Anaesthesia for trauma patients

No Abstract

Constant probe orientation for fast contact-based inspection of 3D free-form surfaces using (3+2)-axis inspection machines

A new probe optimization method for contact based (3+2)-axis inspection machines is proposed. Given an inspection path of a stylus on a free-form surface, an optimal orientation of the stylus is computed such that (i) the inclination angle of the stylus is within a given angular range with respect to the surface normal, (ii) the motion of the stylus is globally collision free, and (iii) the stylus remains constant in the coordinate system of the measuring machine. The last condition guarantees that the inspection motion requires only the involvement of the three translational axes of the measuring machine. The numerical simulations were validated through physical experiments on a testcase of a tooth of a bevel gear due to the surface complexity and probe accessibility. This optimized method was compared to 3-axis and 5-axis inspection strategies, showing that the fixed (3+2)-axis stylus returns more accurate inspection results compared to the traditional 3-axis approach and similar to 5-axis approach

Constant probe orientation for fast contact-based inspection of 3D free-form surfaces using (3+2)-axis inspection machines

A new probe optimization method for contact based (3+2)-axis inspection machines is proposed. Given an inspection path of a stylus on a free-form surface, an optimal orientation of the stylus is computed such that (i) the inclination angle of the stylus is within a given angular range with respect to the surface normal, (ii) the motion of the stylus is globally collision free, and (iii) the stylus remains constant in the coordinate system of the measuring machine. The last condition guarantees that the inspection motion requires only the involvement of the three translational axes of the measuring machine. The numerical simulations were validated through physical experiments on a testcase of a tooth of a bevel gear due to the surface complexity and probe accessibility. This optimized method was compared to 3-axis and 5-axis inspection strategies, showing that the fixed (3+2)-axis stylus returns more accurate inspection results compared to the traditional 3-axis approach and similar to 5-axis approach.RYC-2017-2264

ASIC para sistemas de medidas ambientales

El circuito integrado que aquí se describe ha sido diseñado con tecnología puramente digital, y tiene como función servir como centro concentrador de datos en estaciones meteorológicas, aunque por su diseño genérico puede ser usado en cualquier otro campo. Su objetivo principal es la adquisición de medidas (condiciones ambientales como velocidad y dirección del viento, tempera-turas, humedades relativas,...) y la generación de señales analógicas y digitales telemandadas procedentes de un canal de radio o de un canal SPI. Esta realización se enmarca dentro del programa GAME y ha sido desarrollada en colaboración con la empresa SAINCO

Extraction of emerging contaminants from environmental waters and urine by dispersive liquid-liquid microextraction with solidification of the floating organic droplet using fenchol:acetic acid deep eutectic mixtures

In this work, several eutectic mixtures formed by fenchol and acetic acid at seven molar ratios (between 4:1 and 1:4) were characterized and studied for the first time for their possible application as extraction solvents in dispersive liquid-liquid microextraction based on the solidification of the floating organic droplet (DLLME-SFO). A group of 13 emerging contaminants (gemfibrozil, bisphenol F, bisphenol A, 17β-estradiol, testosterone, estrone, levonorgestrel, 4-tert-octylphenol, butyl benzyl phthalate, dibutyl phthalate, 4-octylphenol, 4-nonylphenol, and dihexyl phthalate) was selected and determined by liquid chromatography with ultraviolet and tandem mass spectrometry detection. Among the studied mixtures, only those of 2:1 and 1:1 provided the suitable features from an operational and repeatability point of view, suggesting that several eutectic mixtures of the same components may also provide similar results. Once the extraction conditions of both mixtures were optimized, the method was applied to the extraction of sea water, urine, and wastewater at different concentration levels, allowing the achievement of absolute recovery values between 49 and 100% for most analytes with relative standard deviation values below 19%. In addition, several samples of each type were analyzed, finding bisphenol A and gemfibrozil in some of them. The greenness of the method was also evaluated using the AGREEprep metric. The DLLME-SFO procedure was found to be very simple, quick, and effective and with a good sample throughput

Acacia, cherry and oak wood chips used for a short aging period of rosé wines: effects on general phenolic parameters, volatile composition and sensory profile

Research ArticleBACKGROUND: There is a restricted knowledge about the potential impact of the use of different wood chip species on the rosé wine aging process. Thus, the aim of this work was to evaluate the general phenolic parameters, aroma composition and sensory profile of rosé wines during a shortmaturation (20 aging days) in contact with wood chips fromoak, acacia and cherry. In addition, the different wood chips were added to a rosé wine without a previous clarification process (unfined wine) and to a rosé wine submitted to a clarification process (fined wine). RESULTS: For thebriefmaturation time considered, theuseofdifferentwoodchips induceda tendency foranincreaseof phenolic content, in particular for unfined rosé wine aged in contact with acacia chips. For volatile composition, the differentiation was clearer for aldehyde compounds group. Regarding sensorial overall appreciation the panel test preferred the unfined roséwine aged in contact with acacia wood chips. CONCLUSIONS: The results show that, in general, the use of different wood chip species (acacia, cherry and oak) for a brief maturation time of rosé wines could play an important role in rosé wine characteristics, in particular in their phenolic compositioninfo:eu-repo/semantics/publishedVersio

