87 research outputs found
PĂ©ter MihĂĄly, A leplezĆ nyelv. ĂlcĂĄzĂĄs Ă©s ĂĄmĂtĂĄs a nyelv hasznĂĄlatĂĄban. Tinta KönyvkiadĂł, Budapest, 2012. 168 lap
102
Szemle
VĂ©key
Debreczeni gr.
25 egyezés
Bél-féle Magyar
grammatika...
13 egyezés
Verseghy:
Magyar gr.
11 egyezés
Imperative
parancs mĂłd
ParantsolĂł MĂłd
ParantsolĂł mĂłd
ParancsolĂł mĂłd
Imperfect
aligmĂșlt
aligmĂșlt
FĂ©lbemĂșlt
FĂ©lmĂșltt/alligmĂșltt
Impersonal Verb
személytelen ige
â
Személytelen
SzemĂ©lyetlen Ăge
Indicative
jelentĆ mĂłd
JelentĆ mĂłd
JelentĆ mĂłd
JelentĆ mĂłd
Infinitive
hatĂĄrozatlan
mĂłd
hatĂĄrozatlan
mĂłd
HatĂĄrozatlan
mĂłd
HatĂĄrozatlan mĂłd
Irregular Verb
rendetlen ige
Rendetlen v.
RegulĂĄlatlan
Igék
Rendetlen
igék
rendhagyĂł ĂgĂ©k
Neuter Verb
KözĂ©p Ăge
Közép Ige
Közép igék
KözéprendƱ ige
Nominative
elsĆ ejtĂ©s
elsĆ ejtĂ©s
NevezĆ eset
NevezĆ eset
Object
tĂĄrgy
â
â
â
Participle
rĂ©szesƱlĆ
rĂ©szesĂŒlĆ
RĂ©szeltetĆ szĂł
RĂ©szesƱlĆ eset
Passive Verb
szenvedĆ Ăge
szenvedĆ ige
SzenvedĆ ige
szenvedĆ ige
Plural
többes szåm
Többes
Többes szåm
Többes szåm
Pluperfect
rĂ©gen mĂșlt
RĂ©gennmĂșlt
RĂ©gen mĂșlt
RĂ©genmĂșltt
Preposition
elĆlutĂłljĂĄrĂł
ElĆlutĂłljĂĄrĂł
SzĂłtfejezĆ
NĂ©vhatĂĄrozĂł
Present
jelen idĆ
JelenvalĂł idĆ
Mostani
JelenvalĂł ĂŒdĆ
Pronoun
névmås
NĂ©vmĂĄss
névmås
NĂ©vpĂłtolĂł
Person
személy
személy
személy
személy
Root (radix)
törzs, gyök
gyökér
Törsök Szó
Gyökér (Etymon)
Singular
egyes szĂĄm
Egygyes
egyes szĂĄm
Eggyes szĂĄm
Subject
alapszĂł, alany
NevezĆdött
â
â
s
Z
ili
K
atalin
S
Z
EMLE
PĂ©ter
m
ihĂĄly, A leplezĆ nyelv.
ĂĄ
lcĂĄzĂĄs Ă©s ĂĄmĂtĂĄs a nyelv
hasznĂĄlatĂĄban
Tinta Könyvkiadó, Budapest, 2012. 168 lap
âMundus vult decipi, ergo decipiaturâ (âA vilĂĄg azt akarja, hogy becsapjĂĄk, tehĂĄt csap
-
juk beâ) â tartja egy rĂ©gi latin mondĂĄs; a nyelvrĆl Wittgenstein is hasonlĂłan fogalmazott:
âA nyelv ĂĄlruhĂĄba öltözteti a gondolatot.â
P
Ă©ter
M
i
H
ĂĄly
Ășj mƱvĂ©ben, a Tinta KönyvkiadĂł
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nĂĄl a közelmĂșltban megjelent A leplezĆ nyelv â ĂlcĂĄzĂĄs Ă©s ĂĄmĂtĂĄs a nyelv hasznĂĄlatĂĄban
cĂmƱ könyvben a nyelvi leplezĂ©s (ĂĄlcĂĄzĂĄs Ă©s ĂĄmĂtĂĄs) gyakori Ă©s fontosabb eszközeit veszi
szåmba a magyar és néhåny mås nyelv anyaga alapjån
4-Sulfonatocalixarene-induced nanoparticle formation of methylimidazolium-conjugated dextrans: Utilization for drug encapsulation
Methylimidazolium side groups were grafted via ether linkage to dextran and the self-assembly of these polymers with 4-sulfonato-calix[n]arenes (SCXn) was studied in aqueous solutions. Dynamic light scattering and zeta potential measurements revealed the mixing ratio ranges of the constituents where stable nanoparticles could be created. The macrocycle size of SCXn and the molecular mass of the polymer barely affected the nanoparticle diameter, but the lowering of the imidazolium degree of substitution substantially diminished the stability of the associates. The pH change from neutral to acidic also unfavourably influenced the self-organization owing mainly to the decrease of the SCXn charge. Cryogenic transmission electron microscopy images proved the spherical morphology of the nanoproducts in which the stoichiometry of the constituents was always close to the one corresponding to charge compensation. The flexible and positively charged dextran-chains are compacted by the polyanionic SCXn. Coralyne, a pharmacologically important alkaloid was efficiently embedded by self-assembly in the produced nanoparticles reaching 99% association efficiency. © 2019 Elsevier Lt
Comparison of the direct effects of human adipose- and bone-marrow-derived stem cells on postischemic cardiomyoblasts in an in vitro simulated ischemia-reperfusion model.
