Quality of milk and dairy products under traditional smallholder system in northern Ethiopia

In Ethiopia, goats represent an important component of the farming system. In Abergelle, goats make the highest contribution to farmers' livelihoods, compared with other agricultural enterprises. Processing of traditional dairy products is an important activity by women that contribute to the nutrition and livelihood of the family. The main products are Kibe; local butter, Ergo; local fermented milk and Arera. However, hygienic conditions are often poor and milking practices are conducive to contamination. Farmers' local knowledge on traditional processing methods were assessed through a survey conducted in eight villages in Abergelle regions using a structured questionnaire aiming to collect data on milk production, processing and hygienic practices, to develop a safer, low-cost processing technologies. In total 375 households were surveyed. It was found that Ergo is mainly consumed by the family whereas Kibe is the main sold product for 44% households. However, processing Kibe is labour intensive 12%. Moreover, farmers are facing problems related to product quality. Due to hygiene conditions, product spoilage was observed in 28% of the farms. Product taste is attributed to proper cleaning and fumigation of the milk container with Ekema wood 43%, and 6% of households reported a problem of appearance due to elevated acidity of Ergo. Moreover, 91 samples of goat milk and milk products were collected. Analysis of milk components showed a big variation in composition. Fat content that is important for butter production was varying from 2.8-9.9%. Almost 60% of analysed milk samples tended to become acidic due to high microbial load. In addition, alkaline milk was observed in some farms indicating mastitis, which is confirmed by elevated values of electric conductivity, up to 7.3mS/cm. Samples found to have a prevalence of 5.4% of Staphylococcus aureus and 8.7% of E. coli. The standard plate count for 79% of the samples was ≥10^6, indicating a serious deficiencies in production hygiene. The quality of raw milk is a challenge for milk processing, and there is a need to focus on goat husbandry and management to produce healthy milk. Improving processing practices and hygiene is crucial to overcome constraints and enhance the livelihood of households

Nitric Oxide Signaling Modulates Synaptic Transmission during Early Postnatal Development

Early γ-aminobutyric acid mediated (GABAergic) synaptic transmission and correlated neuronal activity are fundamental to network formation; however, their regulation during early postnatal development is poorly understood. Nitric oxide (NO) is an important retrograde messenger at glutamatergic synapses, and it was recently shown to play an important role also at GABAergic synapses in the adult brain. The subcellular localization and network effect of this signaling pathway during early development are so far unexplored, but its disruption at this early age is known to lead to profound morphological and functional alterations. Here, we provide functional evidence—using whole-cell recording—that NO signaling modulates not only glutamatergic but also GABAergic synaptic transmission in the mouse hippocampus during the early postnatal period. We identified the precise subcellular localization of key elements of the underlying molecular cascade using immunohistochemistry at the light—and electron microscopic levels. As predicted by these morpho-functional data, multineuron calcium imaging in acute slices revealed that this NO-signaling machinery is involved also in the control of synchronous network activity patterns. We suggest that the retrograde NO-signaling system is ideally suited to fulfill a general presynaptic regulatory role and may effectively fine-tune network activity during early postnatal development, while GABAergic transmission is still depolarizing

Women's labour, kinship, and economic changes in Jinmen in the era of authoritarian rule

This article uses the life stories of three women in Jinmen to demonstrate women’s economic agency in bettering the livelihood of their families in circumstances largely shaped by Cold War geopolitics and the authoritarian state’s military strategies. It argues that women’s devotion of their labour and earnings to their families was part of the reproductive processes of the kinship system, but also important to their building of social reputation and emotional ties with their loved ones. Moreover, the state’s campaign to protect traditional Chinese culture, framed within bipolar politics, supported the ideological reproduction of women’s primary roles being in the domestic sphere. While the lives of Jinmen civilians were significantly distorted in the Cold War era, their experiences of economic improvement and a certain stability in their ways of life – revolving around kinship – account for the ambivalence they now feel towards the period of authoritarian rule

Median raphe region stimulation alone generates remote, but not recent fear memory traces

The median raphe region (MRR) is believed to control the fear circuitry indirectly, by influencing the encoding and retrieval of fear memories by amygdala, hippocampus and prefrontal cortex. Here we show that in addition to this established role, MRR stimulation may alone elicit the emergence of remote but not recent fear memories. We substituted electric shocks with optic stimulation of MRR in C57BL/6N male mice in an optogenetic conditioning paradigm and found that stimulations produced agitation, but not fear, during the conditioning trial. Contextual fear, reflected by freezing was not present the next day, but appeared after a 7 days incubation. The optogenetic silencing of MRR during electric shocks ameliorated conditioned fear also seven, but not one day after conditioning. The optogenetic stimulation patterns (50Hz theta burst and 20Hz) used in our tests elicited serotonin release in vitro and lead to activation primarily in the periaqueductal gray examined by c-Fos immunohistochemistry. Earlier studies demonstrated that fear can be induced acutely by stimulation of several subcortical centers, which, however, do not generate persistent fear memories. Here we show that the MRR also elicits fear, but this develops slowly over time, likely by plastic changes induced by the area and its connections. These findings assign a specific role to the MRR in fear learning. Particularly, we suggest that this area is responsible for the durable sensitization of fear circuits towards aversive contexts, and by this, it contributes to the persistence of fear memories. This suggests the existence a bottom-up control of fear circuits by the MRR, which complements the top-down control exerted by the medial prefrontal cortex

