Inovasi Pembelajaran Fikih Haji dan Umroh di Madrasah Aliyah Billingual Pondok Pesantren Junwangi Krian Sidoarjo

Pembelajaran Fikih Haji dan Umroh memang membutuhkan inovasi tersendiri dalam upaya menginternalisasikan nilai-nilai yang ada di dalamnya. Sebab materi Haji dan Umroh setidaknya masih jauh dari bayangan setiap murid di tingkatan Madarasah Aliyah. Karena biasanya Haji dan Umroh dilaksanakan oleh orang orang yang sudah berumur atau dewasa. Inovasi inovasi pembelajaran yang dilakukan inilah yang membuat konsep Haji dan Umroh terasa dekat dalam imajinasi dan mimpi setiap murid. Nilai nilai dari Haji dan Umrohpun ternyata bisa diajarkan menjadi karakter walaupun murid belum berangkat ke tanah suci. Untuk itu, penulis tertarik untuk mengadakan penelitian dengan judul: “Inovasi Pembelajaran Fikih Haji dan Umroh di Madrasah Aliyah Billingual Yayasan Pondok Pesantren Modern Al-Amanah Krian Sidoarjo”. Penelitian ini memfokuskan tujuannya untuk mengetahui Inovasi inovasi pembelajaran Fikih Haji dan Umroh di Madrasah Aliyah Bilingual Al-Amanah, termasuk faktor pendukung dan penghambat gerakan inovasi pembelajaran fikih Haji dan Umroh di MA Bilingual Al-Amanah serta solusinya. Untuk mencapai tujuan tersebut, maka penelitian ini dirancang sebagai penelitian deskriptif kualitatif yang bertujuan untuk menggambarkan keadaan atau fenomena yang sebenarnya dari fakta yang diteliti. Dari penelitian yang telah dilakukan, diperoleh temuan bahwa banyak inovasi yang dilakukan dilingkungan Madrasah Aliyah Billingual terkait dengan pembelajaran Haji dan Umroh. Pertama, dalam aspek tujuan pembelajaran, Madrasah Aliyah Billingual menetapkan tujuan pembelajaran untuk menjadikan murid sebagai pionir, mendekatkan konsep dengan realitanya, memberlakukan integrated curriculum yakni kurikulum yang terpadu, menerapkan pembelajaran kebermaknaan dan pendidikan karakter melalui nilai nilai haji dan umroh. Kedua, dalam aspek struktur pembelajaran, Madrasah Aliyah Billingual menciptakan kelas alam, bekerja sama untuk mensukseskan manasik haji dan umroh serta men-setting pembelajaran haji dan umroh secara baik. Ketiga, dalam aspek metode pembelajaran, Madrasah Aliyah Billingual menambah referensi berupa kitab kuning, menggunakan pembelajaran wetonan dan metode musyawarah dalam pembelajaran haji dan umroh. Keempat, dalam aspek perubahan terhadap aspek aspek pembelajaran menggunakan multimetode pembelajaran dan multimedia. Ada beberapa faktor pendukung sekaligus penghambat dan solusi dalam gerakan inovasi pembelajaran haji dan umroh di Madrasah Aliyah Billingual Pondok Pesantren Al-Amanah Krian Sidoarjo

Prevalence and risk factors of lactic acidosis in children with acute moderate and severe asthma, a prospective observational study.

Lactic acidosis is a common complication of status asthmaticus in adults. However, data is sparse in children. The aim of this study was to describe the prevalence and risk factors for lactic acidosis in children hospitalised for acute moderate or severe asthma. A total of 154 children 2-17 years of age were enrolled in a prospective observational study conducted in a tertiary hospital. All had capillary blood gas assessment 4 h after the first dose of salbutamol in hospital. The primary endpoint was the prevalence of lactic acidosis. Potential contributing factors such as age, sex, BMI, initial degree of asthma severity, type of salbutamol administration (nebuliser or inhaler), steroids, ipratropium bromide, and glucose-containing maintenance fluid represented secondary endpoints. All in all, 87% of patients had hyperlactatemia (lactate concentration > 2.2 mmol/l). Lactic acidosis (lactate concentration > 5 mmol/l and anion gap ≥ 16 mmol/l) was observed in 26%. In multivariate analysis, age more than 6 years (OR = 2.8, 95% CI 1.2-6.6), glycemia above 11 mmol/l (OR = 3.2 95% CI 1.4-7.4), and salbutamol administered by nebuliser (OR = 10, 95% CI 2.7-47) were identified as risk factors for lactic acidosis in children with moderate or severe asthma.Conclusion: Lactic acidosis is a frequent and early complication of acute moderate or severe asthma in children. What is Known: • Lactic acidosis during acute asthma is associated with b2-mimetics administration. • Salbutamol-related lactic acidosis is self-limited but important to recognise, as compensatory hyperventilation of lactic acidosis can be mistaken for respiratory worsening and lead to inappropriate supplemental bronchodilator administration. What is New: • Lactic acidosis is a frequent complication of acute asthma in the paediatric population. • Age older than 6 years, hyperglycaemia, and nebulised salbutamol are risk factors for lactic acidosis during asthma

