Hyperons and massive neutron stars: vector repulsion and SU(3) symmetry

With the discovery of massive neutron stars such as PSR J1614-2230, the question has arisen whether exotic matter such as hyperons can exist in the neutron star core. We examine the conditions under which hyperons can exist in massive neutron stars. We consistently investigate the vector meson-hyperon coupling, going from SU(6) quark model to a broader SU(3) symmetry. We propose that the maximum neutron star mass decreases linearly with the strangeness content f_s of the neutron star core as M_max(f_s) = M_max(0) - 0.6 M_solar (f_s/0.1), which seems to be independent of the underlying nuclear equation of state and the vector baryon-meson coupling scheme. Thus, pulsar mass measurements can be used to constrain the hyperon fraction in neutron stars.Comment: 13 pages, 10 figure

Formation of 117In−H^{117}In-H pairs after annealing of GaN implanted with 117Cd(117In)^{117}Cd(^{117}In)

We report on the annealing behaviour of GaN grown on sapphire after implantation of 117Cd(117In). Isochronic annealing has been performed in order to remove the implantation induced lattice damage in evacuated quartz ampoules with additional Al. The extent of the lattice damage is investigated with perturbed gg-angular correlation spectroscopy (PAC). The implantation damage is annealed at temperatures above 1073 K to a large extent. 82(5) % of the probes are found on the Ga-site characterized by a quadrupole coupling constant of 20.9(1) MHz. After H loading, an additional interaction appears which is attributed to 117Cd(117In)-H pairs

Hyperons in neutron-star cores and two-solar-mass pulsar

Recent measurement of mass of PSR J1614-2230 rules out most of existing models of equation of state (EOS) of dense matter with high-density softening due to hyperonization or a phase transition to quark matter or a boson condensate. We look for a solution of an apparent contradiction between the consequences stemming from up-to-date hypernuclear data, indicating appearance of hyperons at 3 nuclear densities and existence of a two-solar-mass neutron star. We consider a non-linear relativistic mean field (RMF) model involving baryon octet coupled to meson fields. An effective lagrangian includes quartic terms in the meson fields. The values of the parameters of the model are obtained by fitting semi-empirical parameters of nuclear matter at the saturation point, as well as potential wells for hyperons in nuclear matter and the strength of the Lambda-Lambda attraction in double-Lambda hypernuclei. We propose a non-linear RMF model which is consistent with up-to-date semiempirical nuclear and hypernuclear data and allows for neutron stars with hyperon cores and M larger than 2 solar masses. The model involves hidden-strangenes scalar and vector mesons, coupled to hyperons only, and quartic terms involving vector meson fields. Our EOS involving hyperons is stiffer than the corresponding nucleonic EOS (with hyperons artificially suppressed) above five nuclear densities. Required stiffening is generated by the quartic terms involving hidden-strangeness vector meson.Comment: 7 pages, 5 figures. Main results of this paper were already presented at the MODE-SNR-PWN Workshop in Bordeaux, France, November 15-17, 2010, and in a poster at the CompStar 2011 Workshop in Catania, Italy, May 9-12, 2011. The paper is being submitted to Astronomy & Astrophysic

Enhanced human papillomavirus type 8 oncogene expression levels are crucial for skin tumorigenesis in transgenic mice

AbstractHuman papillomavirus 8 (HPV8) is involved in skin cancer development in epidermodysplasia verruciformis patients. Transgenic mice expressing HPV8 early genes (HPV8-CER) developed papillomas, dysplasias and squamous cell carcinomas. UVA/B-irradiation and mechanical wounding of HPV8-CER mouse skin led to prompt papilloma induction in about 3weeks. The aim of this study was to analyze the kinetics and level of transgene expression in response to skin irritations. Transgene expression was already enhanced 1 to 2days after UVA/B-irradiation or tape-stripping and maintained during papilloma development. The enhanced transgene expression could be assigned to UVB and not to UVA. Papilloma development was thus always paralleled by an increased transgene expression irrespective of the type of skin irritation. A knock-down of E6 mRNA by tattooing HPV8-E6-specific siRNA led to a delay and a lower incidence of papilloma development. This indicates that the early increase of viral oncogene expression is crucial for induction of papillomatosis

Cortical networks are disturbed in people with cirrhosis even in the absence of neuropsychometric impairment

