Pendugaan Umur Simpan Mi Instan Berbasis Tepung Jagung Lokal Riau dan Tapioka Menggunakan Metode Akselerasi

The purpose of this study was to determine the shelf life of instant noodles made from local corn flour with or without the addition of tapioca. This study was conducted experimentally using the Accelerated Storage Studies Method by keeping the products for 28 days at temperatures of 35ºC, 45ºC, 55ºC, the observed parameter organoleptic quality and TBA values. The results showed the self life of instant noodles made with or without the addition of tapioca were 39,552 days and 49,869 days, respectively

Coupling biochemistry and mechanics in cell adhesion: a model for inhomogeneous stress fiber contraction

Biochemistry and mechanics are closely coupled in cell adhesion. At sites of cell-matrix adhesion, mechanical force triggers signaling through the Rho-pathway, which leads to structural reinforcement and increased contractility in the actin cytoskeleton. The resulting force acts back to the sites of adhesion, resulting in a positive feedback loop for mature adhesion. Here we model this biochemical-mechanical feedback loop for the special case when the actin cytoskeleton is organized in stress fibers, which are contractile bundles of actin filaments. Activation of myosin II molecular motors through the Rho-pathway is described by a system of reaction-diffusion equations, which are coupled into a viscoelastic model for a contractile actin bundle. We find strong spatial gradients in the activation of contractility and in the corresponding deformation pattern of the stress fiber, in good agreement with experimental findings.Comment: Revtex, 35 pages, 13 Postscript figures included, in press with New Journal of Physics, Special Issue on The Physics of the Cytoskeleto

Matrix Elements of Random Operators and Discrete Symmetry Breaking in Nuclei

It is shown that several effects are responsible for deviations of the intensity distributions from the Porter-Thomas law. Among these are genuine symmetry breaking, such as isospin; the nature of the transition operator; truncation of the Hilbert space in shell model calculations and missing transitionsComment: 8 pages, 3 figure

Energy averages and fluctuations in the decay out of superdeformed bands

We derive analytic formulae for the energy average (including the energy average of the fluctuation contribution) and variance of the intraband decay intensity of a superdeformed band. Our results may be expressed in terms of three dimensionless variables: $\Gamma^{\downarrow}/\Gamma_S$, $\Gamma_N/d$, and $\Gamma_N/(\Gamma_S+\Gamma^{\downarrow})$. Here $\Gamma^{\downarrow}$ is the spreading width for the mixing of a superdeformed (SD) state $|0>$ with the normally deformed (ND) states $|Q>$ whose spin is the same as $|0>$'s. The $|Q>$ have mean level spacing $d$ and mean electromagnetic decay width $\Gamma_N$ whilst $|0>$ has electromagnetic decay width $\Gamma_S$. The average decay intensity may be expressed solely in terms of the variables $\Gamma^{\downarrow}/\Gamma_S$ and $\Gamma_N/d$ or, analogously to statistical nuclear reaction theory, in terms of the transmission coefficients $T_0(E)$ and $T_N$ describing transmission from the $|Q>$ to the SD band via $|0\angle$ and to lower ND states. The variance of the decay intensity, in analogy with Ericson's theory of cross section fluctuations depends on an additional variable, the correlation length \Gamma_N/(\Gamma_S+\Gamma^{\downarrow})=\frac{d}{2\pi}T_N/(\Gamma_S+\Gamma^{\d ownarrow}). This suggests that analysis of an experimentally obtained variance could yield the mean level spacing $d$ as does analysis of the cross section autocorrelation function in compound nuclear reactions. We compare our results with those of Gu and Weidenm\"uller.Comment: revtex4, 14 pages, 4 figures, to appear in Physical Review