Regenerative therapies hold a promising and exciting future for the cure of yet untreatable diseases, and mesenchymal stem cells are in the forefront of this approach. However, the relative efficacy and the mechanism of action of different types of mesenchymal stem cells are still incompletely understood. We aimed to evaluate the effects of human adipose- (hASC) and bone-marrow-derived stem cells (hBMSCs) and adipose-derived stem cell conditioned media (ACM) on the viability of cardiomyoblasts in an in vitro ischemia-reperfusion (I-R) model. Flow cytometric viability analysis revealed that both cell treatments led to similarly increased percentages of living cells, while treatment with ACM did not (I-R model: 12.13 +/- 0.75%; hASC: 24.66 +/- 2.49%; hBMSC: 25.41 +/- 1.99%; ACM: 13.94 +/- 1.44%). Metabolic activity measurement (I-R model: 0.065 +/- 0.033; hASC: 0.652 +/- 0.089; hBMSC: 0.607 +/- 0.059; ACM: 0.225 +/- 0.013; arbitrary units) and lactate dehydrogenase assay (I-R model: 0.225 +/- 0.006; hASC: 0.148 +/- 0.005; hBMSC: 0.146 +/- 0.004; ACM: 0.208 +/- 0.009; arbitrary units) confirmed the flow cytometric results while also indicated a slight beneficial effect of ACM. Our results highlight that mesenchymal stem cells have the same efficacy when used directly on postischemic cells, and differences found between them in preclinical and clinical investigations are rather related to other possible causes such as their immunomodulatory or angiogenic properties
TDP-43 Proteinopathy in Aging: Associations with Risk-Associated Gene Variants and with Brain Parenchymal Thyroid Hormone Levels
TDP-43 proteinopathy is very prevalent among the elderly (affecting at least 25% of individuals over 85âŻyears of age) and is associated with substantial cognitive impairment. Risk factors implicated in age-related TDP-43 proteinopathy include commonly inherited gene variants, comorbid Alzheimer\u27s disease pathology, and thyroid hormone dysfunction. To test parameters that are associated with aging-related TDP-43 pathology, we performed exploratory analyses of pathologic, genetic, and biochemical data derived from research volunteers in the University of Kentucky Alzheimer\u27s Disease Center autopsy cohort (nâŻ=âŻ136 subjects). Digital pathologic methods were used to discriminate and quantify both neuritic and intracytoplasmic TDP-43 pathology in the hippocampal formation. Overall, 46.4% of the cases were positive for TDP-43 intracellular inclusions, which is consistent with results in other prior community-based cohorts. The pathologies were correlated with hippocampal sclerosis of aging (HS-Aging) linked genotypes. We also assayed brain parenchymal thyroid hormone (triiodothyronine [T3] and thyroxine [T4]) levels. In cases with SLCO1A2/IAPP or ABCC9 risk associated genotypes, the T3/T4 ratio tended to be reduced (pâŻ=âŻ.051 using 2-tailed statistical test), and in cases with low T3/T4 ratios (bottom quintile), there was a higher likelihood of HS-Aging pathology (pâŻ=âŻ.025 using 2-tailed statistical test). This is intriguing because the SLCO1A2/IAPP and ABCC9 risk associated genotypes have been associated with altered expression of the astrocytic thyroid hormone receptor (protein product of the nearby gene SLCO1C1). These data indicate that dysregulation of thyroid hormone signaling may play a role in age-related TDP-43 proteinopathy
Development of Population Tariffs for the CarerQol Instrument for Hungary, Poland and Slovenia
__Background:__ The CarerQol instrument can be used in economic evaluations to measure the care-related quality of life of informal caregivers. Tariff sets are available for Australia, Germany, Sweden, the Netherlands, the UK, and the USA.
