A Hybrid of Improved Bulls and Weighted Round Robin to optimize the Leader and Load Balancing in Cloud and Distributed Computing Environment

Day by Day there is increase of internet users which leads to increase the traffic in the network which causing the generation of huge data. It requires the balancing of network load on the network servers with different Load balancing techniques. It is also required to have efficient algorithm to analysis the huge data in distributed manner to identify the leader to act as centralized point of contact for services. If we audit on the heap adjusting systems, there are a few potential outcomes to upgrade the methods. In the present scenario, we have the methods, round robin algorithm (static load adjusting), Weighted Round Robin algorithm and Least Load algorithm (Dynamic Load Balancing). A researcher D. Chitra Devi .et .al has given the idea of enhanced weighted round robin algorithm (EWRR) which gives much better reaction when contrasted with basic round robin calculation. Another scholar Rashmi Saini et. al recommended the half breed of round robin calculation and minimum Load Algorithm. From the above scholars� articles, I hereby propose a resolution by improved Bulls algorithm along with Weighted Round Robin (WRR) algorithm to achieve high performance in Distributed and Cloud Computing domain in terms of leader election from a group of distributed and non-failed processes, load balancing dynamically and coordinate other nodes. Bulls algorithm uses the following message types: � Election Message: Sent to announce election. � Answer (Alive) Message: Responds to the Election message. � Coordinator (Victory) Message: Sent by winner of the election to announce victory. When coordinator fails to recover a process P, from failure or detecting before failure, the process P performs the following actions: 1. If P has the highest process id, it sends a Victory message to all other processes and becomes the new Coordinator. Otherwise, P broadcasts an Election message to all other processes with higher process IDs than itself. 2. If P does not receive any Election message, then it broadcasts a Victory message to all other processes and becomes the Coordinator. 3. If P receives an Answer from a process with a higher ID, it sends no further messages for this election and waits for a Victory message. When there is no Victory message after a stipulated period, it restarts the process from the beginning. 4. If P receives an Election message from another process with a lower ID it sends an Answer message back and starts the election process at the beginning, by sending an Election message to higher-numbered processes. 5. If P receives a Coordinator message, it treats the sender as the coordinator

Parent involvement towards children’s reading habit: A focus group survey from Nashik, India

Abstract Purpose - This study was carried out to ascertain parents’ attitude about reading related activities of children, to discover parents’ efforts for instilling the reading habit in their children, to understand the challenges faced by parents in inculcating reading habit in their children, and to suggest possible solutions to the parents’ difficulties related to their children’s reading habits. Design/ Methodology - The research was conducted using the Survey method, with Focus Group Discussion used as the data collection tool. The research sample was 24 parents of pupils who were studying in the primary and secondary Marathi medium schools in Nashik district. An anonymous data was collected Qualitative descriptive analysis was carried out of the collected data. Findings - It was observed that parents knew that pleasure reading was important for the overall behavioral development of their children. However, less than half of them performed any substantial activities to instill the reading habit in their children. Children’s excessive usage of the internet, time constraints, children’s disinterest in reading, and parents’ incognizance about the effective reading material were the main challenges faced. Originality/ Value - This study is one of the first one of its kind in the Indian scenario. Uniquely collecting parents’ real experiences through focus group interviews, this paper provides concrete solutions to the difficulties of parents in inculcating reading habits among their children. Paper type - Research pape

Cutaneous mastocytosis. Getting beneath the skin of the issue: a case report

An eleven month old girl presented with chronic urticaria since three months of age. There was a generalised hyperpigmented maculo-papular rash. Darier sign was positive. The skin biopsy showed plenty of spindle shaped mast cells with eosinophilic cytoplasm infiltrating the dermis and the appendiceal structures. The diagnosis of cutaneous mastocytosis (urticaria pigmentosa) was made. The child received symptomatic relief with chronic oral hydroxyzine and ranitidine therapy. Automated epinephrine self-injectors usually prescribed in this condition for self-management of anaphylactic episodes were not available. Intramuscular administration of (1:1000) diluted adrenaline via a disposable tuberculin syringe was taught to the mother. A medical bracelet containing her diagnosis and instructions in emergency was custom-made for her