OBJECTIVE: Hepatic encephalopathy is a common complication of cirrhosis; it is characterised by neuropsychometric/neurophysiological abnormalities. Its pathophysiology is complex but glial neuronal communication is likely to be disrupted and to impact on oscillatory networks and cortical connectivity. The aim of this study was to use multichannel electroencephalography (EEG) to investigate functional connectivity, as a surrogate for cortical networks, in patients with cirrhosis. METHODS: Resting EEGs were recorded in 98 healthy controls and in 264 patients with cirrhosis characterised psychometrically using the Psychometric Hepatic Encephalopathy Score (PHES). Functional connectivity was calculated using the phase-lag index with stratification into standard EEG frequency bands. The findings were validated in a further cohort of 39 healthy controls and 106 patients with cirrhosis. RESULTS: Widespread disruption in functional connectivity was observed in the patients compared with the controls; connectivity was increased in the theta (4-8 Hz) band and decreased in the delta (1-3.5 Hz), alpha (8.5-13 Hz) and beta (13.5-26.5 Hz) bands. Changes were apparent even in patients who were psychometrically unimpaired compared with healthy controls viz mean ± SEM theta 0.107 ± 0.001 vs. 0.103 ± 0.002 (p < 0.05) and alpha 0.139 ± 0.003 vs. 0.154 ± 0.003 (p < 0.01); more pronounced changes were observed with increasing neuropsychometric impairment. The findings were replicated in the second cohort. CONCLUSIONS: Cortical networks are disturbed in patients with cirrhosis even in the absence of psychometric impairment. SIGNIFICANCE: These findings will facilitate further exploration of the pathophysiology of this condition and provide a robust means for assessing treatment effects in research settings

Finiteness and children with specific language impairment: an exploratory study

Children with specific language impairment (SLI) are well known for their difficulties in mastering the inflectional paradigms; in the case of learning German they also have problems with the appropriate verb position, in particular with the verb in second position. This paper explores the possibilities of applying a broader concept of finiteness to data from children with SLI in order to put their deficits, or rather their skills, into a wider perspective. The concept, as developed by Klein (1998, 2000), suggests that finiteness is tied to the assertion that a certain state of affairs is valid with regard to some topic time; that is, finiteness relates the propositional content to the topic component. Its realization involves the interaction of various grammatical devices and, possibly, lexical means like temporal adverbs. Furthermore, in the acquisition of finiteness it has been found that scope particles play a major role in both first- and second-language learning. The purpose of this paper is to analyze to what extent three German-learning children with SLI have mastered these grammatical and lexical means and to pinpoint the phase in the development of finiteness they have reached. The data to be examined are mostly narrative and taken from conversations and experiments. It will be shown that each child chooses a different developmental path to come to grips with the interaction of these devices

Core-collapse supernova explosions triggered by a quark-hadron phase transition during the early post-bounce phase

We explore explosions of massive stars, which are triggered via the quark-hadron phase transition during the early post bounce phase of core-collapse supernovae. We construct a quark equation of state, based on the bag model for strange quark matter. The transition between the hadronic and the quark phases is constructed applying Gibbs conditions. The resulting quark-hadron hybrid equations of state are used in core-collapse supernova simulations, based on general relativistic radiation hydrodynamics and three flavor Boltzmann neutrino transport in spherical symmetry. The formation of a mixed phase reduces the adiabatic index, which induces the gravitational collapse of the central protoneutron star. The collapse halts in the pure quark phase, where the adiabatic index increases. A strong accretion shock forms, which propagates towards the protoneutron star surface. Due to the density decrease of several orders of magnitude, the accretion shock turns into a dynamic shock with matter outflow. This moment defines the onset of the explosion in supernova models that allow for a quark-hadron phase transition, where otherwise no explosions could be obtained. The shock propagation across the neutrinospheres releases a burst of neutrinos. This serves as a strong observable identification for the structural reconfiguration of the stellar core. The ejected matter expands on a short timescale and remains neutron-rich. These conditions might be suitable for the production of heavy elements via the r-process. The neutron-rich material is followed by proton-rich neutrino-driven ejecta in the later cooling phase of the protoneutron star where the vp-process might occur.Comment: 29 pages, 24 figures, submitted to Ap

Addressing the ‘hypoxia paradox’ in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues

