VELO Module Production - Back End Bonding

This note describes in detail the procedures used in the bonding of the ASICs (Beetle 1.5 chips) to the hybrid for the LHCb VELO detector modules

VELO Module Production - Front End Bonding

This note describes in detail the procedures used in the bonding of the ASICs (Beetle 1.5 chips) down to the Pitch Adaptors for the LHCb VELO detector modules

VELO Module Production - Sensor End Bonding

This note describes the procedures used in the bonding of the silicon to the pitch adaptors for the LHCb VELO detector modules

Understanding Algorithm Performance on an Oversubscribed Scheduling Application

The best performing algorithms for a particular oversubscribed scheduling application, Air Force Satellite Control Network (AFSCN) scheduling, appear to have little in common. Yet, through careful experimentation and modeling of performance in real problem instances, we can relate characteristics of the best algorithms to characteristics of the application. In particular, we find that plateaus dominate the search spaces (thus favoring algorithms that make larger changes to solutions) and that some randomization in exploration is critical to good performance (due to the lack of gradient information on the plateaus). Based on our explanations of algorithm performance, we develop a new algorithm that combines characteristics of the best performers; the new algorithms performance is better than the previous best. We show how hypothesis driven experimentation and search modeling can both explain algorithm performance and motivate the design of a new algorithm

VELO Module Production - Clean Room Layout, Procedures and Monitoring

This note describes in detail the procedures for access and gowning in the clean rooms

Grandmother Kinship Care Providers: Predictors of Elevated Psychological Distress

Most children in kinship care with grandmothers in the U.S. have been abandoned or maltreated. The challenges these caregivers encounter often include poverty, social isolation, and diminished health. These factors may hinder the grandmother’s ability to provide a supportive family environment. The purpose of the present study was to determine levels of psychological distress in African American caregiving grandmothers and identify predictors of increased distress in African American custodial grandmothers. We hypothesized that diminished grandmother health, family resources and support, as well as increased child behavior problems, will predict psychological distress

Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions.

Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers. This remodeling is crucial for an adequate blood supply to the fetus with a failure to remodel implicated in the etiology of the hypertensive disorder preeclampsia. The mechanism by which trophoblasts induce this key process is unknown. This study gives the first insights into the potential mechanisms involved. Methods and Results— Spiral arteries were dissected from nonplacental bed biopsies obtained at Caesarean section, and a novel model was used to mimic in vivo events. Arteries were cultured with trophoblasts in the lumen, and apoptotic changes in the endothelial layer were detected after 20 hours, leading to loss of endothelium by 96 hours. In vitro, coculture experiments showed that trophoblasts stimulated apoptosis of primary decidual endothelial cells and an endothelial cell line. This was blocked by caspase inhibition and NOK2, a FasL blocking antibody. NOK2 also abrogated trophoblast-induced endothelial apoptosis in the vessel model. Conclusions— Extravillous trophoblast induction of endothelial apoptosis is a possible mechanism by which the endothelium is removed, and vascular remodeling may occur in uterine spiral arteries. Fas/FasL interactions have an important role in trophoblast-induced endothelial apoptosis