Deformed Gaussian Orthogonal Ensemble Analysis of the Interacting Boson Model

A Deformed Gaussian Orthogonal Ensemble (DGOE) which interpolates between the Gaussian Orthogonal Ensemble and a Poissonian Ensemble is constructed. This new ensemble is then applied to the analysis of the chaotic properties of the low lying collective states of nuclei described by the Interacting Boson Model (IBM). This model undergoes a transition order-chaos-order from the $SU(3)$ limit to the $O(6)$ limit. Our analysis shows that the quantum fluctuations of the IBM Hamiltonian, both of the spectrum and the eigenvectors, follow the expected behaviour predicted by the DGOE when one goes from one limit to the other.Comment: 10 pages, 4 figures (avaiable upon request), IFUSP/P-1086 Replaced version: in the previous version the name of one of the authors was omitte

Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records

Bipolar disorder (BD) is a heritable mood disorder characterized by episodes of mania and depression. Although genomewide association studies (GWAS) have successfully identified genetic loci contributing to BD risk, sample size has become a rate-limiting obstacle to genetic discovery. Electronic health records (EHRs) represent a vast but relatively untapped resource for high-throughput phenotyping. As part of the International Cohort Collection for Bipolar Disorder (ICCBD), we previously validated automated EHR-based phenotyping algorithms for BD against in-person diagnostic interviews (Castro et al. Am J Psychiatry 172:363–372, 2015). Here, we establish the genetic validity of these phenotypes by determining their genetic correlation with traditionally ascertained samples. Case and control algorithms were derived from structured and narrative text in the Partners Healthcare system comprising more than 4.6 million patients over 20 years. Genomewide genotype data for 3330 BD cases and 3952 controls of European ancestry were used to estimate SNP-based heritability (h2g) and genetic correlation (rg) between EHR-based phenotype definitions and traditionally ascertained BD cases in GWAS by the ICCBD and Psychiatric Genomics Consortium (PGC) using LD score regression. We evaluated BD cases identified using 4 EHR-based algorithms: an NLP-based algorithm (95-NLP) and three rule-based algorithms using codified EHR with decreasing levels of stringency—“coded-strict”, “coded-broad”, and “coded-broad based on a single clinical encounter” (coded-broad-SV). The analytic sample comprised 862 95-NLP, 1968 coded-strict, 2581 coded-broad, 408 coded-broad-SV BD cases, and 3 952 controls. The estimated h2g were 0.24 (p = 0.015), 0.09 (p = 0.064), 0.13 (p = 0.003), 0.00 (p = 0.591) for 95-NLP, coded-strict, coded-broad and coded-broad-SV BD, respectively. The h2g for all EHR-based cases combined except coded-broad-SV (excluded due to 0 h2g) was 0.12 (p = 0.004). These h2g were lower or similar to the h2g observed by the ICCBD + PGCBD (0.23, p = 3.17E−80, total N = 33,181). However, the rg between ICCBD + PGCBD and the EHR-based cases were high for 95-NLP (0.66, p = 3.69 × 10–5), coded-strict (1.00, p = 2.40 × 10−4), and coded-broad (0.74, p = 8.11 × 10–7). The rg between EHR-based BD definitions ranged from 0.90 to 0.98. These results provide the first genetic validation of automated EHR-based phenotyping for BD and suggest that this approach identifies cases that are highly genetically correlated with those ascertained through conventional methods. High throughput phenotyping using the large data resources available in EHRs represents a viable method for accelerating psychiatric genetic research

New Constraints from PAMELA anti-proton data on Annihilating and Decaying Dark Matter

Recently the PAMELA experiment has released its updated anti-proton flux and anti-proton to proton flux ratio data up to energies of ~200GeV. With no clear excess of cosmic ray anti-protons at high energies, one can extend constraints on the production of anti-protons from dark matter. In this letter, we consider both the cases of dark matter annihilating and decaying into standard model particles that produce significant numbers of anti-protons. We provide two sets of constraints on the annihilation cross-sections/decay lifetimes. In the one set of constraints we ignore any source of anti-protons other than dark matter, which give the highest allowed cross-sections/inverse lifetimes. In the other set we include also anti-protons produced in collisions of cosmic rays with interstellar medium nuclei, getting tighter but more realistic constraints on the annihilation cross-sections/decay lifetimes.Comment: 7 pages, 3 figures, 3 table

