Dynamical invariants and nonadiabatic geometric phases in open quantum systems

We introduce an operational framework to analyze non-adiabatic Abelian and non-Abelian, cyclic and non-cyclic, geometric phases in open quantum systems. In order to remove the adiabaticity condition, we generalize the theory of dynamical invariants to the context of open systems evolving under arbitrary convolutionless master equations. Geometric phases are then defined through the Jordan canonical form of the dynamical invariant associated with the super-operator that governs the master equation. As a by-product, we provide a sufficient condition for the robustness of the phase against a given decohering process. We illustrate our results by considering a two-level system in a Markovian interaction with the environment, where we show that the non-adiabatic geometric phase acquired by the system can be constructed in such a way that it is robust against both dephasing and spontaneous emission.Comment: 9 pages, 3 figures. v2: minor corrections and subsection IV.D added. Published versio

Highly sensitive terahertz measurement of layer thickness using a two-cylinder waveguide sensor

We report on the layer thickness determination on dielectrically coated metal cylinders using terahertz (THz) time-domain spectroscopy. A considerable sensitivity increase of up to a factor of 150 is obtained for layers down to 2.5 um thickness by introducing an experimental geometry based on a two-cylinder waveguide sensor. The layer attached on one metal cylinder is guided in contact with the second metal cylinder in the THz beam waist. This approach uses concepts of adiabatic THz wave compression and the advantages of THz waveguides. The results are compared to measurements on free-standing layers.Peer reviewedElectrical and Computer Engineerin

Minute-scale power forecast of offshore wind turbines using long-range single-Doppler lidar measurements

Decreasing gate closure times on the electricity stock exchange market and the rising share of renewables in today’s energy system causes an increasing demand for very short-term power forecasts. While the potential of dual-Doppler radar data for that purpose was recently shown, the utilization of single-Doppler lidar measurements needs to be explored further to make remote-sensing-based very short-term forecasts more feasible for offshore sites. The aim of this work was to develop a lidar-based forecasting methodology, which addresses a lidar's comparatively low scanning speed. We developed a lidar-based forecast methodology using horizontal plan position indicator (PPI) lidar scans. It comprises a filtering methodology to recover data at far ranges, a wind field reconstruction, a time synchronization to account for time shifts within the lidar scans and a wind speed extrapolation to hub height. Applying the methodology to seven free-flow turbines in the offshore wind farm Global Tech I revealed the model’s ability to outperform the benchmark persistence during unstable stratification, in terms of deterministic as well as probabilistic scores. The performance during stable and neutral situations was significantly lower, which we attribute mainly to errors in the extrapolation of wind speed to hub height

Terahertz two-cylinder waveguide coupler for transverse-magnetic and transverse-electric mode operation

We report the coupling and guiding of broadband terahertz radiation using a two-cylinder waveguide coupler. For the transverse electromagnetic TEM (TM0) geometry, the two opposing metal cylinders exhibit an amplitude transmission comparable to that of the cylindrical silicon lens coupled parallel-plate waveguide, but in the transverse-electric orientation the two-cylinder coupler shows much better amplitude transmission.Peer reviewedElectrical and Computer Engineerin

Adiabatic creation of coherent superposition states via multiple intermediate states

We consider an adiabatic population transfer process that resembles the well established stimulated Raman adiabatic passage (STIRAP). In our system, the states have nonzero angular momentums $J$, therefore, the coupling laser fields induce transitions among the magnetic sublevels of the states. In particular, we discuss the possibility of creating coherent superposition states in a system with coupling pattern $J=0\Leftrightarrow J=1$ and $J=1\Leftrightarrow J=2$. Initially, the system is in the J=0 state. We show that by two delayed, overlapping laser pulses it is possible to create any final superposition state of the magnetic sublevels $|2,-2>$, $|2,0>$, $|2,+2>$. Moreover, we find that the relative phases of the applied pulses influence not only the phases of the final superposition state but the probability amplitudes as well. We show that if we fix the shape and the time-delay between the pulses, the final state space can be entirely covered by varying the polarizations and relative phases of the two pulses. Performing numerical simulations we find that our transfer process is nearly adiabatic for the whole parameter set.Comment: 7 pages, 10 figure

Dry Cereals Fortified with Electrolytic Iron or Ferrous Fumarate Are Equally Effective in Breast-fed Infants

Precooked, instant (dry) infant cereals in the US are fortified with electrolytic iron, a source of low reactivity and suspected low bioavailability. Iron from ferrous fumarate is presumed to be more available. In this study, we compared a dry infant rice cereal (Cereal L) fortified with electrolytic iron (54.5 mg iron/100 g cereal) to a similar cereal (Cereal M) fortified with ferrous fumarate (52.2 mg Fe/100 g) for efficacy in maintaining iron status and preventing iron deficiency (ID) in breast-fed infants. Ascorbic acid was included in both cereals. In this prospective, randomized double-blind trial, exclusively breast-fed infants were enrolled at 1 mo and iron status was determined periodically. At 4 mo, 3 infants had ID anemia and were excluded. Ninety-five infants were randomized at 4 mo, and 69 (36 Cereal L, 33 Cereal M) completed the intervention at 9 mo. From 4 to 9 mo, they consumed daily one of the study cereals. With each cereal, 2 infants had mild ID, a prevalence of 4.2%, but no infant developed ID anemia. There were no differences in iron status between study groups. Iron intake from the study cereals was (mean ± SD) 1.21 ± 0.31 mg⋅kg−1⋅d−1 from Cereal L and 1.07 ± 0.40 mg⋅kg−1⋅d−1 from Cereal M. Eleven infants had low birth iron endowment (plasma ferritin < 55 μg/L at 2 mo) and 54% of these infants had ID with or without anemia by 4 mo. We conclude that electrolytic iron and ferrous fumarate were equally efficacious as fortificants of this infant cereal