Inflammatory biomarkers and brain health indicators in children with overweight and obesity: The ActiveBrains project

INTRODUCTION: Chronic inflammation plays an important role on the pathogenesis of several cardiovascular and metabolic diseases, as well as on brain function and behaviour. The aim of the present study was to examine the associations between inflammatory biomarkers and a wide range of brain health indicators (i.e., academic performance, executive function, behavioural and emotional functioning, and brain volume) in children with overweight/obesity. METHODS: A total of 107 children (10.0 ± 1.1 years, 41% girls) from the ActiveBrains project were included in the analysis. Five inflammatory biomarkers were analysed in plasma: white blood cell (WBC) count, interleukin-6 (IL-6), interleukin-1beta, tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP). Academic performance was assessed by Woodcock-Munoz Tests of Achievement. Executive function was assessed through the Design Fluency Test for cognitive flexibility, the Stroop test for cognitive inhibition, and the Delayed Non-Match-to-Sample task for working memory. Behavioural and emotional functioning was evaluated through the Behavior Assessment System for Children (BASC) questionnaire. Total and regional brain volume was assessed by magnetic resonance imaging. RESULTS: IL-6 was inversely associated with adaptive skills (beta = -0.228; p = 0.030), while TNF-alpha was related to mathematics (beta = -0.198; p = 0.034). In addition, CRP was positively associated with externalizing (beta = 0.246; p = 0.046) and internalizing problems (beta = 0.234; p = 0.039), as well as the behavioural symptoms index (beta = 0.236; p = 0.047). However, these significant associations disappeared after multiple comparisons correction. Inflammatory biomarkers were not associated with executive function and total brain volumes. Regarding regional brain analyses, WBC was positively associated with gray matter volume in the left middle temporal gyrus (beta = 0.387; p < 0.001, k = 44), and CRP was positively associated with gray matter volume in the right superior temporal gyrus (beta = 0.439; p < 0.001, k = 29). Additionally, when adjusting by total brain volume, CRP was positively associated with gray matter volume in the right supplementary motor cortex (beta = 0.453; p < 0.001, k = 51). Moreover, both, IL-6 (beta = 0.366; p < 0.001, k = 81) and TNF-alpha (beta = 0.368; p < 0.001, k = 62) were positively associated with white matter volume around the right inferior frontal gyrus pars opercularis, while CRP was inversely associated with white matter volume around the left superior frontal gyrus (beta = -0.482; p < 0.001, k = 82). After adjusting by total brain volume, CRP was also inversely associated with white matter volume in 3 additional clusters (beta ranging from -0.473 to -0.404; p < 0.001, k = 87). CONCLUSIONS: Inflammation was slightly associated with brain health (i.e., academic performance, behavioural and emotional functioning and regional brain volume) in children with overweight or obesity. Further larger longitudinal and interventional studies are warranted to elucidate the short-term and long-term effect of systemic low-grade inflammation on children's brain health

Engineering Iron Oxide Nanoparticles for Clinical Settings

Iron oxide nanoparticles (IONPs) occupy a privileged position among magnetic nanomaterials with potential applications in medicine and biology. They have been widely used in preclinical experiments for imaging contrast enhancement, magnetic resonance, immunoassays, cell tracking, tissue repair, magnetic hyperthermia and drug delivery. Despite these promising results, their successful translation into a clinical setting is strongly dependent upon their physicochemical properties, toxicity and functionalization possibilities. Currently, IONPs-based medical applications are limited to the use of non-functionalized IONPs smaller than 100 nm, with overall narrow particle size distribution, so that the particles have uniform physical and chemical properties. However, the main entry of IONPs into the scene of medical application will surely arise from their functionalization possibilities that will provide them with the capacity to target specific cells within the body, and hence to play a role in the development of specific therapies. In this review, we offer an overview of their basic physicochemical design parameters, giving an account of the progress made in their functionalization and current clinical applications. We place special emphasis on past and present clinical trials

Adaptation and Testing of the Factorial Structure of the Physical Education Grit Scale for Use in Secondary Education in Spain

The challenges faced by students during Physical Education classes embrace both physical and academic aspects. Therefore, each individual possesses a series of internal psychological mechanisms, such as Grit, which allow them to adapt and overcome the vicissitudes. However, there are no scales that assess Grit in Span. Thus, the aim of the present study is to test the factor structure of the Physical Education Grit Scale in Span of Physical Education classes. For this purpose, 857 secondary school students took part in the present study. In order to test the factor structure, a confirmatory factor analysis, an exploratory factor analysis, an analysis of the reliability of the questionnaire and an analysis of temporal stability were carried out. The results showed that the factor structure consisted of two factors and four sub-factors (¿2/df = 2.17 (p = 0.001); CFI = 0.96; TLI = 0.96; IFI = 0.96; RMSEA = 0.051; SRMR = 0.037). In addition, the reliability and temporal stability analyses showed acceptable indices. Based on these results, evidence of reliability and validity of the Physical Education Grit Scale in Span of Physical Education is provided