second human case in Ecuador but the first caused by the zoonotic B. bigemina which confirms the existence of active transmission that should alert public health decision-making authorities on the emergence of this zoonosis and the need for research to determine strategies to reduce tick exposure

The Koskobilo (Olazti, Navarre, Northern Iberian Peninsula) paleontological collection: New insights for the Middle and Late Pleistocene in Western Pyrenees

The destroyed site(s) of Koskobilo (Olazti, Navarre, Northern Iberian Peninsula) have yielded unique archaeo-paleontological evidence in the Western Pyrenees region. The quarry uncovered a karstic site with faunal remains in 1940, and fossils were recovered both in situ and from the quarry dump. Ten years later, while the quarry was still working, a new visit to the dump yielded a large lithic assemblage and additional fossil remains with a different taphonomic pattern, which has been interpreted as the remains coming from a different site or zone within the same karst system. Here we re-study the paleontological evidence and provide new dating on a speleothem covering a Stephanorhinus hemitoechus tooth, which has yielded a minimum date of c. 220 ka for part of the assemblage. In total, the fossil assemblage comprises 38 mammal and six avian taxa and three fish remains. The faunal evidence indicates that in 1940 a mix of taxa from both the Middle and Upper Pleistocene were recovered, and it is difficult to assign most of them to a concrete period. However, based on biochronological criteria some of the identified taxa (e.g., Ursus thibetanus, Ursus cf. deningeri, Cuon cf. priscus, Macaca sylvanus, cf. Megaceroides) could be roughly contemporaneous with the dated rhino tooth, which would provide a new window to the Middle Pleistocene of the region, with deposits from MIS 7d and/or older. Despite the difficulties in studying this collection, recovered without stratigraphic context and in a salvage operation, Koskobilo has yielded an important paleontological assemblage which helps to understand the paleoecology of the Middle Pleistocene human occupations in the Western Pyrenees

Red Dots: A temperate 1.5 Earth-mass planet candidate in a compact multi-terrestrial planet system around GJ 1061

Abstract Small low-mass stars are favourable targets for the detection of rocky habitable planets. In particular, planetary systems in the solar neighbourhood are interesting and suitable for precise characterisation. The Red Dots campaigns seek to discover rocky planets orbiting nearby low-mass stars. The 2018 campaign targeted GJ 1061, which is the 20th nearest star to the Sun. For three consecutive months we obtained nightly, high-precision radial velocity measurements with the HARPS spectrograph. We analysed these data together with archival HARPS data. We report the detection of three planet candidates with periods of 3.204 ± 0.001, 6.689 ± 0.005 and 13.03 ± 0.03 days, which are close to 1:2:4 period commensurability. After several considerations related to the properties of the noise and sampling, we conclude that a 4th signal is most likely explained by stellar rotation, although it may be due to a planet. The proposed three-planet system (and the potential four-planet solution) is long-term dynamically stable. Planet-planet gravitational interactions are below our current detection threshold. The minimum masses of the three planets range from 1.4±0.2 to 1.8±0.3 M⊕. Planet d, with msin i = 1.64 ± 0.24M⊕, receives a similar amount of energy as Earth receives from the Sun. Consequently it lies within the liquid-water habitable zone of the star and has a similar equilibrium temperature to Earth. GJ 1061 has very similar properties to Proxima Centauri but activity indices point to lower levels of stellar activity

Coordinated X-ray and UV absorption within the accretion disk wind of the active galactic nucleus PG 1126-041

Accretion disk winds launched close to supermassive black holes (SMBHs) are a viable mechanism to provide feedback between the SMBH and the host galaxy. We aim to characterize the X-ray properties of the inner accretion disk wind of the nearby active galactic nucleus (AGN) PG 1126-041, and to study its connection with the ultraviolet (UV)-absorbing wind. We perform spectroscopic analysis of eight XMM-Newton observations of PG 1126-041 taken between 2004 and 2015, using both phenomenological models and the most advanced accretion disk wind models available. For half of the dataset, we can compare the X-ray analysis results with the results of quasi-simultaneous, high-resolution spectroscopic UV observations taken with the Cosmic Origins Spectrograph (COS) on board the Hubble Space Telescope. The X-ray spectra of PG 1126-041 are complex and absorbed by ionized material which is highly variable on multiple time scales, sometimes as short as 11 days. Accretion disk wind models can account for most of the X-ray spectral complexity of PG 1126-041, with the addition of massive clumps, represented by a partially covering absorber. Variations in column density ($N_H \sim 5-20 \times 10^{22}$ cm$^{-2}$) of the partially covering absorber drive the observed X-ray spectral variability of PG 1126-041. The absorption from the X-ray partially covering gas and from the blueshifted C IV troughs appear to vary in a coordinated way. The line of sight toward PG 1126-041 offers a privileged view through a highly dynamic nuclear wind originating on inner accretion disk scales, making the source a very promising candidate for future detailed studies of the physics of accretion disk winds around SMBHs.Comment: 24 pages, 13 figures, accepted for publication in Astronomy & Astrophysic