__Objective:__ Our objective was to develop tariff sets for the CarerQol instrument for Hungary, Poland and Slovenia and to compare these with the existing value sets.
__Methods:__ Discrete-choice experiments were carried out in Hungary, Poland and Slovenia. Data were collected through an online survey between November 2018 and January 2019, using representative samples of 1000 respondents per country. Tariffs were calculated from coefficient estimates from panel mixed multinomial logit models with random parameters.
__Results:__ All seven CarerQol domains contributed significantly to the utility associated with different caregiving situations. Attributes valued highest were âphysical health
PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma
Filamin A organizes Îłâaminobutyric acid type B receptors at the plasma membrane
The γ-aminobutyric acid type B (GABA(B)) receptor is a prototypical family C G protein-coupled receptor (GPCR) that plays a key role in the regulation of synaptic transmission. Although growing evidence suggests that GPCR signaling in neurons might be highly organized in time and space, limited information is available about the mechanisms controlling the nanoscale organization of GABA(B) receptors and other GPCRs on the neuronal plasma membrane. Using a combination of biochemical assays in vitro, single-particle tracking, and super-resolution microscopy, we provide evidence that the spatial organization and diffusion of GABA(B) receptors on the plasma membrane are governed by dynamic interactions with filamin A, which tethers the receptors to sub-cortical actin filaments. We further show that GABA(B) receptors are located together with filamin A in small nanodomains in hippocampal neurons. These interactions are mediated by the first intracellular loop of the GABA(B1) subunit and modulate the kinetics of Gα(i) protein activation in response to GABA stimulation
Understanding and Exploitation of Neighboring Heteroatom Effect for the Mild N-arylation of Heterocycles with Diaryliodonium Salts under Aqueous Conditions: A Theoretical and Experimental Mechanistic Study.
The mechanism of
arylation of N-heterocycles with unsymmetric diaryliodonium
salts is elucidated. The fast and efficient N-arylation reaction is
interpreted in terms of the bifunctionality of the substrate: The
consecutive actions of properly oriented Lewis base and BrĂžnsted
acid centers in sufficient proximity result in the fast and efficient
N-arylation. The mechanistic picture points to a promising synthetic
strategy where suitably positioned nucleophilic and acidic centers
enable functionalization, and it is tested experimentally
Understanding and Exploitation of Neighboring Heteroatom Effect for the Mild NArylation of Heterocycles with Diaryliodonium Salts under Aqueous Conditions: A Theoretical and Experimental Mechanistic Study
The Effects of Hyperacute Serum on the Elements of the Human Subchondral Bone Marrow Niche
Mesenchymal stem cells (MSCs) are widely used in laboratory experiments as well as in human cell therapy. Their culture requires animal sera like fetal calf serum (FCS) as essential supplementation; however, animal sera pose a risk for clinical applications. Human blood derivatives, for example, platelet-rich plasma (PRP) releasates, are potential replacements of FCS; however, it is unclear which serum variant has the best effect on the given cell or tissue type. Additionally, blood derivatives are commonly used in musculoskeletal diseases like osteoarthritis (OA) or osteonecrosis as "proliferative agents" for the topical MSC pool. Hyperacute serum (HAS), a new serum derivative, has been designed to approximate the natural coagulation cascade with a single-step, additive-free preparation method. We investigated the effects of HAS on monolayer MSC cultures and in their natural niche, in 3D subchondral bone and marrow explants. Viability measurements, RT-qPCR evaluation for gene expression and flow cytometry for cell surface marker analysis were performed to compare the effects of FCS-, PRP-, or HAS-supplemented culture media. Monolayer MSCs showed significantly higher metabolic activity following 5 days' incubation in HAS, and osteoblast-specific mRNA expression was markedly increased, while cells also retained their MSC-specific cell surface markers. A similar effect was observed on bone and marrow explants, which was further confirmed with confocal microscopy analysis. Moreover, markedly higher bone marrow preservation was observed with histology in case of HAS supplementation compared to FCS. These findings indicate possible application of HAS in regenerative solutions of skeletal diseases like OA or osteonecrosis
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