37 research outputs found
Efficient construction of the kedarcidin chromophore ansamacrolide
Get PDFThe streamlined assembly of the ansamacrolide framework of the kedarcidin chromophore via an efficient atropselective Sonogashira coupling step is described. To this end, two newly improved practical syntheses of the cyclopentene and dine fragments have been developed, which feature 0.2 mol % catalytic loadings for an RCM step and i-PrMgCl/CH2I2 as a new entry to gem-disubstituted epoxides from ketones, both being applicable to 49-g scales
Versatile Approach to Enantiopure 2, 6-Disubstituted Piperidin-3-ol Framework: Application to the Total Synthesis of (+)-Deoxoprosopinine
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Facile Transformation of 2-Azetidinones to 2-Piperidones: Application to the Synthesis of the Indolizidine Skeleton and (8 S
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Total synthesis of (−)-ulapualide A, a novel tris-oxazole macrolide from marine nudibranchs, based on some biosynthesis speculation
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