Comparison in Various Bioactive Compounds of Leaves and Seeds of Foeniculum Vulgare Mill.

Medicinal plants a gift of nature are being used against various infections and diseases in the subcontinent since past history. Herbs were use as food ( vegetables ) and flavors for hundred of years in many parts of world. Whereas number of herbs have also been traditionally regarded as natural remedies for common ailments of human population. Furthermore some herbal plants are considered as house of medicines and played an important role in nearly every culture on earth, including Asia, Africa, Europe and the Americas. A study was conducted to analyze the Leaves and seeds of Foeniculum vulgare for different bioactive compounds those includes saponins , total proteins, amino acids, fat and flavonoids with one and two dimensional thin layer and column chromatography followed by spectrophotometric analysis. Results indicates that leaves contained higher concentration of flavonoids and fat. Where as level of Saponins, proteins, amino acids, total minerals and other organic compounds was high in seeds. The analysis of leave and seeds of Foeniculum vulgare for these valuable organic compounds will provide important raw materials that can be used for preparation of medicines in Pharmaceuticals companies. Furthermore interest of people in plant made medicines are increasing due to their concern about the side effects of powerful synthetic drugs and high prices of these medicines. It is expected that raw material obtained from plants will not only reduce the prices of medicines in the pharmaceutical market but also provide rapid and reliable system of treatment of various infection and disease of human populatio

4-Nitro­phenyl 2-methyl­benzoate

The title compound, C14H11NO4, crystallizes with two mol­ecules in the asymmetric unit. The major conformational difference between these two mol­ecules is the dihedral angle between the aromatic rings, namely 36.99 (5) and 55.04 (5)°. The nitro groups are coplanar with the phenyl rings to which they are attached, the O—N—C—C torsion angles being −1.9 (3) and 1.0 (3)° in the two mol­ecules

Detection & Distinction of Colors using Color Sorting Robotic Arm in a Pick & Place Mechanism

Color sorting Robot is one of the useful, costless and fastest systems in Industrial applications to reduce manual working time and provides less human mistake when manual system is undertaken. The objective of this project is to design an efficient, microcontroller based system that pick up right color of objects and put it down at right place to optimize the productivity, minimizing the cost of the products and decreasing human mistakes. The controller used is a PIC Microcontroller (18F452) having high speed performance, low cost and 32 K bytes program memory. It communicates with color sensor TCS 3200 and various motor modules in real time to detect the right color object and to control the arm movement. Designed system can pick objects of 1kG weight and arm can rotate up to 3600 . Also, the use of easily available components reduces the manufacturing and maintenance costs. The design is quite flexible as the software can be changed according to specific requirements of the user. This makes the proposed system to be an economical, portable and a low maintenance solution for industrial applications

Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone

BACKGROUND: Biotransformation is an effective technique for the synthesis of libraries of bioactive compounds. Current study on microbial transformation of dihydrotestosterone (DHT) (1) was carried out to produce various functionalized metabolites. RESULTS: Microbial transformation of DHT (1) by using two fungal cultures resulted in potent butyrylcholinesterase (BChE) inhibitors. Biotransformation with Macrophomina phaseolina led to the formation of two known products, 5α-androstan-3β,17β-diol (2), and 5β-androstan-3α,17β-diol (3), while biotransformation with Gibberella fujikuroi yielded six known metabolites, 11α,17β-dihydroxyandrost-4-en-3-one (4), androst-1,4-dien-3,17-dione (5), 11α-hydroxyandrost-4-en-3,17-dione (6), 11α-hydroxyandrost-1,4-dien-3,17-dione (7), 12β-hydroxyandrost-1,4-dien-3,17-dione (8), and 16α-hydroxyandrost-1,4-dien-3,17-dione (9). Metabolites 2 and 3 were found to be inactive, while metabolite 4 only weakly inhibited the enzyme. Metabolites 5–7 were identified as significant inhibitors of BChE. Furthermore, predicted results from docking simulation studies were in complete agreement with experimental data. Theoretical results were found to be helpful in explaining the possible mode of action of these newly discovered potent BChE inhibitors. Compounds 8 and 9 were not evaluated for enzyme inhibition activity both in vitro and in silico, due to lack of sufficient quantities. CONCLUSION: Biotransformation of DHT (1) with two fungal cultures produced eight known metabolites. Metabolites 5–7 effectively inhibited the BChE activity. Cholinesterase inhibition is among the key strategies in the management of Alzheimer’s disease (AD). The experimental findings were further validated by in silico inhibition studies and possible modes of action were deduced

DIP Based Smart Door Lock System

In this era of digital development, the requirement of efficient security parameters to safeguard privacy becomes a necessity. In this paper, an effective implementation of security is used by the means of face recognition technology and the widely used One Time Password (OTP) generated with Group Special Mobile (GSM). These technologies when used together help to protect privacy. Conventionally, the modes of security to safeguard privacy are key locks and chains. But these can be sabotaged and the desired area can be open to unauthorized members. With this system, the need for keys can be completely eliminated. This paper provides a cognitive framework to serve the purpose of security with easy utility and cost effectiveness. In order to gain access to a secured area, face recognition technique is used with the help of digital image processing to recognize and allow only authorized users, while the OTP is generated for unauthorized members who can enter this area only if they have been allowed by authorized users to do so by giving them the OTP

Laparoscopic adjustable gastric banding – should a second chance be given?

