648 research outputs found
Accuracy of numerical relativity waveforms from binary neutron star mergers and their comparison with post-Newtonian waveforms
We present numerical relativity simulations of nine-orbit equal-mass binary
neutron star covering the quasicircular late inspiral and merger. The extracted
gravitational waveforms are analyzed for convergence and accuracy. Second order
convergence is observed up to contact, i.e. about 3-4 cycles to merger; error
estimates can be made up to this point. The uncertainties on the phase and the
amplitude are dominated by truncation errors and can be minimized to 0.13 rad
and less then 1%, respectively, by using several simulations and extrapolating
in resolution. In the latter case finite-radius extraction uncertainties become
a source of error of the same order and have to be taken into account. The
waveforms are tested against accuracy standards for data analysis. The
uncertainties on the waveforms are such that accuracy standards are generically
not met for signal-to-noise ratios relevant for detection, except for some best
cases using extrapolation from several runs. A detailed analysis of the errors
is thus imperative for the use of numerical relativity waveforms from binary
neutron stars in quantitative studies. The waveforms are compared with the
post-Newtonian Taylor T4 approximants both for point-particle and including the
analytically known tidal corrections. The T4 approximants accumulate
significant phase differences of 2 rad at contact and 4 rad at merger,
underestimating the influence of finite size effects. Tidal signatures in the
waveforms are thus important at least during the last six orbits of the merger
process.Comment: Physical Review D (Vol.85, No.10) 201
Letter by Kunz et al Regarding Article, "Systematic Review of the Cost and Cost-Effectiveness of Rapid Endovascular Therapy for Acute Ischemic Stroke"
The adaptive capacity of maize-based conservation agriculture systems to climate stress in tropical and subtropical environments: A meta-regression of yields
Conservation agriculture is widely promoted across sub-Saharan Africa as a sustainable farming practice that enhances adaptive capacity to climate change. The interactions between climate stress, management, and soil are critical to understanding the adaptive capacity of conservation agriculture. Yet conservation agriculture syntheses to date have largely neglected climate, especially the effects of extreme heat. For the sub-tropics and tropics, we use meta-regression, in combination with global soil and climate datasets, to test four hypotheses: (1) that relative yield performance of conservation agriculture improves with increasing drought and temperature stress; (2) that the effects of moisture and temperature stress exposure interact; (3) that the effects of moisture and temperature stress are modified by soil texture; and (4) that crop diversification, fertilizer application rate, or the time since no-till implementation will enhance conservation agriculture performance under climate stress. Our results support the hypothesis that the relative maize yield performance of conservation agriculture improves with increasing drought severity or exposure to high temperatures. Further, there is an interaction of moisture and heat stress on conservation agriculture performance and their combined effect is both non-additive and modified by soil clay content, supporting our second and third hypotheses. Finally, we found only limited support for our fourth hypothesis as (1) increasing nitrogen application rates did not improve the relative performance of conservation agriculture under high heat stress; (2) crop diversification did not notably improve conservation agriculture performance, but did increase its stability with heat stress; and (3) a statistically robust effect of the time since no-till implementation was not evident. Our meta-regression supports the narrative that conservation agriculture enhances the adaptive capacity of maize production in sub-Saharan Africa under drought and/or heat stress. However, in very wet seasons and on clay-rich soils, conservation agriculture yields less compared to conventional practices
Africa RISING science, innovations and technologies with scaling potential from ESA-Zambia
United States Agency for International Developmen
Prenatal mechanistic target of rapamycin complex 1 (mTORC1) inhibition by rapamycin treatment of pregnant mice causes intrauterine growth restriction and alters postnatal cardiac growth, morphology, and function
BACKGROUND: Fetal growth impacts cardiovascular health throughout postnatal life in humans. Various animal models of intrauterine growth restriction exhibit reduced heart size at birth, which negatively influences cardiac function in adulthood. The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and growth factor availability with cell growth, thereby regulating organ size. This study aimed at elucidating a possible involvement of mTORC1 in intrauterine growth restriction and prenatal heart growth.
METHODS AND RESULTS: We inhibited mTORC1 in fetal mice by rapamycin treatment of pregnant dams in late gestation. Prenatal rapamycin treatment reduces mTORC1 activity in various organs at birth, which is fully restored by postnatal day 3. Rapamycin-treated neonates exhibit a 16% reduction in body weight compared with vehicle-treated controls. Heart weight decreases by 35%, resulting in a significantly reduced heart weight/body weight ratio, smaller left ventricular dimensions, and reduced cardiac output in rapamycin- versus vehicle-treated mice at birth. Although proliferation rates in neonatal rapamycin-treated hearts are unaffected, cardiomyocyte size is reduced, and apoptosis increased compared with vehicle-treated neonates. Rapamycin-treated mice exhibit postnatal catch-up growth, but body weight and left ventricular mass remain reduced in adulthood. Prenatal mTORC1 inhibition causes a reduction in cardiomyocyte number in adult hearts compared with controls, which is partially compensated for by an increased cardiomyocyte volume, resulting in normal cardiac function without maladaptive left ventricular remodeling.
