1,699 research outputs found
Origin and evolution of osmoregulatory mechanisms in blue-green algae as a function of metabolic and structural complexity: Reflections of precambrian paleobiology
Twenty-four of the twenty-nine cyanobacteria proposed for culture were successfully cultured. Betaines are discussed
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Classifying general nonlinear force laws in cell-based models via the continuum limit
though discrete cell-based frameworks are now commonly used to simulate a whole range of biological phenomena, it is typically not obvious how the numerous different types of model are related to one another, nor which one is most appropriate in a given context. Here we demonstrate how individual cell movement on the discrete scale modeled using nonlinear force laws can be described by nonlinear diffusion coefficients on the continuum scale. A general relationship between nonlinear force laws and their respective diffusion coefficients is derived in one spatial dimension and, subsequently, a range of particular examples is considered. For each case excellent agreement is observed between numerical solutions of the discrete and corresponding continuum models. Three case studies are considered in which we demonstrate how the derived nonlinear diffusion coefficients can be used to (a) relate different discrete models of cell behavior; (b) derive discrete, intercell force laws from previously posed diffusion coefficients, and (c) describe aggregative behavior in discrete simulations
Theory of commensurable magnetic structures in holmium
The tendency for the period of the helically ordered moments in holmium to
lock into values which are commensurable with the lattice is studied
theoretically as a function of temperature and magnetic field. The
commensurable effects are derived in the mean-field approximation from
numerical calculations of the free energy of various commensurable structures,
and the results are compared with the extensive experimental evidence collected
during the last ten years on the magnetic structures in holmium. In general the
stability of the different commensurable structures is found to be in accord
with the experiments, except for the tau=5/18 structure observed a few degrees
below T_N in a b-axis field. The trigonal coupling recently detected in holmium
is found to be the interaction required to explain the increased stability of
the tau=1/5 structure around 42 K, and of the tau=1/4 structure around 96 K,
when a field is applied along the c-axis.Comment: REVTEX, 31 pages, 7 postscript figure
Lieb's Theorem and Maximum Entropy Condensates
The maximum entropy steady states which form upon Floquet heating of the
ground state of the Hubbard model on unbalanced bi-partite lattices are shown
to possess uniform finite off-diagonal long-range order in the thermodynamic
limit. For repulsive interactions the induced order corresponds to the
formation of a spin-wave condensate, whilst for attractive interactions it
instead corresponds to the formation of a superconducting, -paired
condensate. This creation of a `hot' condensate can occur on any periodically
driven unbalanced lattice where the relevant SU(2) symmetry is preserved. Our
results provide an understanding of how strong driving can expose order which
has been suppressed by the lattice geometry - independent of any microscopic
parameters. We discuss the implications of this for recent experiments
observing emergent superconductivity in solid-state photoexcited compounds.Comment: 5 pages, 2 figures, comments are welcom
What is the impact of a peer counselling approach to help vulnerable children during lunchtimes?
There are many forms of peer support and collaboration projects and they are becoming increasingly popular throughout the world in both secondary and primary school. Peer counselling is individualised and palliative and this study examines the impact of four trained Year 5 and Year 6 counsellors on four Year 4 and Year 5 vulnerable, marginalised children with an extremely low sociometric status, who would become the focus group. The aim of the study was to increase prosocial interactions of the focus group. Sociometric testing was used before the project in order to identify the focus group and counsellors. Sociometric testing was used after the project to assess the impact of the intervention. Behavioural observations and questionnaires were also used to provide variable support for the projects effectiveness. Although two of the focus group left before the end of the project, the outcome was that positive interactions with peer counsellors and other children in the playground during lunchtimes very gradually increased. One child of the two remaining had a higher social status at the end of the project. Peer counselling proved a very useful model for a healthier world outside the classroom and a useful supplement to existing pastoral and inclusive strategies
Inter-annual tropical Pacific climate variability in an isotope-enabled CGCM: implications for interpreting coral stable oxygen isotope records of ENSO
Water isotope-enabled coupled atmosphere/ocean climate models allow for exploration of the relative contributions to coral stable oxygen isotope (&delta;<sup>18</sup>O<sub>coral</sub>) variability arising from Sea Surface Temperature (SST) and the isotopic composition of seawater (&delta;<sup>18</sup>O<sub>sw</sub>). The unforced behaviour of the isotope-enabled HadCM3 Coupled General Circulation Model affirms that the extent to which inter-annual &delta;<sup>18</sup>O<sub>sw</sub> variability contributes to that in model &delta;<sup>18</sup>O<sub>coral</sub> is strongly spatially dependent, ranging from being negligible in the eastern equatorial Pacific to accounting for 50% of &delta;<sup>18</sup>O<sub>coral</sub> variance in parts of the western Pacific. In these latter cases, a significant component of the inter-annual &delta;<sup>18</sup>O<sub>sw</sub> variability is correlated to that in SST, meaning that local calibrations of the effective local &delta;<sup>18</sup>O<sub>coral</sub>–SST relationships are likely to be essential. Furthermore, the relationship between &delta;<sup>18</sup>O<sub>sw</sub> and SST in the central and western equatorial Pacific is non-linear, such that the interpretation of model &delta;<sup>18</sup>O<sub>coral</sub> in the context of a linear dependence on SST alone may lead to overestimation (by up to 20%) of the SST anomalies associated with large El-Niño events. Intra-model evaluation of a salinity-based pseudo-coral approach shows that such an approach captures the first-order features of the model &delta;<sup>18</sup>O<sub>sw</sub> behaviour. However, the utility of the pseudo-corals is limited by the extent of spatial variability seen within the modelled slopes of the temporal salinity–&delta;<sup>18</sup>O<sub>sw</sub> relationship
The TGF-β Superfamily As Potential Therapeutic Targets in Pancreatic Cancer
The transforming growth factor (TGF)-β superfamily has important physiologic roles and is dysregulated in many pathologic processes, including pancreatic cancer. Pancreatic cancer is one of the most lethal cancer diagnoses, and current therapies are largely ineffective due to tumor resistance and late-stage diagnosis with poor prognosis. Recent efforts are focused on the potential of immunotherapies in improving therapeutic results for patients with pancreatic cancer, among which TGF-β has been identified as a promising target. This review focuses on the role of TGF-β in the diseased pancreas and pancreatic cancer. It also aims to summarize the current status of therapies targeting the TGF-β superfamily and postulate potential future directions in targeting the TGF-β signaling pathways
Fertilizer Impact on Groundwater in Utah
Water quality has become the focal point of many decisions involving crop production. Crop production depends on specific inputs including fertilizer application. Without proper fertilization a farmer cannot achieve maximum economic returns. Crop yields in Utah have been increased over 50% by nitrogen fertilizer application alone. However, increasing nitrogen application beyond that needed for optimum economic return does more harm than good. This is especially true when groundwater concerns are ressed
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