Ofloxacin-induced maculopapular rash in the infant

Adverse drug reactions (ADRs) are a major cause of morbidity and mortality in countries having limited healthcare resources. The ofloxacin is an antimicrobial used for treating several bacterial infections. The ofloxacin, belonging to quinolone group of drugs, is bactericidal and acts by inhibition of bacterial DNA gyrase. Among the adverse drug reaction of ofloxacin, skin rashes are rare. An ofloxacin-induced maculopapular rash is the unique rare condition in the infant. The present case report was assessing the causality in ofloxacin induced maculopapular rash in the infant. Naranjo Adverse Drug Reaction Probability Scale and World Health Organization and Uppsala Monitoring Centre (WHO-UMC) system for standardized case causality assessment were used for assessing the causality. According to the Naranjo and WHO-UMC, ofloxacin scaled as the probable/likely cause of this ADR in infant. So, authors can conclude that the ofloxacin should be used cautiously in the pediatric age group

Data Mining and Social Media for promotion and marketing in the Aerospace Industry

Data mining and social media is an innovative platform for the aerospace industry to focus, promote and market the industry in the upcoming economy. Data mining techniques allow the industry to build a comprehensive system that helps to make intelligent management decisions in a formal system. On the other hand Social Media is used as a tool to ensure maximum return by entering a hybrid media landscape, one where the rapid growth of Social Media complements and enhances the efficiency of the industry. By using trend analysis this research would showcase benefits that the industry will achieve by increasing their profit margins and market competiveness. This research mainly focuses on supporting the aerospace industry to build trust among customers and meeting demand specifications by using data mining techniques and social media platform

MUCOADHESIVE POLYMERIC FILMS OF ACYCLOVIR PRONIOSOMES FOR BUCCAL ADMINISTRATION

Objective: The aim of the present work was to formulate and evaluate proniosomes of the poorly soluble drug, acyclovir incorporated in mucoadhesive polymeric films for improved buccal mucosal permeability of the drug while achieving prolonged release. Methods: Acyclovir was formulated as proniosomes using Span 60 and cholesterol. The prepared proniosomes were loaded into mucoadhesive polymeric films prepared with varying quantities of carbopol 934P and HPMC K15M. The proniosome incorporated films were evaluated for physicomechanical characters, mucoadhesion, swelling index, drug content, in vitro drug release and ex vivo permeation through porcine buccal mucosa. Results: Hydration of the proniosomes produced spherical vesicles or niosomes, which was confirmed by Scanning Electron Microscopy. The optimized formulation selected on the basis of vesicle size, entrapment efficiency PDI, Zetz potential and in vitro drug release was selected for incorporation into mucoadhesive polymeric films. All the films showed excellent physicomechanical characters. Formulations with higher proportions of carbopol produced slower in vitro drug release. The kinetics of release of drug from all the formulations appeared to be zero-order based on their regression coefficient values. Comparative evaluation of ex vivo permeation from niosomal and non-niosomal films indicated that the former demonstrated improved mucosal permeation and drug release was also sustained for the 8 h period. Conclusion: Mucoadhesive films impregnated with acyclovir loaded proniosomes could be a potential approach for buccal delivery of acyclovir for improving its absorption and bioavailability.&nbsp

A Literature Review on various Ayurveda Dosage forms

Ayurvedic medicines are intended for internal and external use, for or in the diagnosis, treatment, mitigation or prevention of disease or disorder in human beings or animals. Traditional medicine is finding more significance and application today, particularly when we are facing difficulty in the management of numerous medical conditions. Ayurveda is an ancient system of medical science which elucidates about the different forms of dosage, which is the physical form of a medication deliberate for administration. As per Ayurveda the different types of dosage forms can be prepared by the Vaidya (physician) according to Yukti (solution by scientific logic), Seeing Samyog, Vishesha, Kala and Samskara. Different types of dosage forms have been described in the Ayurvedic text. These all are classified in to different types such as Aushadha Kalpana, Aahara Kalpana, and Bahya and Abhyantara Kalpana, including solid, liquid and semisolid forms, As well as their sources also such as plant, animal and mineral origin. The Dosage forms are mainly pre medicated to increase shelf life, palatability and to potency. These all can be used for both purposes internally and externally. Few of the dosage forms of them have been described mainly based on the physical mode of medicine, its uses and advantages