Adiabatic population transfer via multiple intermediate states

This paper discusses a generalization of stimulated Raman adiabatic passage (STIRAP) in which the single intermediate state is replaced by $N$ intermediate states. Each of these states is connected to the initial state \state{i} with a coupling proportional to the pump pulse and to the final state \state{f} with a coupling proportional to the Stokes pulse, thus forming a parallel multi-$\Lambda$ system. It is shown that the dark (trapped) state exists only when the ratio between each pump coupling and the respective Stokes coupling is the same for all intermediate states. We derive the conditions for existence of a more general adiabatic-transfer state which includes transient contributions from the intermediate states but still transfers the population from state \state{i} to state \state{f} in the adiabatic limit. We present various numerical examples for success and failure of multi-$\Lambda$ STIRAP which illustrate the analytic predictions. Our results suggest that in the general case of arbitrary couplings, it is most appropriate to tune the pump and Stokes lasers either just below or just above all intermediate states.Comment: 14 pages, two-column revtex style, 10 figure

Plastic fiber design for THz generation through wavelength translation

We report on an all-fiber Terahertz (THz) radiation source by exploiting nonlinear parametric process in a theoretically designed microstructured-core double clad plastic fiber (MC-DCPF). The required phase-matching condition is satisfied through suitable tailoring of the fiber dispersion and nonlinear properties at the pump wavelength of a high power CO2 laser, with a CO laser of much lower power acting as a seed concomitantly. Our simulated results reveal that a THz radiation source at the frequency of ~ 3 THz could be realized with a 3-dB phase-matching band-width of 2.13 GHz in a 65 m long optimized MC-DCPF. Maximum power conversion efficiency >1% is realizable even after including the material loss

Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer

Endoglin, a transforming growth factor-beta co-receptor, is highly expressed on angiogenic endothelial cells in solid tumors. Therefore, targeting endoglin is currently being explored in clinical trials for anti-angiogenic therapy. In this project, the redundancy between endoglin and vascular endothelial growth factor (VEGF) signaling in angiogenesis and the effects of targeting both pathways on breast cancer metastasis were explored. In patient samples, increased endoglin signaling after VEGF inhibition was observed. In vitro TRC105, an endoglin-neutralizing antibody, increased VEGF signaling in endothelial cells. Moreover, combined targeting of the endoglin and VEGF pathway, with the VEGF receptor kinase inhibitor SU5416, increased antiangiogenic effects in vitro and in a zebrafish angiogenesis model. Next, in a mouse model for invasive lobular breast cancer, the effects of TRC105 and SU5416 on tumor growth and metastasis were explored. Although TRC105 and SU5416 decreased tumor vascular density, tumor volume was unaffected. Strikingly, in mice treated with TRC105, or TRC105 and SU5416 combined, a strong inhibition in the number of metastases was seen. Moreover, upon resection of the primary tumor, strong inhibition of metastatic spread by TRC105 was observed in an adjuvant setting. To confirm these data, we assessed the effects of endoglin-Fc (an endoglin ligand trap) on metastasis formation. Similar to treatment with TRC105 in the resection model, endoglin-Fc-expressing tumors showed strong inhibition of distant metastases. These results show, for the first time, that targeting endoglin, either with neutralizing antibodies or a ligand trap, strongly inhibits metastatic spread of breast cancer in vivo.Surgical oncolog

DNA copy number changes in young gastric cancer patients with special reference to chromosome 19

Only a few cytogenetic and genetic studies have been performed in gastric cancer patients in young age groups. In the present study we used the comparative genomic hybridisation (CGH) method to characterise frequent DNA copy number changes in 22 gastric cancer patients of 45 years or younger and three gastric cancer cell lines established from patients younger than 45 years. Analysis of DNA copy number changes revealed frequent DNA copy number increases at chromosomes 17q (52%), 19q (68%) and 20q (64%). To confirm the CGH results and to characterise the amplicon region on the most frequently amplified chromosome, chromosome 19, we carried out fluorescence in situ hybridisation (FISH) analysis and Southern blot analysis. Fluorescence in situ hybridisation with the bacterial artificial chromosome (BAC) clone mapped to 19q12 indicated a copy number increase in all eight tumour specimens studied. Southern blot analysis of six tumour specimens and three tumour cell lines, with five probes mapped to the 19q12-13.2 region, suggested cyclin E to be one of the candidate target genes in the 19q region for gastric cancer tumorigenesis. Cyclin E protein overexpression was verified in tumours with amplification on chromosome 19. Further studies are required to investigate the biological and clinical significance of 19q amplicon and cyclin E upregulation in gastric cancer of young patient