How can exploratory learning with games and simulations within the curriculum be most effectively evaluated?

There have been few attempts to introduce frameworks that can help support tutors evaluate educational games and simulations that can be most effective in their particular learning context and subject area. The lack of a dedicated framework has produced a significant impediment for uptake of games and simulations particularly in formal learning contexts. This paper aims to address this shortcoming by introducing a four-dimensional framework for helping tutors to evaluate the potential of using games- and simulation- based learning in their practice, and to support more critical approaches to this form of games and simulations. The four-dimensional framework is applied to two examples from practice to test its efficacy and structure critical reflection upon practice

Introduction to Focus Issue : Dynamics in Systems Biology

Peer reviewedPublisher PD

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.

Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important pharmacological target in the treatment of cancer due to its cellular role as a 'DNA-strand break sensor', which leads in part to resistance to some existing chemo- and radiological treatments. Inhibitors have now been developed which prevent PARP-1 from synthesizing poly(ADP-ribose) in response to DNA-breaks and potentiate the cytotoxicity of DNA damaging agents. However, with the recent discoveries of PARP-2, which has a similar DNA-damage dependent catalytic activity, and additional members containing the 'PARP catalytic' signature, the isoform selectivity and resultant pharmacological effects of existing inhibitors are brought into question. We present here the crystal structure of the catalytic fragment of murine PARP-2, at 2.8 A resolution, and compare this to the catalytic fragment of PARP-1, with an emphasis on providing a possible framework for rational drug design in order to develop future isoform-specific inhibitors

The Brans-Dicke-Rastall theory

We formulate a theory combining the principles of a scalar-tensor gravity and Rastall's proposal of a violation of the usual conservation laws. We obtain a scalar-tensor theory with two parameters $\omega$ and $\lambda$, the latter quantifying the violation of the usual conservation laws. The only exact spherically symmetric solution is that of Robinson-Bertotti besides Schwarzschild solution. A PPN analysis reveals that General Relativity results are reproduced when $\lambda = 0$. The cosmological case displays a possibility of deceleration/acceleration or acceleration/deceleration transitions during the matter dominated phase depending on the values of the free parameters.Comment: 17 pages, 3 figure

The Current Ability to Test Theories of Gravity with Black Hole Shadows

Our Galactic Center, Sagittarius A* (Sgr A*), is believed to harbour a supermassive black hole (BH), as suggested by observations tracking individual orbiting stars. Upcoming sub-millimetre very-long-baseline-interferometry (VLBI) images of Sgr A* carried out by the Event-Horizon-Telescope Collaboration (EHTC) are expected to provide critical evidence for the existence of this supermassive BH. We assess our present ability to use EHTC images to determine if they correspond to a Kerr BH as predicted by Einstein's theory of general relativity (GR) or to a BH in alternative theories of gravity. To this end, we perform general-relativistic magnetohydrodynamical (GRMHD) simulations and use general-relativistic radiative transfer (GRRT) calculations to generate synthetic shadow images of a magnetised accretion flow onto a Kerr BH. In addition, and for the first time, we perform GRMHD simulations and GRRT calculations for a dilaton BH, which we take as a representative solution of an alternative theory of gravity. Adopting the VLBI configuration from the 2017 EHTC campaign, we find that it could be extremely difficult to distinguish between BHs from different theories of gravity, thus highlighting that great caution is needed when interpreting BH images as tests of GR.Comment: Published in Nature Astronomy on 16.04.18 (including supplementary information); simulations at https://blackholecam.org/telling_bhs_apart