Comorbidity of Severe Psychotic Disorders With Measures of Substance Use

Although early mortality in severe psychiatric illness is linked to smoking and alcohol, no studies have comprehensively characterized substance use behavior in severe psychotic illness. In particular, recent assessments of substance use in individuals with mental illness are based on population surveys that do not include individuals with severe psychotic illness

Assessment of metal and metalloid contamination in soils trough compositional data: the old Mortórios uranium mine area, central Portugal

Soils from the old Mortórios uranium mine area were studied to look for contamination, as they are close to two villages, up to 3 km away, and used for agriculture. They are mainly contaminated in U and As and constitute an ecological threat. This study attempts to outline the degree to which soils have been affected by the old mining activities through the computation of significant hot clusters, Traditional geostatistical approaches commonly use raw data (concentrations) accepting that the analyzed elements represent the soil’s entirety. However, in geochemical studies these elements are just a fraction of the total soil composition. Thus, considering compositional data is pivotal. The spatial characterization, considering raw and compositional data together, allowed a broad discussion about not only the concentrations’ spatial distribution, but also a better understanding on the possibility of trends of “relative enrichment” (RE) and, furthermore an insight in U and As fate. The highest proportions (Compositional data) on U (up to 33%), As (up to 35%) and Th (up to 13 %) are reached in the south-southeast segment. However, the highest concentrations (Raw data) occur in north and northwest of the studied area, pointing out to a “relative enrichment” towards the south-southeast zone. The Mondego Sul area is mainly contaminated in U and As, but also in Co, Cu, Pb and Sb. The Mortórios area is less contaminated than the Mondego Sul area.This research was supported by the Fundação para a Ciência e a Tecnologia through projects UID/ GEO/04035/201C and UID/MAR/04292/2013-MARE (PPC). Boente obtained a grant from the ‘‘Formación del Profesorado Universitario’’ program, financed by the ‘‘Ministerio de Educación, Cultura y Deporte de España.’’ M.T.D Albuquerque acknowledges a scholarship 567 SFRH/BSAB/ 127907/2016 from the Foundation for Science and Technology (Portugal)

Genetic Studies of Sulfadiazine-resistant and Methionine-requiring \u3cem\u3eNeisseria\u3c/em\u3e Isolated From Clinical Material

Deoxyribonucleate (DNA) preparations were extracted from Neisseria meningitidis (four isolates from spinal fluid and blood) and N. gonorrhoeae strains, all of which were resistant to sulfadiazine upon primary isolation. These DNA preparations, together with others from in vitro mutants of N. meningitidis and N. perflava, were examined in transformation tests by using as recipient a drug-susceptible strain of N. meningitidis (Ne 15 Sul-s Met+) which was able to grow in a methionine-free defined medium. The sulfadiazine resistance typical of each donor was introduced into the uniform constitution of this recipient. Production of p-aminobenzoic acid was not significantly altered thereby. Transformants elicited by DNA from the N. meningitidis clinical isolates were resistant to at least 200 μg of sulfadiazine/ml, and did not show a requirement for methionine (Sul-r Met+). DNA from six strains of N. gonorrhoeae, which were isolated during the period of therapeutic use of sulfonamides, conveyed lower degrees of resistance and, invariably, a concurrent methionine requirement (Sul-r/Met−). The requirement of these transformants, and that of in vitro mutants selected on sulfadiazine-agar, was satisfied by methionine, but not by vitamin B12, homocysteine, cystathionine, homoserine, or cysteine. Sul-r Met+ and Sul-r/Met− loci could coexist in the same genome, but were segregated during transformation. On the other hand, the dual Sul-r/Met− properties were not separated by recombination, but were eliminated together. DNA from various Sul-r/Met− clones tested against recipients having nonidentical Sul-r/Met− mutant sites yielded Sul-s Met+ transformants. The met locus involved is genetically complex, and will be a valuable tool for studies of genetic fine structure of members of Neisseria, and of genetic homology between species