Determinant of Non-performing Financing in Indonesia Islamic Bank

In 2017, there was an increase in Non Performing Financing (NPF) in Islamic Bank until the NPF Ratio reached five point twenty seven percent. It shows that NPF Ratio in that period has exceeded the standard provision of Bank Indonesia of five percent. This phenomenon is one of things that caused by the high channeling of financing to customers without accompanied by an increase in financing quality. This study aims to examine the determinants of non performing financing period 2013-2018. This study uses secondary data from six Indonesia Islamic Bank. This study used descriptive explanatory method with data analysis technique is panel data regression. The dependent variable used in this study is the non performing financing. Furthermore, the independent variables are Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR) and Bank Indonesia Sharia Certificates (SBIS). The results showed that the CAR and FDR have a significant negative effect on NPF. While, the SBIS rate has not effect on NPF. The result of simultaneous regression show that the CAR, FDR and SBIS rate have effect on NPF. Thus it can be concluded that when CAR and FDR increases, it will decrease the NPF and when SBIS increases, it does not affect the NPF.     Keywords: Non Performing Financing (NPF), Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR), SBIS rate

Improvement in clinical markers in CF patients using a reduced glutathione regimen: An uncontrolled, observational study

AbstractCFTR mutation, which causes cystic fibrosis (CF), has also recently been identified as causing glutathione system dysfunction and systemic deficiency of reduced glutathione (GSH). Such dysfunction and deficiency regarding GSH may contribute to the pathophysiology of CF. We followed 13 patients (age range 1–27 years) with cystic fibrosis who were using a regimen of reduced glutathione (GSH), including oral glutathione and inhaled buffered glutathione in an uncontrolled, observational study. Dosage ranged from 66–148 mg/kg/day in divided doses, and the term examined was the initial 5.5 months of GSH use (45 days of incrementally adjusted dose, plus 4 months of use at full dosage). Baseline and post-measurements of FEV1 percent predicted, BMI percentile, and weight percentile were noted, in addition to bacterial status and pulmonary exacerbations. Significant improvement in the following clinical parameters was observed: average improvement in FEV1 percent predicted (N=10) was 5.8 percentage points (p<0.0001), average weight percentile (N=13) increased 8.6 points (p<0.001), BMI percentile (N=11) improved on average 1.22 points (p<0.001). All patients improved in FEV1 and BMI, if measured in their case; 12 of 13 patients improved in weight percentile. Positive sputum cultures of bacteria in 11 patients declined from 13 to 5 (p<0.03) with sputum cultures of Pseudomonas aeruginosa becoming negative in 4 of 5 patients previously culturing PA, including two of three patients chronically infected with PA as determined by antibody status. Use of a daily GSH regimen appears to be associated in CF patients with significant improvement in lung function and weight, and a significant decline in bacteria cultured in this uncontrolled study. These findings bear further clinical investigation in larger, randomized, controlled studies

Oral health conditions and cardiovascular diseases in elderly italian patient

BACKGROUND: The objective of this study was to investigate the associations between oral health status and presence of cardiovascular diseases (CVD) in elderly patients. METHODS: The study population consisted of 533 patients (308 females, 225 males) aged 65 to 98 years. The mean age of patients was 73.93 (±7.8 standard deviation (SD)). Patients were asked to visit the Geriatric Dentistry Department of “Policlinico Umberto I” of Rome for a routine check of their oral health status. All subjects gave informed, signed consent to participate in the study. A predesigned medical history questionnaire including social status, habits, medical history, general health and drug assumption were filled by each patient. Medical history, particularly focused on CV D and common atherosclerotic risk factors (arterial hypertension, diabetes, body mass index, etc.) have been recorded. Dental status was detected measuring the Decayed, Missing, and Filled Teeth (DMFT) and Community Periodontal Index (CPI) indexes. Geriatric Oral Health Assessment Index (GOHAI ) was also used to evaluate masticatory function, oral self-perception and psychosocial impact on patients. The chi-square test with a 95% confidence level was used to assess qualitative variables. Odds ratios (ORs) and stepwise logistic regression were used to calculate risk estimates; the independent variables: age, gender, DMFT, CPI index, GOHAI index score, and tooth loss were included in the statistical model. P value &lt;0.05 was considered a statistically significant cut-off. RESULT S:S: The mean of the DMFT was 13.8 (SD: 7.1). Among all patients, 8.6% (n = 46) had more than 12 decayed teeth, 43.7% (n = 233) had more than 12 missing teeth. A total of 122 patients (52.4%) had more than 18 missing teeth. No difference between females and males was seen in DMFT and CPI index. GOHAI data were worst for females and it significantly decreased with age. Vascular diseases affected 69.8% of subjects (n = 372). Patients with CVD had less education and oral care (P &lt; 0.05), higher CPI index and lower of filled teeth (P &lt; 0.05). Moreover, the number of missing teeth was higher in patients with vascular disease and patients with more than 18 missing teeth have 2.5 times greater risk of CVD. CVDs are also associated with type 2 diabetes mellitus, underweight, and obesity (P &lt; 0.05).CONCLUSIONS: From the finding of this study, it can be confirmed a significant link between CVD and oral health. A cooperation among geriatrician, cardiologist, and dentist is suitable to counteract the development of CVD and to early identify patients risk of CVD