Background: Obesity is a chronic relapsing-remitting disease and a global pandemic, being associated with multiple comorbidities. Laparoscopic adjustable gastric banding (LAGB) is one of the safest surgical procedures used for the treatment of obesity, and even though its popularity has been decreasing over time, it still remains an option for a certain group of patients, producing considerable weight loss and improvement in obesity-associated comorbidities. Methods: The aim of this study was to evaluate the impact of weight loss following LAGB on obesity-associated comorbidities, and to identify factors that could predict better response to surgery, and patient sub-groups exhibiting greatest benefit. A total of 99 severely obese patients (81.2% women, mean age 44.19 ± 10.94 years, mean body mass index (BMI) 51.84 ± 8.77 kg/m2) underwent LAGB in a single institution. Results obtained 1, 2, and 5 years postoperatively were compared with the pre-operative values using SPPS software version 20. Results: A significant drop in BMI was recorded throughout the follow-up period, as well as in A1c and triglycerides, with greatest improvement seen 2 years after surgery (51.8 ± 8.7 kg/m2 vs 42.3 ± 9.2 kg/m2, p < 0.05, 55.5 ± 19.1 mmol/mol vs 45.8 ± 13.7 mmol/mol, p < 0.05, and 2.2 ± 1.7 mmol/l vs 1.5 ± 0.6 mmol/l). Better outcomes were seen in younger patients, with lower duration of diabetes before surgery, and lower pre-operative systolic blood pressure. Conclusions: Younger age, lower degree of obesity, and lower severity of comorbidities at the time of surgery can be important predictors of successful weight loss, making this group of patients the ideal candidates for LAGB

Towards Low Latency and Resource-Efficient FPGA Implementations of the MUSIC Algorithm for Direction of Arrival Estimation

The estimation of the Direction of Arrival (DoA) is one of the most critical parameters for target recognition, identification and classification. MUltiple SIgnal Classification (MUSIC) is a powerful technique for DoA estimation. The algorithm requires complex mathematical operations like the computation of the covariance matrix for the input signals, eigenvalue decomposition and signal peak search. All these signal processing operations make real-time and resource-efficient implementation of the MUSIC algorithm on Field Programmable Gate Arrays (FPGAs) a challenge. In this paper, a novel design approach is proposed for the FPGA-implementation of the MUSIC algorithm. This approach enables a significant reduction in both FPGA resources and latency. In more detail, the proposed design enables the estimation of DoA in real-time scenarios in 2μ sec with 30% to 50% fewer resources as compared to existing techniques.The work of Pedro Reviriego was supported in part by the Architecting Intelligent Cost-effective Central Offices to enable 5G Tactile Internet (ACHILLES) through the Spanish Ministry of Economy and Competitivity under Project PID2019-104207RB-I00, in part by the Madrid Government (Comunidad de Madrid-Spain) through the Multiannual Agreement with Universidad Carlos III de Madrid (UC3M) in the line of Excellence of University Professors under Grant EPUC3M21, and in part by the Context of the V Plan Regional de Investigación Científica e Innovación Tecnológica (V PRICIT) (Regional Program of Research and Technological Innovation)

4-Nitro­phenyl 1-naphthoate

In the title compound, C17H11NO4, the dihedral angle between the two benzene rings is 8.66 (3)°. The nitro group is twisted by 4.51 (9)° out of the plane of the aromatic ring to which it is attached. The presence of inter­molecular C—H⋯O contacts in the crystal structure leads to the formation of chains along the c axis

Biochar affects growth and biochemical activities of fenugreek (Trigonella corniculata) in cadmium polluted soil

Cadmium (Cd) has no defined biological role and may enter the food chain from polluted soils. Biochar has been proposed as an organic amendment to minimize the toxic effects of Cd for plants grown on contaminated soils. In this study, biometric and biochemical attributes of fenugreek (Trigonella corniculata) grown on artificially cadmium (Cd) contaminated soil (0, 25, 50, 75 and 100 mg Cd/kg soil) at three levels of cotton-sticks derived biochar (CSB; 0, 3 and 5 %) were studied. Data show significant decline in the growth, photosynthetic pigments (chlorophyll a, b and total, carotenoids, anthocyanin and lycopene), and physiological attributes (sub-stomatal CO2 concentrations, photosynthetic and transpiration rate) in the presence of high Cd concentrations (50 and 100 mg Cd/kg soil). However, the decline was reduced in the presence of CSB. A steady amplification in lipid peroxidation (assessed via Malondialdihyde (MDA)) and ascorbic-acid assembly was noted with increasing Cd. The concentration of Cd in the root and shoot also decreased with increasing CSB application rates from 3 % - 5 %.Overall, the greater production of protein, amino acids and sugar contents in response to higher application rates of CSB seems to be due to alleviation in Cd toxicity. Thus, cotton-sticks can be safely utilized in the form of biochar as amendment with additional benefit of reducing Cd bioavailability and toxicity to crop plants