SYNTHESIS OF QUINOLINYL-OXADIAZOLE AS A POTENT ANTIBACTERIAL AGENT AND SA-FABI INHIBITOR

Objective: Microbial resistance to currently marketed drugs is a serious problem worldwide and there is a vital need to develop novel antibiotics. Enoyl-ACP reductase (FabI) is essential for fatty acid biosynthesis and hence serves as an appealing target for antibacterials against methicillin resistant S. aureus. The present study focuses on the synthesis, antibacterial and saFab1 docking studies of three new series of quinoline derivatives: 5-[(quinolin-8-yloxy) methyl]-1,3,4-oxadiazole-2(3H)-thiones, N-(2,5-dimethyl-1H-pyrrol-1-yl)-2oxyacetamides and 2-(oxyacetyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-ones with integrated ether linkages.Methods: Three different substituted hydrazides were synthesized from substituted quinolinols. These hydrazides were allowed to undergo further reactions with carbon disulphide, 2,5-hexanedione and ethyl acetoacetate respectively to prepare 1,3,4-oxadiazole-2-thiones, N-substituted pyrrole acetamides and pyrazol-3-ones. The synthesized hydrazide derivatives were subjected to antimicrobial studies against Staphylococcus aureus. Docking studies were carried out using enoyl-ACP reductase crystal structure complexed with NADPH.Results: 5-{[(2-methylquinolin-8-yl) oxy] methyl}-1, 3, 4-oxadiazole-2(3H)-thione (2b) with a methyl substituent on the quinoline ring was found to display significant antibacterial potential against S. aureus. Good binding interactions were observed in subsequent docking studies via formation of Fab1-NAD+-2b ternary complex through hydrogen bonding and stacking interactions.Conclusion: 1, 3, 4-oxadiazole-2(3H)-thione (2b) was found to exhibit promising antibacterial potential against S. aureus.Â

Concept & utility of Nanotechnology in the standardization of Rasadravya

The ancient application of nanomedicine in the form of Ayurvedic Bhasma throws a light on the safer usage of present nanomedicine for a living being and the environment. The use of nanoparticulate metals in therapeutics has been a common practice in Ayurveda. All Bhasma have some common properties such as Rasayana (immunomodulation & anti-aging quality), Yogavahi (target drug delivery), Alpamatra (prescribed in minute doses), Shigravyapi (spreads quickly and fast acting) and Agnideepana (increases metabolism at cellular level and acts as catalyst). Bhasma can be employed for selective/ targeted/controlled drug delivery as they are biocompatible, nontoxic, and nonantigenic in nature. Bhasma is biologically produced nanoparticles with quick and targeted action. E.g Gold nanoparticles in Swarna Bhasma. Ayurvedic Bhasma is considered very safe and economical in comparison to contemporary metal based nanomedicines. The benefits of nanomedicines are indubitable and unstoppable, nevertheless, and safety- related studies should also be carried out rigorously and planned in order to provide guidelines for safer manufacturing practices, keeping care of ecology, and environment. Hence, Ayurvedic Bhasma may hold strong relevance in the emerging era of nanomedicine and can serve as an excellent template for the development of nanomedicine for an efficient therapeutic cure

Functional recovery in a rare case of an adult patient with leucodystrophy

The adulthood leukodystrophy is an uncommon clinical condition. Physiotherapy treatment provided to this referred patient resulted in a significant functional recovery within a short span of time inspite of gross lesion. A 34-year-old male patient diagnosed as a case of leucodystrophy was referred for Physiotherapy after 2 years of initial diagnosis physiotherapy progress consisted of increasing muscle strength, reducing tightness and improving postural stability; also to improve mobility for 5 months. After taking the pre and post assessment values of MAS, FIST, mFRT and FIM, improvement through the post assessment values showed significant functional recovery within 5 months. Significant functional recovery after 2 years of diagnosis of leucodystrophy provides promising scope of physiotherapy in future cases of leucodystrophy