Neutron sources based on medical Linac

The paper proposes the study of a novel photo-neutron source based on a medical high-energy electron Linac. Previous studies by the authors already demonstrated the possibility to obtain with this technique a thermal neutron flux of the order of 107 cm−2 s−1. This paper shows possible Linac’s setup and a new photo-converter design to reach a thermal neutron flux around 6 × 107 cm−2 s−1, keeping a reasonable high quality of the beam with respect to fast neutron and gamma contaminations

Draft Genome Sequence of the Carboxydotrophic Alphaproteobacterium Aminobacter carboxidus Type Strain DSM 1086

Aminobacter carboxidus is a soil Gram-negative alphaproteobacterium belonging to the physiological group of carboxydobacteria which aerobically oxidize CO to CO2. Here, we report the draft genome sequence of the A. carboxidus DSM 1086 type strain and the identification of both form I and form II CO dehydrogenase systems in this strain

Draft genome sequence and secondary metabolite biosynthetic potential of the lysobacter niastensis type strain DSM 18481

Lysobacter niastensis belongs to a group of bacterial predators that produce a number of bioactive small molecules endowed with lytic properties toward other microorganisms. Here, we report the draft genome sequence of the type strain DSM 18481 and the identification of gene clusters implicated in the biosynthesis of secondary metabolites

Ferrous Campylobacter jejuni truncated hemoglobin P displays an extremely high reactivity for cyanide - A comparative study

Campylobacter jejuni hosts two hemoglobins (Hbs). The Camplylobacter jejuni single-domain Hb (called Cgb) is homologous to the globin domain of flavohemoglobin, and it has been proposed to protect the bacterium against nitrosative stress. The second Hb is called Ctb (hereafter Cj-trHbP), belongs to truncated Hb group III, and has been hypothesized to be involved in O 2 chemistry. Here, the kinetics and thermodynamics of cyanide binding to ferric and ferrous Cj-trHbP [Cj-trHbP(III) and Cj-trHbP(II), respectively] are reported and analyzed in parallel with those of related heme proteins, with particular reference to those from Mycobacterium tuberculosis. The affinity of cyanide for Cj-trHbP(II) is higher than that reported for any known (in)vertebrate globin by more than three orders of magnitude (K = 1.2 × 10-6 m). This can be fully attributed to the highest (ever observed for a ferrous Hb) cyanide-binding association rate constant (kon = 3.3 × 103 m-1·s-1), even though the binding process displays a rate-limiting step (kmax = 9.1 s -1). Cj-trHbP(III) shows a very high affinity for cyanide (L = 5.8 × 10-9 m); however, cyanide association kinetics are independent of cyanide concentration, displaying a rate-limiting step (l max = 2.0 × 10-3 s-1). Values of the first-order rate constant for cyanide dissociation from Cj-trHbP(II)-cyanide and Cj-trHbP(III)-cyanide (koff =5.0 × 10-3 s -1 and loff ≥ 1 × 10-4 s-1, respectively) are similar to those reported for (in)vertebrate globins. The very high affinity of cyanide for Cj-trHbP(II), reminiscent of that of horseradish peroxidase(II), suggests that this globin may participate in cyanide detoxification. © 2008 The Authors

Effectiveness of a Pulmonary Rehabilitation Program on Persistent Asthma Stratified for Severity

BACKGROUND: Asthma is defined by airway inflammation associated with various respiratory symptoms, and pharmacologic treatment is based on inhaled corticosteroids and bronchodilators. Physical activity, educational training, nutritional support, and psychological counseling are considered part of non-pharmacologic treatment; however, studies so far have investigated the effect of single non-pharmacologic treatment. There are few studies that demonstrate the effect of comprehensive pulmonary rehabilitation, but no clear data are available regarding factors that can predict who could benefit the most. Our study aimed to assess the effect of a comprehensive 3-week pulmonary rehabilitation program on exercise tolerance and to identify baseline subject characteristics that may predict a better response to treatment. METHODS: This was a retrospective study. A team planned a pulmonary rehabilitation program: educational support; endurance training; and optional components, such as respiratory exercises and airway clearance techniques. The following data were collected before and after pulmonary rehabilitation: subject characteristics, smoking history, asthma severity, respiratory function and 6-min walk test (6MWT). RESULTS: We collected data on 515 subjects (202 males 39.2%), age, mean \ub1 SD 63.9 \ub1 10.4 y), with 413 (80.2%) having moderate-to-severe disease; and 455 (88.4%) with stable respiratory symptoms 455 (88.35%). At baseline, the percentage of predicted 6MWT in all subjects categorized by the Global Initiative for Asthma (GINA) steps was in the normal range, except for the subjects at step 5, for which it was significantly lower (P = .01). All subjects showed a significant improvement in exercise tolerance and oxygen saturation, together with a decrease in baseline dyspnea, muscle fatigue, and heart rate after pulmonary rehabilitation. Improvement of 6MWT was statistically significant, irrespective of the GINA categorization. The variables related to the improvement in 6MWT were age (P &lt; .001), smoking habit (P = .034), and baseline 6MWT (P &lt; .001). CONCLUSIONS: Subjects with asthma at any GINA step seemed to benefit from a pulmonary rehabilitation program; analysis of our data highlighted that pulmonary rehabilitation was more beneficial in younger subjects with a smoking history and worse baseline exercise tolerance