A study of the adhesion and cohesion of metals Third quarterly progress report, 9 Sep. - 9 Dec. 1965

Adhesion and cohesion of metal

Report to the Wisconsin Legislature on the Learnfare Evaluation (1991)

In July, 1987 the State of Wisconsin enacted legislation implementing a Learnfare policy for families with teenagers receiving Aid to Families with Dependent Children (AFDC) and who have not completed high school or obtained a GED. Under the policy families are denied AFDC support for teens (or teen parents) not attending school regularly. The Employment and Training Institute was selected by the state Department of Health and Social Services to conduct an evaluation of the program. This report was made to the state Legislature on the progress of the evaluatio

Matter effects in the D0-D0bar system

We discuss the impact of matter effects in the D0-D0bar system. We show that such effects could, in principle, be measured, but that they cannot be used to probe the mass difference x_D or the lifetime difference y_D. This occurs because the mixing effects and the matter effects decouple at short times. We also comment briefly on the B systems.Comment: 6 pages, RevTe

A study of the adhesion and cohesion of metals Interim summary report, 9 Mar. 1965 - 9 Mar. 1966

Metal alloy adhesion in high vacuu

Optimal entanglement witnesses for continuous-variable systems

This paper is concerned with all tests for continuous-variable entanglement that arise from linear combinations of second moments or variances of canonical coordinates, as they are commonly used in experiments to detect entanglement. All such tests for bi-partite and multi-partite entanglement correspond to hyperplanes in the set of second moments. It is shown that all optimal tests, those that are most robust against imperfections with respect to some figure of merit for a given state, can be constructed from solutions to semi-definite optimization problems. Moreover, we show that for each such test, referred to as entanglement witness based on second moments, there is a one-to-one correspondence between the witness and a stronger product criterion, which amounts to a non-linear witness, based on the same measurements. This generalizes the known product criteria. The presented tests are all applicable also to non-Gaussian states. To provide a service to the community, we present the documentation of two numerical routines, FULLYWIT and MULTIWIT, which have been made publicly available.Comment: 14 pages LaTeX, 1 figure, presentation improved, references update

Pairing of Competitive and Topologically Distinct Regulatory Modules Enhances Patterned Gene Expression

Biological networks are inherently modular, yet little is known about how modules are assembled to enable coordinated and complex functions. We used RNAi and time series, whole-genome microarray analyses to systematically perturb and characterize components of a Caenorhabditis elegans lineage-specific transcriptional regulatory network. These data are supported by selected reporter gene analyses and comprehensive yeast one-hybrid and promoter sequence analyses. Based on these results, we define and characterize two modules composed of muscle- and epidermal-specifying transcription factors that function together within a single cell lineage to robustly specify multiple cell types. The expression of these two modules, although positively regulated by a common factor, is reliably segregated among daughter cells. Our analyses indicate that these modules repress each other, and we propose that this cross-inhibition coupled with their relative time of induction function to enhance the initial asymmetry in their expression patterns, thus leading to the observed invariant gene expression patterns and cell lineage. The coupling of asynchronous and topologically distinct modules may be a general principle of module assembly that functions to potentiate genetic switches.Molecular and Cellular Biolog

The role of pathology in an investigation of an outbreak of West Nile encephalitis in New York, 1999.

An outbreak of encephalitis occurred in New York City in late August 1999, the first caused by West Nile virus in North America. Histopathologic and immunopathologic examinations performed on human autopsy materials helped guide subsequent laboratory and epidemiologic investigations that led to identification of the etiologic agent

The First Human Epitope Map of the Alphaviral E1 and E2 Proteins Reveals a New E2 Epitope with Significant Virus Neutralizing Activity

Although the murine immune response to Venezuelan equine encephalitis virus (VEEV) is well-characterized, little is known about the human antibody response to VEEV. In this study we used phage display technology to isolate a panel of 11 VEEV-specfic Fabs from two human donors. Seven E2-specific and four E1-specific Fabs were identified and mapped to five E2 epitopes and three E1 epitopes. Two neutralizing Fabs were isolated, E2-specific F5 and E1-specific L1A7, although the neutralizing capacity of L1A7 was 300-fold lower than F5. F5 Fab was expressed as a complete IgG1 molecule, F5 native (n) IgG. Neutralization-escape VEEV variants for F5 nIgG were isolated and their structural genes were sequenced to determine the theoretical binding site of F5. Based on this sequence analysis as well as the ability of F5 to neutralize four neutralization-escape variants of anti-VEEV murine monoclonal antibodies (mapped to E2 amino acids 182–207), a unique neutralization domain on E2 was identified and mapped to E2 amino acids 115–119