Cfr(B), cfr(C), and a New cfr-Like Gene, cfr(E), in Clostridium difficile Strains Recovered across Latin America

Indexación: Scopus.Cfr is a radical S-adenosyl-L-methionine (SAM) enzyme that confers cross-resistance to antibiotics targeting the 23S rRNA through hypermethylation of nucleotide A2503. Three cfr-like genes implicated in antibiotic resistance have been described, two of which, cfr(B) and cfr(C), have been sporadically detected in Clostridium difficile. However, the methylase activity of Cfr(C) has not been confirmed. We found cfr(B), cfr(C), and a cfr-like gene that shows only 51 to 58% protein sequence identity to Cfr and Cfr-like enzymes in clinical C. difficile isolates recovered across nearly a decade in Mexico, Honduras, Costa Rica, and Chile. This new resistance gene was termed cfr(E). In agreement with the anticipated function of the cfrlike genes detected, all isolates exhibited high MIC values for several ribosome-targeting antibiotics. In addition, in vitro assays confirmed that Cfr(C) and Cfr(E) methylate Escherichia coli and, to a lesser extent, C. difficile 23S rRNA fragments at the expected positions. The analyzed isolates do not have mutations in 23S rRNA genes or genes encoding the ribosomal proteins L3 and L4 and lack poxtA, optrA, and pleuromutilin resistance genes. Moreover, these cfr-like genes were found in Tn6218-like transposons or integrative and conjugative elements (ICE) that could facilitate their transfer. These results indicate selection of potentially mobile cfr-like genes in C. difficile from Latin America and provide the first assessment of the methylation activity of Cfr(C) and Cfr(E), which belong to a cluster of Cfr-like proteins that does not include the functionally characterized enzymes Cfr, Cfr(B), and Cfr(D).https://journals.asm.org/doi/10.1128/AAC.01074-1

Sex and gender differences in acute stroke care: metrics, access to treatment and outcome. A territorial analysis of the Stroke Code System of Catalonia

Introduction: Previous studies have reported differences in the management and outcome of women stroke patients in comparison with men. We aim to analyze sex and gender differences in the medical assistance, access to treatment and outcome of acute stroke patients in Catalonia. Patients and methods: Data were obtained from a prospective population-based registry of stroke code activations in Catalonia (CICAT) from January/2016 to December/2019. The registry includes demographic data, stroke severity, stroke subtype, reperfusion therapy, and time workflow. Centralized clinical outcome at 90 days was assessed in patients receiving reperfusion therapy. Results: A total of 23,371 stroke code activations were registered (54% men, 46% women). No differences in prehospital time metrics were observed. Women more frequently had a final diagnosis of stroke mimic, were older and had a previous worse functional situation. Among ischemic stroke patients, women had higher stroke severity and more frequently presented proximal large vessel occlusion. Women received more frequently reperfusion therapy (48.2% vs 43.1%, p < 0.001). Women tended to present a worse outcome at 90 days, especially for the group receiving only IVT (good outcome 56.7% vs 63.8%; p < 0.001), but not for the group of patients treated with IVT + MT or MT alone, although sex was not independently associated with clinical outcome in logistic regression analysis (OR 1.07; 95% CI, 0.94–1.23; p = 0.27) nor in the analysis after matching using the propensity score (OR 1.09; 95% CI, 0.97–1.22). Discussion and conclusion: We found some differences by sex in that acute stroke was more frequent in older women and the stroke severity was higher. We found no differences in medical assistance times, access to reperfusion treatment and early complications. Worse clinical outcome at 90 days in women was conditioned by stroke severity and older age, but not by sex itself

Selection of the solvent and extraction conditions for maximum recovery of antioxidant phenolic compounds from coffee silverskin

The extraction of antioxidant phenolic compounds from coffee silverskin (CS) was studied. Firstly, the effect of different solvents (methanol, ethanol, acetone, and distilled water) on the production of antioxidant extracts was evaluated. All the extracts showed antioxidant activity (FRAP and DPPH assays), but those obtained with methanol and ethanol had significantly higher (p < 0.05) DPPH inhibition than the remaining ones. Due to the lower toxicity, ethanol was selected as extraction solvent, and further experiments were performed in order to define the solvent concentration, solvent/solid ratio, and time to maximize the extraction results. The best condition to produce an extract with high content of phenolic compounds (13 mg gallic acid equivalents/g CS) and antioxidant activity [DPPH = 18.24 μmol Trolox equivalents/g CS and FRAP = 0.83 mmol Fe(II)/g CS] was achieved when using 60 % ethanol in a ratio of 35 ml/g CS, during 30 min at 60–65 °C.This work was supported by the Portuguese Foundation for Science and Technology (FCT). The authors gratefully acknowledge Teresa Conde, student of Biological Engineering, for the help and interest in this work