The late Vistulian and Holocene evolution of Jezioro Lake : a record of environmental change in southern Poland found in deposits and landforms

Jezioro Lake is the only natural lake in southern Poland outside mountainous areas to have existed continuously since the Pleistocene. The record of environmental change in the Late Vistulian (Weichselian) and Holocene is preserved in the deposits and landforms around the lake. This paper presents the results of paleogeographical and paleoecological research that emabled us to reconstruct the history of the Jezioro Lake. At the end of the Vistulian period, the outlet of the lake was blocked by a parabolic dune moving in from the west. Limnic sedimentation was evident in the sediment core at all levels from the Holocene, with remains of Cladocera, Chironomidae larvae, and aquatic plants. The lake did not disappear at that time, although its area decreased by a factor of 12 by the end of the period. Paleobotanical research permitted the reconstruction of sequences of plant communities and changes in nutrient status and water level. An initial oligotrophic lake, as indicated by the presence of Isoe¨tes lacustris L., changed to a eutrophic lake, as indicated by the presence of Potamogeton natans L. and Nuphar sp., then the lake progressed to the present-day dystrophic lake that is surrounded by a swamp. The profile of organic deposits contains a record of environmental change at least since the Younger Dryas in southern Poland

Bis[bis­(3,5-dimethyl-1H-pyrazol-1-yl)­borato]cobalt(II)

The asymmetric unit of the title compound, [Co(C10H16BN4)2], comprises one unit of the complex. The geometry around the CoII ion is a distorted tetra­hedron. The dihedral angles between the pyrazole rings in the two ligands are 47.19 (15) and 47.20 (16)°, while that between the coordination planes is 79.77 (7)°

Wireless Electrical-Molecular Quantum Signalling for Cancer Cell Induced Death

Quantum biological electron tunnelling (QBET) underpins cellular behaviour. Control ofelectrical-molecular communication could revolutionise the development of disruptivetechnologies for understanding and modulating molecular signalling. Current communicationtechnology is not appropriate for interfacing with cells at a spatial/temporal level equivalent tothe native biological signalling. We merge bipolar nano-electrochemical tools with cancercells. Gold-bipolar nanoelectrodes functionalised with electron acceptor-donor-species, weredeveloped as electric field bio-actuators we term bio-nanoantennae. Remote electrical inputregulated electron transport between the acceptor-donor species at the bio-nanoantennae in aselective manner. The wireless modulation of electron transport results in QBET triggeringapoptosis in patient-derived cancer cells representing electrical-molecular communication.Transcriptomics data highlight the electric field targets the cancer cells in a unique manner.The stated insight and invention open a plethora of applications in healthcare. This may leadto new quantum-based medical diagnostics and treatments, as well as understanding of thebiological physics.</p

Wireless electrical–molecular quantum signalling for cancer cell apoptosis

Quantum biological tunnelling for electron transfer is involved incontrolling essential functions for life such as cellular respiration andhomoeostasis. Understanding and controlling the quantum effects inbiology has the potential to modulate biological functions. Here we mergewireless nano-electrochemical tools with cancer cells for control overelectron transfer to trigger cancer cell death. Gold bipolar nanoelectrodesfunctionalized with redox-active cytochrome c and a redox mediatorzinc porphyrin are developed as electric-field-stimulating bio-actuators,termed bio-nanoantennae. We show that a remote electrical input regulateselectron transport between these redox molecules, which results inquantum biological tunnelling for electron transfer to trigger apoptosisin patient-derived cancer cells in a selective manner. Transcriptomicsdata show that the electric-field-induced bio-nanoantenna targets thecancer cells in a unique manner, representing electrically induced controlof molecular signalling. The work shows the potential of quantum-basedmedical diagnostics and treatments.</p