CONCLUSIONS: Prenatal rapamycin treatment of pregnant dams represents a new mouse model of intrauterine growth restriction and identifies an important role of mTORC1 in perinatal cardiac growth
Sustainable intensification of low-input agriculture systems in the Eastern Province of Zambia: implementation, progress and achievements
Conversion coefficients for superheavy elements
In this paper we report on internal conversion coefficients for Z = 111 to Z
= 126 superheavy elements obtained from relativistic Dirac-Fock (DF)
calculations. The effect of the atomic vacancy created during the conversion
process has been taken into account using the so called "Frozen Orbital"
approximation. The selection of this atomic model is supported by our recent
comparison of experimental and theoretical conversion coefficients across a
wide range of nuclei. The atomic masses, valence shell electron configurations,
and theoretical atomic binding energies required for the calculations were
adopted from a critical evaluation of the published data. The new conversion
coefficient data tables presented here cover all atomic shells, transition
energies from 1 keV up to 6000 keV, and multipole orders of 1 to 5. A similar
approach was used in our previous calculations [1] for Z = 5 - 110.Comment: Accepted for publication in Atomic Data and Nuclear Data Table
Dietary protein restriction throughout intrauterine and postnatal life results in potentially beneficial myocardial tissue remodeling in the adult mouse heart
Diet composition impacts metabolic and cardiovascular health with high caloric diets contributing to obesity related disorders. Dietary interventions such as caloric restriction exert beneficial effects in the cardiovascular system, but alteration of which specific nutrient is responsible is less clear. This study investigates the effects of a low protein diet (LPD) on morphology, tissue composition and function of the neonatal and adult mouse heart. Mice were subjected to LPD (8.8% protein) or standard protein diet (SPD, 22% protein) throughout intrauterine and postnatal life. At birth LPD female but not male offspring exhibit reduced body weight whereas heart weight was unchanged in both sexes. Cardiomyocyte cross sectional area was increased in newborn LPD females compared to SPD, whereas proliferation, cellular tissue composition and vascularization were unaffected. Adult female mice on LPD exhibit reduced body weight but normal heart weight compared to SPD controls. Echocardiography revealed normal left ventricular contractility in LPD animals. Histology showed reduced interstitial fibrosis, lower cardiomyocyte volume and elevated numbers of cardiomyocyte and non-myocyte nuclei per tissue area in adult LPD versus SPD myocardium. Furthermore, capillary density was increased in LPD hearts. In conclusion, pre- and postnatal dietary protein restriction in mice causes a potentially beneficial myocardial remodeling
A Short-Term Assessment of Carbon Dioxide Fluxes under Contrasting Agricultural and Soil Management Practices in Zimbabwe
Two of the biggest problems facing humankind are feeding an exponentially growing human population and preventing the accumulation of atmospheric greenhouse gases and its climate change consequences. Refined agricultural practices could address both of these problems. The research addressed here is an exploration of the efficacy of alternative agricultural practices in sequestering carbon (C). The study was conducted in Zimbabwe with the intent to (a) demonstrate the utility of micrometeorological methods for measuring carbon dioxide (CO2) exchange between the surface and the atmosphere in the short-term, and (b) to quantify differences in such exchange rates for a variety of agricultural practices. Four Bowen ratio energy balance (BREB) systems were established on the following agricultural management practices: (1) no-till (NT) followed by planting of winter wheat (Triticum aestivum), (2) NT followed by planting of blue lupin (Lupinus angustifolios L.), (3) maize crop residue (Zea mays L.) left on the surface, and (4) maize crop residue incorporated with tillage. Over a period of 139 days (from 15 June to 31 October 2013) the winter wheat cover crop produced a net accumulation of 257 g CO2-C m-2, while the tilled plot with no cover crop produced a net emission of 197 g CO2-C m-2 and the untilled plot with no cover emitted 235 g CO2-C m-2. The blue lupin cover crop emitted 58 g CO2-C m-2, indicating that winter cover crops can sequester carbon and reduce emissions over land left fallow through the non-growing season. The micrometeorological methods described in this work can detect significant differences between treatments over a period of a few months, an outcome important to determine which smallholder soil management practices can contribute towards mitigating climate change
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