11,060 research outputs found
Gyroscopic control of a rigid body constrained to rotate about a fixed axis
Gyroscopic control of spin rate or orientation of rigid bodies constrained to rotate about fixed axi
Pitch and yaw motions of a human being in free fall
Human limb motions for body orientation during free fal
Alteration of the state of motion of a human being in free fall
Orientation and attitude alteration of human body motion state in free fall studied with mathematical model
Regulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiae
In the budding yeast Saccharomyces cerevisiae, the Cdc42 effector Ste20 plays a crucial role in the regulation of filamentous growth, a response to nutrient limitation. Using the split-ubiquitin technique, we found that Ste20 forms a complex with Vma13, an important regulatory subunit of vacuolar H(+)-ATPase (V-ATPase). This protein-protein interaction was confirmed by a pulldown assay and coimmunoprecipitation. We also demonstrate that Ste20 associates with vacuolar membranes and that Ste20 stimulates V-ATPase activity in isolated vacuolar membranes. This activation requires Ste20 kinase activity and does not depend on increased assembly of the V1 and V0 sectors of the V-ATPase, which is a major regulatory mechanism. Furthermore, loss of V-ATPase activity leads to a strong increase in invasive growth, possibly because these cells fail to store and mobilize nutrients efficiently in the vacuole in the absence of the vacuolar proton gradient. In contrast to the wild type, which grows in rather small, isolated colonies on solid medium during filamentation, hyperinvasive vma mutants form much bigger aggregates in which a large number of cells are tightly clustered together. Genetic data suggest that Ste20 and the protein kinase A catalytic subunit Tpk2 are both activated in the vma13Δ strain. We propose that during filamentous growth, Ste20 stimulates V-ATPase activity. This would sustain nutrient mobilization from vacuolar stores, which is beneficial for filamentous growth.The project was supported by Deutsche Forschungsgemeinschaft grant HO 2098/3 to T.H. and NIH grant R01 GM50322 to P.M.K
High-Field Electrical Transport in Single-Wall Carbon Nanotubes
Using low-resistance electrical contacts, we have measured the intrinsic
high-field transport properties of metallic single-wall carbon nanotubes.
Individual nanotubes appear to be able to carry currents with a density
exceeding 10^9 A/cm^2. As the bias voltage is increased, the conductance drops
dramatically due to scattering of electrons. We show that the current-voltage
characteristics can be explained by considering optical or zone-boundary phonon
emission as the dominant scattering mechanism at high field.Comment: 4 pages, 3 eps figure
Analysis of heavy spin--3/2 baryon--heavy spin--1/2 baryon--light vector meson vertices in QCD
The heavy spin--3/2 baryon--heavy spin--1/2 baryon vertices with light vector
mesons are studied within the light cone QCD sum rules method. These vertices
are parametrized in terms of three coupling constants. These couplings are
calculated for all possible transitions. It is shown that correlation functions
for these transitions are described by only one invariant function for every
Lorenz structure. The obtained relations between the correlation functions of
the different transitions are structure independent while explicit expressions
of invariant functions depend on the Lorenz structure.Comment: 17 Pages, 6 Figures and 4 Table
The Fractional Quantum Hall effect in an array of quantum wires
We demonstrate the emergence of the quantum Hall (QH) hierarchy in a 2D model
of coupled quantum wires in a perpendicular magnetic field. At commensurate
values of the magnetic field, the system can develop instabilities to
appropriate inter-wire electron hopping processes that drive the system into a
variety of QH states. Some of the QH states are not included in the
Haldane-Halperin hierarchy. In addition, we find operators allowed at any field
that lead to novel crystals of Laughlin quasiparticles. We demonstrate that any
QH state is the groundstate of a Hamiltonian that we explicitly construct.Comment: Revtex, 4 pages, 2 figure
Photoaversion in inherited retinal diseases: clinical phenotypes, biological basis, and qualitative and quantitative assessment
Severe light sensitivity is a feature common to a range of ophthalmological and neurological diseases. In
inherited retinal diseases (IRDs) particularly, this may be accompanied by significant visual disruption. These
symptoms are extremely debilitating for affected individuals and have significant implications in terms
of day-to-day activities. Underlying mechanisms remain to be fully elucidated. Currently, there are many
assessments of photoaversion (PA), however, all have limitations, with quantitative measurement in particular needing further evaluation. To understand the complexities associated with photoaversion from
different pathologies, qualitative and quantitative assessments of the light aversion response must be
standardized. There is no treatment to date, and strategies to alleviate symptoms focus on light avoidance.
With respect to IRDs, however, gene therapy is currently being investigated in clinical trials and promising
and further treatments may be on the horizon. The better characterization of these symptoms is an
important end point measure in IRD gene therapy trials
Fluvoxamine for aripiprazole-associated akathisia in patients with schizophrenia: a potential role of sigma-1 receptors
<p>Abstract</p> <p>Background</p> <p>Second-generation antipsychotic drugs have been reported to cause fewer incidences of extrapyramidal side effects (EPSs) than typical antipsychotic drugs, but adverse events such as akathisia have been observed even with atypical antipsychotic drugs. Although understanding of the pathophysiology of akathisia remains limited, it seems that a complex interplay of several neurotransmitter systems might play a role in its pathophysiology. The endoplasmic reticulum protein sigma-1 receptors are shown to regulate a number of neurotransmitter systems in the brain.</p> <p>Methods</p> <p>We report on two cases in which monotherapy of the selective serotonin reuptake inhibitor and sigma-1 receptor agonist fluvoxamine was effective in ameliorating the akathisia of patients with schizophrenia treated with the antipsychotic drug aripiprazole.</p> <p>Results</p> <p>The global score on the Barnes Akathisia Scale in the two patients with schizophrenia treated with aripiprazole decreased after fluvoxamine monotherapy.</p> <p>Conclusion</p> <p>Doctors may wish to consider fluvoxamine as an alternative approach in treating akathisia associated with antipsychotic drugs such as aripiprazole.</p
The HD 192263 system: planetary orbital period and stellar variability disentangled
As part of the Transit Ephemeris Refinement and Monitoring Survey (TERMS), we
present new radial velocities and photometry of the HD 192263 system. Our
analysis of the already available Keck-HIRES and CORALIE radial velocity
measurements together with the five new Keck measurements we report in this
paper results in improved orbital parameters for the system. We derive
constraints on the size and phase location of the transit window for HD
192263b, a Jupiter-mass planet with a period of 24.3587 \pm 0.0022 days. We use
10 years of Automated Photoelectric Telescope (APT) photometry to analyze the
stellar variability and search for planetary transits. We find continuing
evidence of spot activity with periods near 23.4 days. The shape of the
corresponding photometric variations changes over time, giving rise to not one
but several Fourier peaks near this value. However, none of these frequencies
coincides with the planet's orbital period and thus we find no evidence of
star-planet interactions in the system. We attribute the ~23-day variability to
stellar rotation. There are also indications of spot variations on longer (8
years) timescales. Finally, we use the photometric data to exclude transits for
a planet with the predicted radius of 1.09 RJ, and as small as 0.79 RJ.Comment: 9 pages, 6 tables, 6 figures; accepted to Ap
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