Background: Since fall 2019, SARS-CoV-2 spread world-wide, causing a major pandemic with estimated ~ 220 million subjects affected as of September 2021. Severe COVID-19 is associated with multiple organ failure, particularly of lung and kidney, but also grave neuropsychiatric manifestations. Overall mortality reaches > 2%. Vaccine development has thrived in thus far unreached dimensions and will be one prerequisite to terminate the pandemic. Despite intensive research, however, few treatment options for modifying COVID-19 course/outcome have emerged since the pandemic outbreak. Additionally, the substantial threat of serious downstream sequelae, called ‘long COVID’ and ‘neuroCOVID’, becomes increasingly evident. Main body of the abstract: Among candidates that were suggested but did not yet receive appropriate funding for clinical trials is recombinant human erythropoietin. Based on accumulating experimental and clinical evidence, erythropoietin is expected to (1) improve respiration/organ function, (2) counteract overshooting inflammation, (3) act sustainably neuroprotective/neuroregenerative. Recent counterintuitive findings of decreased serum erythropoietin levels in severe COVID-19 not only support a relative deficiency of erythropoietin in this condition, which can be therapeutically addressed, but also made us coin the term ‘hypoxia paradox’. As we review here, this paradox is likely due to uncoupling of physiological hypoxia signaling circuits, mediated by detrimental gene products of SARS-CoV-2 or unfavorable host responses, including microRNAs or dysfunctional mitochondria. Substitution of erythropoietin might overcome this ‘hypoxia paradox’ caused by deranged signaling and improve survival/functional status of COVID-19 patients and their long-term outcome. As supporting hints, embedded in this review, we present 4 male patients with severe COVID-19 and unfavorable prognosis, including predicted high lethality, who all profoundly improved upon treatment which included erythropoietin analogues. Short conclusion: Substitution of EPO may—among other beneficial EPO effects in severe COVID-19—circumvent downstream consequences of the ‘hypoxia paradox’. A double-blind, placebo-controlled, randomized clinical trial for proof-of-concept is warrante

Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia

Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically – transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as ‘immunoprecipitator’ of autoantibodies against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB). We thus hypothesized that during human anesthesia, pre-existing NMDAR1-AB will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No changes in albumin, thyroglobulin or CRP were associated with reduction of serum NMDAR1-AB. Thus, upon anesthesia, BBB opening likely occurs also in humans

Task sharing in an interprofessional medication management program – a survey of general practitioners and community pharmacists

Background Pharmacist-led medication review and medication management programs (MMP) are well-known strategies to improve medication safety and effectiveness. If performed interprofessionally, outcomes might even improve. However, little is known about task sharing in interprofessional MMP, in which general practitioners (GPs) and community pharmacists (CPs) collaboratively perform medication reviews and continuously follow-up on patients with designated medical and pharmaceutical tasks, respectively. In 2016, ARMIN (Arzneimittelinitiative Sachsen-Thüringen) an interprofessional MMP was launched in two German federal states, Saxony and Thuringia. The aim of this study was to understand how GPs and CPs share tasks in MMP when reviewing the patients’ medication. Methods This was a cross-sectional postal survey among GPs and CPs who participated in the MMP. Participants were asked who completed which MMP tasks, e.g., checking drug-drug interactions, dosing, and side effects. In total, 15 MMP tasks were surveyed using a 5-point Likert scale ranging from “I complete this task alone” to “GP/CP completes this task alone”. The study was conducted between 11/2020 and 04/2021. Data was analyzed using descriptive statistics. Results In total, 114/165 (69.1%) GPs and 166/243 (68.3%) CPs returned a questionnaire. The majority of GPs and CPs reported (i) checking clinical parameters and medication overuse and underuse to be completed by GPs, (ii) checking storage conditions of drugs and initial compilation of the patient’s medication including brown bag review being mostly performed by CPs, and (iii) checking side-effects, non-adherence, and continuous updating of the medication list were carried out jointly. The responses differed most for problems with self-medication and adding and removing over-the-counter medicines from the medication list. In addition, the responses revealed that some MMP tasks were not sufficiently performed by either GPs or CPs. Conclusions Both GPs’ and CPs’ expertise are needed to perform MMP as comprehensively as possible. Future studies should explore how GPs and CPs can complement each other in MMP most efficiently