Untargeted Metabolomic Characterization of Glioblastoma Intra-Tumor Heterogeneity Using OrbiSIMS

Glioblastoma (GBM) is an incurable brain cancer with a median survival of less than two years from diagnosis. The standard treatment of GBM is multimodality therapy comprising surgical resection, radiation, and chemotherapy. However, prognosis remains poor, and there is an urgent need for effective anticancer drugs. Since different regions of a single GBM contain multiple cancer subpopulations ("intra-tumor heterogeneity"), this likely accounts for therapy failure as certain cancer cells can escape from immune surveillance and therapeutic threats. Here, we present metabolomic data generated using the Orbitrap secondary ion mass spectrometry (OrbiSIMS) technique to investigate brain tumor metabolism within its highly heterogeneous tumor microenvironment. Our results demonstrate that an OrbiSIMS-based untargeted metabolomics method was able to discriminate morphologically distinct regions (viable, necrotic, and non-cancerous) within single tumors from formalin-fixed paraffin-embedded tissue archives. Specifically, cancer cells from necrotic regions were separated from viable GBM cells based on a set of metabolites including cytosine, phosphate, purine, xanthine, and 8-hydroxy-7-methylguanine. Moreover, we mapped ubiquitous metabolites across necrotic and viable regions into metabolic pathways, which allowed for the discovery of tryptophan metabolism that was likely essential for GBM cellular survival. In summary, this study first demonstrated the capability of OrbiSIMS for in situ investigation of GBM intra-tumor heterogeneity, and the acquired information can potentially help improve our understanding of cancer metabolism and develop new therapies that can effectively target multiple subpopulations within a tumor

Modulating the biological function of protein by tailoring the adsorption orientation on nanoparticles

Protein orientation in nanoparticle-protein conjugates plays a crucial role in binding to cell receptors and ultimately, defines their targeting efficiency. Therefore, understanding fundamental aspects of the role of protein orientation upon adsorption on the surface of nanoparticles (NPs) is vital for the development of clinically important protein-based nanomedicines. In this work, new insights on the effect of the different orientation of cytochrome c (cyt c) bound to gold nanoparticles (GNPs) using various ligands on its apoptotic activity is reported. Time-of-Flight Secondary-Ion Mass Spectrometry (ToF-SIMS), electrochemical and circular dichroism (CD) analyses are used to investigate the characteristics of cyt c orientation and structure on functionalized GNPs. These studies indicate that the orientation and position of the heme ring inside the cyt c structure can be altered by changing the surface chemistry on the GNPs. A difference in the apoptosis inducing capability because of different orientation of cyt c bound to the GNPs is observed. These findings indicate that the biological activity of a protein can be modulated on the surface of NPs by varying its adsorption orientation. This study will impact on the rational design of new nanoscale biosensors, bioelectronics, and nanoparticle-protein based drugs

Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste

Purpose: High-grade glioma (HGG) treatment is limited by the inability of otherwise potentially efficacious drugs to penetrate the blood brain barrier. We evaluate the unique intra-cavity delivery mode and translational potential of a blend of poly(DL-lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) paste combining temozolomide and etoposide to treat surgically resected HGG. Experimental Design: To prolong stability of temozolomide pro-drug, combined in vitro drug release was quantitatively assessed from low pH-based PLGA/PEG using advanced analytical methods. In vitro cytotoxicity was measured against a panel of HGG cell lines and patient-derived cultures using metabolic assays. In vivo safety and efficacy was evaluated using orthotopic 9L gliosarcoma allografts, previously utilized pre-clinically to develop Gliadel®. Results: Combined etoposide and temozolomide in vitro release (22 and 7 days respectively) was achieved from a lactic acid-based PLGA/PEG paste, used to enhance stability of temozolomide prodrug. HGG cells from central-enhanced regions were more sensitive to each compound relative to primary lines derived from the HGG invasive margin. Both drugs retained cytotoxic capability upon release from PLGA/PEG. In vivo studies revealed a significant overall survival benefit in post-surgery 9L orthotopic gliosarcomas treated with intra-cavity delivered PLGA/PEG/temozolomide/etoposide and enhanced with adjuvant radiotherapy. Long-term survivorship was observed in over half the animals with histological confirmation of disease-free brain. Conclusions: The significant survival benefit of intra-cavity chemotherapy demonstrates clinical applicability of PLGA/PEG paste-mediated delivery of temozolomide and etoposide adjuvant to radiotherapy. PLGA/PEG paste offers a future platform for combination delivery of molecular targeted compounds