On leaf magnetic homogeneity in particulate matter biomonitoring

Biomonitoring of magnetic properties of tree leaves has been postulated to be a good approach to measure particulate matter (PM) pollution levels. We studied the variation of magnetic hysteresis parameters on leaves of Quercus ilex, an evergreen oak previously used for magnetic biomonitoring of air pollution in Rome (Italy). The hysteresis parameters (MRS, MS, BCR and BC) measured on specimens collected at a close spacing on the surface of two single leaves show variances that are smaller than those observed on a collection of Q. ilex leaves sampled from several trees distributed along high-traffic roads. The variability is higher for magnetizations than for coercivities. This suggests a uniform source for the magnetic particles, such that variations are due mainly to changes in concentration. The normalized hysteresis cycles are remarkably similar for all the specimens. Normalization of magnetic moments by mass appears however more efficient than normalization by volume

Management with continence products

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Systematic review and meta-analysis of metacestode prevalence in small ruminants in Ethiopia

Metacestode, larval stages of canid cestode parasites are among the causes of morbidity, mortality and financial losses in small ruminants in Ethiopia as a result of organ and carcass condemnation at slaughter. Several studies have been conducted over the years; however, these studies often had limited scope and coverage. This systematic review and meta-analysis was conducted to collate the information so far available in order to provide a pooled prevalence estimate at national level and identify potential predictors. Published and gray literature written in English and Amharic during the period between, 1st of January, 1990 and June 25, 2015 were searched from electronic databases and repositories of academic and research institutions. Relevant animal level data on 67,743 small ruminants was extracted from 23 published articles and one master’s thesis resulting altogether in 86 animal level reports that conformed to predefined criteria. The dataset was analyzed using a meta-analytical approach. The pooled prevalence estimate computed for metacestodes infection was 11.8% with a 95% confidence interval (CI) of 9.0, 15.2. The highest prevalence estimate 31.2% (95% CI: 23.1, 40.9) was found for Cysticercus tenuicollis (Taenia hydatigena) followed by cystic echinococcosis (Echinococcus granulosus) 8.8% (95% CI: 5.8, 13.1), Cysticercus ovis(Taenia ovis) 4.9% (95% CI: 2.9, 9.4) and Coenurus cerebralis (Taenia multiceps) 4.6% (95% CI: 1.6, 12.2). Among the predictors considered for heterogeneity analysis only sample size and metacestode type fitted the final multivariable meta-regression model and explained 26.3% of the explainable heterogeneity between studies (p0.05). In conclusion, this review showed a widespread occurrence of metacestodes in small ruminants in Ethiopia. Thus, a holistic approach to break the life cycle of these parasitic stages is suggested, including regulatory interventions that encourage dog owners to keep their dogs confined and prevent backyard slaughter and proper management of abattoir waste disposal

Gastrointestinal nematode infection in small ruminants in Ethiopia: A systematic review and meta-analysis

Gastrointestinal (GI) nematode infections are a major health challenge affecting productive and reproductive performance of sheep and goats in Ethiopia. However, there is no comprehensive summary on the occurrence and distribution of the infection at national level. This systematic review provides pooled prevalence estimates and assesses potential predictors of the nematode infections in small ruminants, i.e. helpful in planning interventions or control strategies. The review used 50 animal level datasets retrieved from 24 manuscripts. The studies used data collected from 9407 sheep and 3478 goats. A meta-analytical approach was employed to analyze Effect size (ES). The reported GI nematodes represented eleven genera affecting sheep and goats including:Haemonchus, Trichostrongylus, Teladorsagia/Ostertagia, Strongyloides, Bunostomum,Nematodirus, Chabertia, Trichuris, Cooperia, Skrjabinema and Oesophagostomum. The GI nematodes pooled prevalence estimate in the random effect model was 75.8% (95% CI: 69.6, 80.8). The subgroup analysis revealed significant (p < 0.05) differences in the prevalence between different regions and type of diagnostic methods used. ‘Postmortem technique’ and ‘eastern part of the country’ were associated with higher GI nematode prevalence and accounted for 68.1% of the between studies heterogeneity. In light of the high parasitic prevalence in all agro-ecologies, the need for strategic intervention is recommended. Meanwhile, data need to be generated for some of the regions where dependable survey reports are lacking